Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| astrocyte | 15 studies | 50% ± 21% | |
| fibroblast | 9 studies | 27% ± 8% | |
| basal cell | 4 studies | 31% ± 18% | |
| endothelial cell | 3 studies | 46% ± 22% | |
| glial cell | 3 studies | 30% ± 7% | |
| progenitor cell | 3 studies | 47% ± 9% | |
| connective tissue cell | 3 studies | 27% ± 9% | |
| pericyte | 3 studies | 24% ± 7% | |
| type II pneumocyte | 3 studies | 21% ± 5% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| adipose | 3 studies | 24% ± 3% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| breast | 100% | 3133.64 | 459 / 459 | 96% | 20.24 | 1075 / 1118 |
| skin | 100% | 3205.85 | 1809 / 1809 | 96% | 16.14 | 453 / 472 |
| ovary | 100% | 3460.66 | 180 / 180 | 81% | 6.58 | 347 / 430 |
| uterus | 100% | 4558.59 | 170 / 170 | 79% | 7.79 | 362 / 459 |
| thymus | 100% | 2058.54 | 651 / 653 | 77% | 4.83 | 464 / 605 |
| prostate | 100% | 2032.72 | 245 / 245 | 74% | 3.31 | 369 / 502 |
| lung | 99% | 1294.29 | 574 / 578 | 66% | 5.24 | 762 / 1155 |
| esophagus | 100% | 1786.32 | 1439 / 1445 | 66% | 8.37 | 120 / 183 |
| bladder | 100% | 1951.05 | 21 / 21 | 54% | 3.42 | 274 / 504 |
| brain | 61% | 555.24 | 1601 / 2642 | 81% | 5.03 | 569 / 705 |
| intestine | 94% | 3025.29 | 910 / 966 | 21% | 0.94 | 113 / 527 |
| adrenal gland | 93% | 710.00 | 240 / 258 | 21% | 0.93 | 49 / 230 |
| adipose | 100% | 2492.18 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| stomach | 65% | 845.19 | 235 / 359 | 34% | 1.62 | 97 / 286 |
| blood vessel | 99% | 1160.85 | 1325 / 1335 | 0% | 0 | 0 / 0 |
| kidney | 53% | 298.54 | 47 / 89 | 45% | 1.91 | 403 / 901 |
| tonsil | 0% | 0 | 0 / 0 | 91% | 7.63 | 41 / 45 |
| pancreas | 7% | 33.66 | 23 / 328 | 69% | 3.60 | 122 / 178 |
| eye | 0% | 0 | 0 / 0 | 73% | 3.11 | 58 / 80 |
| heart | 45% | 240.22 | 390 / 861 | 0% | 0 | 0 / 0 |
| spleen | 29% | 140.59 | 71 / 241 | 0% | 0 | 0 / 0 |
| muscle | 21% | 118.02 | 171 / 803 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 3% | 0.14 | 1 / 29 |
| liver | 0% | 0 | 0 / 226 | 2% | 0.15 | 9 / 406 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| peripheral blood | 0% | 0 | 0 / 929 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0002052 | Biological process | positive regulation of neuroblast proliferation |
| GO_0001658 | Biological process | branching involved in ureteric bud morphogenesis |
| GO_0030324 | Biological process | lung development |
| GO_0060831 | Biological process | smoothened signaling pathway involved in dorsal/ventral neural tube patterning |
| GO_0060873 | Biological process | anterior semicircular canal development |
| GO_0048593 | Biological process | camera-type eye morphogenesis |
| GO_0060366 | Biological process | lambdoid suture morphogenesis |
| GO_0001656 | Biological process | metanephros development |
| GO_0048566 | Biological process | embryonic digestive tract development |
| GO_0002062 | Biological process | chondrocyte differentiation |
| GO_0042733 | Biological process | embryonic digit morphogenesis |
| GO_0021798 | Biological process | forebrain dorsal/ventral pattern formation |
| GO_0021819 | Biological process | layer formation in cerebral cortex |
| GO_0021775 | Biological process | smoothened signaling pathway involved in ventral spinal cord interneuron specification |
| GO_0090090 | Biological process | negative regulation of canonical Wnt signaling pathway |
| GO_2000647 | Biological process | negative regulation of stem cell proliferation |
| GO_0021631 | Biological process | optic nerve morphogenesis |
| GO_0032331 | Biological process | negative regulation of chondrocyte differentiation |
| GO_0060021 | Biological process | roof of mouth development |
| GO_0043066 | Biological process | negative regulation of apoptotic process |
| GO_0060875 | Biological process | lateral semicircular canal development |
| GO_1903010 | Biological process | regulation of bone development |
| GO_0048589 | Biological process | developmental growth |
| GO_0042475 | Biological process | odontogenesis of dentin-containing tooth |
| GO_0072089 | Biological process | stem cell proliferation |
| GO_0021776 | Biological process | smoothened signaling pathway involved in spinal cord motor neuron cell fate specification |
| GO_0046639 | Biological process | negative regulation of alpha-beta T cell differentiation |
| GO_0007224 | Biological process | smoothened signaling pathway |
| GO_0009954 | Biological process | proximal/distal pattern formation |
| GO_0001701 | Biological process | in utero embryonic development |
| GO_0043585 | Biological process | nose morphogenesis |
| GO_0006357 | Biological process | regulation of transcription by RNA polymerase II |
| GO_0001649 | Biological process | osteoblast differentiation |
| GO_0042307 | Biological process | positive regulation of protein import into nucleus |
| GO_0045879 | Biological process | negative regulation of smoothened signaling pathway |
| GO_0060367 | Biological process | sagittal suture morphogenesis |
| GO_0045669 | Biological process | positive regulation of osteoblast differentiation |
| GO_0070242 | Biological process | thymocyte apoptotic process |
| GO_0120223 | Biological process | larynx morphogenesis |
| GO_0033077 | Biological process | T cell differentiation in thymus |
| GO_0060364 | Biological process | frontal suture morphogenesis |
| GO_0006606 | Biological process | protein import into nucleus |
| GO_0006355 | Biological process | regulation of DNA-templated transcription |
| GO_0035108 | Biological process | limb morphogenesis |
| GO_0007442 | Biological process | hindgut morphogenesis |
| GO_0045060 | Biological process | negative thymic T cell selection |
| GO_0046632 | Biological process | alpha-beta T cell differentiation |
| GO_0046638 | Biological process | positive regulation of alpha-beta T cell differentiation |
| GO_0060594 | Biological process | mammary gland specification |
| GO_0007405 | Biological process | neuroblast proliferation |
| GO_0021766 | Biological process | hippocampus development |
| GO_0032332 | Biological process | positive regulation of chondrocyte differentiation |
| GO_0016485 | Biological process | protein processing |
| GO_0043586 | Biological process | tongue development |
| GO_0021861 | Biological process | forebrain radial glial cell differentiation |
| GO_0061005 | Biological process | cell differentiation involved in kidney development |
| GO_0045893 | Biological process | positive regulation of DNA-templated transcription |
| GO_0009952 | Biological process | anterior/posterior pattern specification |
| GO_0060840 | Biological process | artery development |
| GO_0045892 | Biological process | negative regulation of DNA-templated transcription |
| GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
| GO_0007507 | Biological process | heart development |
| GO_0000122 | Biological process | negative regulation of transcription by RNA polymerase II |
| GO_0071625 | Biological process | vocalization behavior |
| GO_0022018 | Biological process | lateral ganglionic eminence cell proliferation |
| GO_0045665 | Biological process | negative regulation of neuron differentiation |
| GO_0030318 | Biological process | melanocyte differentiation |
| GO_0048557 | Biological process | embryonic digestive tract morphogenesis |
| GO_0048709 | Biological process | oligodendrocyte differentiation |
| GO_0048702 | Biological process | embryonic neurocranium morphogenesis |
| GO_0007411 | Biological process | axon guidance |
| GO_0005634 | Cellular component | nucleus |
| GO_0005730 | Cellular component | nucleolus |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0017053 | Cellular component | transcription repressor complex |
| GO_0005930 | Cellular component | axoneme |
| GO_0043231 | Cellular component | intracellular membrane-bounded organelle |
| GO_0005929 | Cellular component | cilium |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0097546 | Cellular component | ciliary base |
| GO_0016607 | Cellular component | nuclear speck |
| GO_0097542 | Cellular component | ciliary tip |
| GO_1990788 | Cellular component | GLI-SUFU complex |
| GO_0005829 | Cellular component | cytosol |
| GO_0000978 | Molecular function | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| GO_0003682 | Molecular function | chromatin binding |
| GO_0035035 | Molecular function | histone acetyltransferase binding |
| GO_0046872 | Molecular function | metal ion binding |
| GO_0036033 | Molecular function | mediator complex binding |
| GO_0042826 | Molecular function | histone deacetylase binding |
| GO_0003700 | Molecular function | DNA-binding transcription factor activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0000977 | Molecular function | RNA polymerase II transcription regulatory region sequence-specific DNA binding |
| GO_0000981 | Molecular function | DNA-binding transcription factor activity, RNA polymerase II-specific |
| GO_1990837 | Molecular function | sequence-specific double-stranded DNA binding |
| GO_0008013 | Molecular function | beta-catenin binding |
| Gene name | GLI3 |
| Protein name | Transcriptional activator GLI3 (GLI3 form of 190 kDa) (GLI3-190) (GLI3 full-length protein) (GLI3FL) [Cleaved into: Transcriptional repressor GLI3R (GLI3 C-terminally truncated form) (GLI3 form of 83 kDa) (GLI3-83)] GLI family zinc finger 3 |
| Synonyms | |
| Description | FUNCTION: Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in regulating the size of the zone of distal chondrocytes, in restricting the zone of PTHLH expression in distal cells and in activating chondrocyte proliferation. Binds to the minimal GLI-consensus sequence 5'-GGGTGGTC-3'. . |
| Accessions | A0A2R8YGX0 F8WEV4 ENST00000395925.8 ENST00000642432.1 ENST00000479210.1 ENST00000437480.1 A0A2R8Y6R3 A0A2R8Y723 ENST00000677288.1 ENST00000678978.1 A0A7I2V4V2 A0A7I2V4X9 P10071 ENST00000677605.1 ENST00000643264.1 ENST00000647255.1 ENST00000428534.2 ENST00000678429.1 A0A7I2V3B8 |
