Interactors | Protein name | Directionality | Classification | |
|---|---|---|---|---|
| 1 | NGF-SORT1 | NGF_HUMAN - SORT_HUMAN | Ligand-Receptor | Signaling by Beta-nerve growth factor |
| 2 | TNF-TNFRSF1A | TNFA_HUMAN - TNR1A_HUMAN | Ligand-Receptor | Signaling by Tumor necrosis factor |
| Name | extrinsic apoptotic signaling pathway via death domain receptors |
| ID | GO_0008625 |
| collection_id | Biological process |
| Exact synonym | induction of apoptosis via death receptors |
| Description | The series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with a ligand binding to a death domain receptor on the cell surface, and ends when the execution phase of apoptosis is triggered. |
| Related synonym | induction of apoptosis via death domain receptors |
| Comment | Gene products that may be annotated to this term include: 1) ligands such as FASL; 2) receptors such as FAS/CD95 (though care should be taken because FAS can also act as a non-apoptotic signal transducer); 3) signaling molecules such as FADD (FAS-associated protein with a death domain), cIAPs (cellular inhibitor of apoptosis proteins), c-FLIPs and caspases 8 and 10. Examples are TWEAK (TNF12) and FN14 (TNFRSF12A) (UniProt symbols O43508 and Q9NP84) in PMID:21525013. |
| External URL | |
| Genes |