Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 27 studies | 40% ± 16% | |
fibroblast | 20 studies | 39% ± 19% | |
astrocyte | 19 studies | 43% ± 21% | |
microglial cell | 15 studies | 46% ± 17% | |
oligodendrocyte | 14 studies | 40% ± 17% | |
smooth muscle cell | 13 studies | 33% ± 13% | |
pericyte | 13 studies | 36% ± 17% | |
macrophage | 11 studies | 44% ± 18% | |
myeloid cell | 9 studies | 27% ± 13% | |
adipocyte | 9 studies | 56% ± 12% | |
endothelial cell of lymphatic vessel | 9 studies | 43% ± 20% | |
oligodendrocyte precursor cell | 8 studies | 26% ± 9% | |
epithelial cell | 7 studies | 39% ± 17% | |
type I pneumocyte | 7 studies | 42% ± 19% | |
basal cell | 7 studies | 40% ± 23% | |
mast cell | 6 studies | 23% ± 7% | |
ciliated cell | 6 studies | 30% ± 11% | |
type II pneumocyte | 6 studies | 43% ± 14% | |
GABAergic neuron | 5 studies | 38% ± 17% | |
cardiac muscle cell | 5 studies | 38% ± 10% | |
dendritic cell | 5 studies | 30% ± 4% | |
connective tissue cell | 5 studies | 27% ± 8% | |
monocyte | 5 studies | 37% ± 10% | |
club cell | 5 studies | 44% ± 18% | |
cholangiocyte | 4 studies | 53% ± 21% | |
hepatocyte | 4 studies | 61% ± 32% | |
mesothelial cell | 4 studies | 33% ± 12% | |
vein endothelial cell | 4 studies | 41% ± 24% | |
Mueller cell | 4 studies | 40% ± 13% | |
muscle cell | 4 studies | 38% ± 21% | |
myofibroblast cell | 4 studies | 35% ± 19% | |
endothelial cell of artery | 3 studies | 24% ± 6% | |
retina horizontal cell | 3 studies | 23% ± 10% | |
retinal rod cell | 3 studies | 34% ± 9% | |
endothelial cell of vascular tree | 3 studies | 51% ± 22% | |
retinal pigment epithelial cell | 3 studies | 37% ± 23% | |
glutamatergic neuron | 3 studies | 63% ± 11% | |
ependymal cell | 3 studies | 54% ± 11% | |
alveolar macrophage | 3 studies | 47% ± 11% | |
capillary endothelial cell | 3 studies | 35% ± 8% | |
respiratory goblet cell | 3 studies | 51% ± 18% | |
mucus secreting cell | 3 studies | 38% ± 6% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
breast | 100% | 1868.08 | 459 / 459 | 100% | 11.99 | 1116 / 1118 |
lung | 100% | 1655.66 | 578 / 578 | 100% | 9.37 | 1150 / 1155 |
esophagus | 100% | 1370.90 | 1445 / 1445 | 99% | 9.06 | 182 / 183 |
prostate | 100% | 1816.80 | 245 / 245 | 99% | 9.35 | 499 / 502 |
uterus | 100% | 2459.72 | 170 / 170 | 99% | 9.45 | 456 / 459 |
ovary | 100% | 2298.87 | 180 / 180 | 99% | 8.08 | 425 / 430 |
pancreas | 99% | 700.27 | 326 / 328 | 98% | 7.53 | 174 / 178 |
bladder | 100% | 1914.62 | 21 / 21 | 96% | 7.39 | 486 / 504 |
stomach | 100% | 978.72 | 359 / 359 | 96% | 6.80 | 275 / 286 |
thymus | 100% | 1205.39 | 652 / 653 | 96% | 5.31 | 578 / 605 |
kidney | 100% | 1325.93 | 89 / 89 | 95% | 5.98 | 859 / 901 |
intestine | 100% | 1375.76 | 965 / 966 | 94% | 6.25 | 498 / 527 |
skin | 100% | 1304.28 | 1809 / 1809 | 92% | 6.86 | 436 / 472 |
liver | 100% | 914.18 | 226 / 226 | 92% | 4.91 | 375 / 406 |
brain | 76% | 366.18 | 2009 / 2642 | 89% | 3.56 | 624 / 705 |
adrenal gland | 100% | 1867.52 | 258 / 258 | 57% | 2.73 | 131 / 230 |
adipose | 100% | 1958.54 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 1828.00 | 1335 / 1335 | 0% | 0 | 0 / 0 |
spleen | 100% | 870.96 | 241 / 241 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 100% | 5.96 | 1 / 1 |
muscle | 100% | 942.58 | 802 / 803 | 0% | 0 | 0 / 0 |
heart | 98% | 803.71 | 843 / 861 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 98% | 7.96 | 44 / 45 |
peripheral blood | 72% | 589.97 | 672 / 929 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 71% | 4.19 | 57 / 80 |
lymph node | 0% | 0 | 0 / 0 | 62% | 2.10 | 18 / 29 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0050673 | Biological process | epithelial cell proliferation |
GO_0035265 | Biological process | organ growth |
GO_0007254 | Biological process | JNK cascade |
GO_0001841 | Biological process | neural tube formation |
GO_0051091 | Biological process | positive regulation of DNA-binding transcription factor activity |
GO_0035329 | Biological process | hippo signaling |
GO_0046330 | Biological process | positive regulation of JNK cascade |
GO_0032092 | Biological process | positive regulation of protein binding |
GO_0008625 | Biological process | extrinsic apoptotic signaling pathway via death domain receptors |
GO_0071539 | Biological process | protein localization to centrosome |
GO_1902043 | Biological process | positive regulation of extrinsic apoptotic signaling pathway via death domain receptors |
GO_0046621 | Biological process | negative regulation of organ growth |
GO_0003157 | Biological process | endocardium development |
GO_0090090 | Biological process | negative regulation of canonical Wnt signaling pathway |
GO_0050680 | Biological process | negative regulation of epithelial cell proliferation |
GO_0060070 | Biological process | canonical Wnt signaling pathway |
GO_0051262 | Biological process | protein tetramerization |
GO_0035556 | Biological process | intracellular signal transduction |
GO_0050821 | Biological process | protein stabilization |
GO_0097284 | Biological process | hepatocyte apoptotic process |
GO_0045600 | Biological process | positive regulation of fat cell differentiation |
GO_0006606 | Biological process | protein import into nucleus |
GO_0043491 | Biological process | phosphatidylinositol 3-kinase/protein kinase B signal transduction |
GO_0007417 | Biological process | central nervous system development |
GO_0060706 | Biological process | cell differentiation involved in embryonic placenta development |
GO_0006915 | Biological process | apoptotic process |
GO_0051897 | Biological process | positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction |
GO_0060800 | Biological process | regulation of cell differentiation involved in embryonic placenta development |
GO_0006468 | Biological process | protein phosphorylation |
GO_0043408 | Biological process | regulation of MAPK cascade |
GO_0043065 | Biological process | positive regulation of apoptotic process |
GO_0060215 | Biological process | primitive hemopoiesis |
GO_0005813 | Cellular component | centrosome |
GO_0032991 | Cellular component | protein-containing complex |
GO_0005829 | Cellular component | cytosol |
GO_0005737 | Cellular component | cytoplasm |
GO_0005634 | Cellular component | nucleus |
GO_0106310 | Molecular function | protein serine kinase activity |
GO_0004674 | Molecular function | protein serine/threonine kinase activity |
GO_0042802 | Molecular function | identical protein binding |
GO_0000287 | Molecular function | magnesium ion binding |
GO_0004672 | Molecular function | protein kinase activity |
GO_0043539 | Molecular function | protein serine/threonine kinase activator activity |
GO_0005524 | Molecular function | ATP binding |
GO_0005515 | Molecular function | protein binding |
Gene name | STK3 |
Protein name | Serine/threonine-protein kinase 3 (EC 2.7.11.1) Serine/threonine-protein kinase 3 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 2) (MST-2) (STE20-like kinase MST2) (Serine/threonine-protein kinase Krs-1) [Cleaved into: Serine/threonine-protein kinase 3 36kDa subunit (MST2/N); Serine/threonine-protein kinase 3 20kDa subunit (MST2/C)] Serine/threonine kinase 3 (cDNA FLJ90748 fis, clone PLACE1011824, highly similar to Human Ste20-like kinase (MST2) mRNA) Serine/threonine kinase 3 |
Synonyms | KRS1 MST2 |
Description | FUNCTION: Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ . Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation. Phosphorylates NKX2-1 (By similarity). Phosphorylates NEK2 and plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosome, and its ability to phosphorylate CROCC and CEP250 . In conjunction with SAV1, activates the transcriptional activity of ESR1 through the modulation of its phosphorylation. Positively regulates RAF1 activation via suppression of the inhibitory phosphorylation of RAF1 on 'Ser-259'. Phosphorylates MOBKL1A and RASSF2. Phosphorylates MOBKL1B on 'Thr-74'. Acts cooperatively with MOBKL1B to activate STK38. . |
Accessions | ENST00000523601.5 [Q13188-2] Q8NBU1 E5RIM6 ENST00000617590.1 ENST00000424861.6 ENST00000518165.5 Q13188 E5RFQ9 ENST00000521649.5 ENST00000419617.7 [Q13188-1] A0A087WZ06 |