STK3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0050673Biological processepithelial cell proliferation
GO_0035265Biological processorgan growth
GO_0007254Biological processJNK cascade
GO_0001841Biological processneural tube formation
GO_0051091Biological processpositive regulation of DNA-binding transcription factor activity
GO_0035329Biological processhippo signaling
GO_0046330Biological processpositive regulation of JNK cascade
GO_0032092Biological processpositive regulation of protein binding
GO_0008625Biological processextrinsic apoptotic signaling pathway via death domain receptors
GO_0071539Biological processprotein localization to centrosome
GO_1902043Biological processpositive regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO_0046621Biological processnegative regulation of organ growth
GO_0003157Biological processendocardium development
GO_0090090Biological processnegative regulation of canonical Wnt signaling pathway
GO_0050680Biological processnegative regulation of epithelial cell proliferation
GO_0060070Biological processcanonical Wnt signaling pathway
GO_0051262Biological processprotein tetramerization
GO_0035556Biological processintracellular signal transduction
GO_0050821Biological processprotein stabilization
GO_0097284Biological processhepatocyte apoptotic process
GO_0045600Biological processpositive regulation of fat cell differentiation
GO_0006606Biological processprotein import into nucleus
GO_0043491Biological processphosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0007417Biological processcentral nervous system development
GO_0060706Biological processcell differentiation involved in embryonic placenta development
GO_0006915Biological processapoptotic process
GO_0051897Biological processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0060800Biological processregulation of cell differentiation involved in embryonic placenta development
GO_0006468Biological processprotein phosphorylation
GO_0043408Biological processregulation of MAPK cascade
GO_0043065Biological processpositive regulation of apoptotic process
GO_0060215Biological processprimitive hemopoiesis
GO_0005813Cellular componentcentrosome
GO_0032991Cellular componentprotein-containing complex
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0106310Molecular functionprotein serine kinase activity
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0042802Molecular functionidentical protein binding
GO_0000287Molecular functionmagnesium ion binding
GO_0004672Molecular functionprotein kinase activity
GO_0043539Molecular functionprotein serine/threonine kinase activator activity
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSTK3
Protein nameSerine/threonine-protein kinase 3 (EC 2.7.11.1)
Serine/threonine-protein kinase 3 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 2) (MST-2) (STE20-like kinase MST2) (Serine/threonine-protein kinase Krs-1) [Cleaved into: Serine/threonine-protein kinase 3 36kDa subunit (MST2/N); Serine/threonine-protein kinase 3 20kDa subunit (MST2/C)]
Serine/threonine kinase 3 (cDNA FLJ90748 fis, clone PLACE1011824, highly similar to Human Ste20-like kinase (MST2) mRNA)
Serine/threonine kinase 3
SynonymsKRS1
MST2
DescriptionFUNCTION: Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ . Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation. Phosphorylates NKX2-1 (By similarity). Phosphorylates NEK2 and plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosome, and its ability to phosphorylate CROCC and CEP250 . In conjunction with SAV1, activates the transcriptional activity of ESR1 through the modulation of its phosphorylation. Positively regulates RAF1 activation via suppression of the inhibitory phosphorylation of RAF1 on 'Ser-259'. Phosphorylates MOBKL1A and RASSF2. Phosphorylates MOBKL1B on 'Thr-74'. Acts cooperatively with MOBKL1B to activate STK38. .

AccessionsENST00000523601.5 [Q13188-2]
Q8NBU1
E5RIM6
ENST00000617590.1
ENST00000424861.6
ENST00000518165.5
Q13188
E5RFQ9
ENST00000521649.5
ENST00000419617.7 [Q13188-1]
A0A087WZ06