SOST | OmnibusX

Name	Number of supported studies	Average coverage
glomerular endothelial cell	4 studies	79% ± 7%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of SOST at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
blood vessel	92%	3692.64	1222 / 1335	0%	0	0 / 0
kidney	85%	1071.84	76 / 89	4%	0.13	32 / 901
lung	18%	28.62	102 / 578	26%	18.31	298 / 1155
heart	26%	40.47	223 / 861	0%	0	0 / 0
esophagus	1%	1.30	14 / 1445	25%	16.74	45 / 183
tonsil	0%	0	0 / 0	24%	2.21	11 / 45
ovary	2%	0.68	3 / 180	22%	1.26	94 / 430
uterus	1%	0.55	1 / 170	13%	2.48	59 / 459
skin	6%	7.34	114 / 1809	3%	0.08	12 / 472
thymus	7%	20.48	43 / 653	2%	0.20	12 / 605
bladder	0%	0	0 / 21	8%	9.43	41 / 504
lymph node	0%	0	0 / 0	7%	0.28	2 / 29
brain	3%	1.67	69 / 2642	3%	0.06	19 / 705
breast	2%	2.01	10 / 459	3%	0.11	31 / 1118
spleen	5%	3.00	11 / 241	0%	0	0 / 0
adipose	4%	6.49	52 / 1204	0%	0	0 / 0
pancreas	2%	1.16	5 / 328	1%	0.07	2 / 178
prostate	2%	0.86	4 / 245	1%	0.03	4 / 502
stomach	1%	0.23	2 / 359	2%	0.05	5 / 286
intestine	1%	0.52	7 / 966	2%	0.04	8 / 527
adrenal gland	0%	0	0 / 258	1%	0.02	3 / 230
liver	0%	0	0 / 226	1%	0.17	4 / 406
muscle	0%	0.17	2 / 803	0%	0	0 / 0
peripheral blood	0%	0.05	1 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0030279	Biological process	negative regulation of ossification
GO_0031333	Biological process	negative regulation of protein-containing complex assembly
GO_0071374	Biological process	cellular response to parathyroid hormone stimulus
GO_0030514	Biological process	negative regulation of BMP signaling pathway
GO_0090090	Biological process	negative regulation of canonical Wnt signaling pathway
GO_0060070	Biological process	canonical Wnt signaling pathway
GO_0030509	Biological process	BMP signaling pathway
GO_0030178	Biological process	negative regulation of Wnt signaling pathway
GO_0045893	Biological process	positive regulation of DNA-templated transcription
GO_0009612	Biological process	response to mechanical stimulus
GO_0001503	Biological process	ossification
GO_0005615	Cellular component	extracellular space
GO_0005576	Cellular component	extracellular region
GO_0032991	Cellular component	protein-containing complex
GO_0005794	Cellular component	Golgi apparatus
GO_0062023	Cellular component	collagen-containing extracellular matrix
GO_0008201	Molecular function	heparin binding
GO_0140297	Molecular function	DNA-binding transcription factor binding
GO_0030246	Molecular function	carbohydrate binding
GO_0036122	Molecular function	BMP binding
GO_0005515	Molecular function	protein binding
GO_0140678	Molecular function	molecular function inhibitor activity

Gene name	SOST
Protein name	Sclerostin
Synonyms	UNQ2976/PRO7455/PRO7476
Description	FUNCTION: Negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation. .
Accessions	Q9BQB4 ENST00000301691.3 [Q9BQB4-1]

SOST report