DAB2IP | OmnibusX

Name	Number of supported studies	Average coverage
endothelial cell	15 studies	30% ± 12%	Explore
astrocyte	7 studies	28% ± 12%	Explore
epithelial cell	6 studies	22% ± 5%	Explore
type I pneumocyte	5 studies	18% ± 2%	Explore
glutamatergic neuron	4 studies	39% ± 12%	Explore
adipocyte	4 studies	19% ± 4%	Explore
cardiac muscle cell	4 studies	22% ± 4%	Explore
Mueller cell	4 studies	38% ± 10%	Explore
basal cell	3 studies	23% ± 7%	Explore
GABAergic neuron	3 studies	36% ± 4%	Explore
oligodendrocyte precursor cell	3 studies	27% ± 8%	Explore
endothelial cell of artery	3 studies	19% ± 5%	Explore
endothelial cell of lymphatic vessel	3 studies	26% ± 7%	Explore
smooth muscle cell	3 studies	22% ± 3%	Explore
fibroblast	3 studies	22% ± 8%	Explore
transit amplifying cell	3 studies	23% ± 8%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	6 studies	28% ± 10%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	100%	13150.03	2637 / 2642	100%	46.28	702 / 705
kidney	100%	8671.29	89 / 89	99%	44.53	895 / 901
esophagus	100%	8292.60	1445 / 1445	99%	57.84	181 / 183
intestine	100%	10210.54	966 / 966	99%	42.57	521 / 527
thymus	100%	6222.53	652 / 653	99%	50.69	597 / 605
uterus	100%	11376.11	170 / 170	98%	35.88	450 / 459
stomach	100%	7015.96	359 / 359	98%	46.05	280 / 286
prostate	100%	7805.76	245 / 245	97%	21.84	487 / 502
ovary	100%	8270.00	180 / 180	97%	31.01	417 / 430
breast	100%	9128.64	459 / 459	96%	26.22	1075 / 1118
bladder	100%	6994.67	21 / 21	96%	30.50	483 / 504
lung	100%	9053.76	576 / 578	96%	29.27	1108 / 1155
skin	98%	6020.20	1768 / 1809	97%	35.63	460 / 472
pancreas	95%	3241.09	310 / 328	99%	36.26	177 / 178
adrenal gland	100%	5058.25	258 / 258	89%	33.77	204 / 230
liver	81%	1874.44	184 / 226	73%	15.49	296 / 406
adipose	100%	7029.11	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	50.14	80 / 80
spleen	100%	6884.96	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	47.95	45 / 45
ureter	0%	0	0 / 0	100%	21.64	1 / 1
blood vessel	100%	10328.02	1334 / 1335	0%	0	0 / 0
muscle	100%	5968.86	802 / 803	0%	0	0 / 0
heart	100%	5312.54	858 / 861	0%	0	0 / 0
lymph node	0%	0	0 / 0	38%	4.38	11 / 29
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
peripheral blood	0%	0	0 / 929	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0006954	Biological process	inflammatory response
GO_0048147	Biological process	negative regulation of fibroblast proliferation
GO_0010976	Biological process	positive regulation of neuron projection development
GO_0071364	Biological process	cellular response to epidermal growth factor stimulus
GO_0021819	Biological process	layer formation in cerebral cortex
GO_0030948	Biological process	negative regulation of vascular endothelial growth factor receptor signaling pathway
GO_0090090	Biological process	negative regulation of canonical Wnt signaling pathway
GO_0032088	Biological process	negative regulation of NF-kappaB transcription factor activity
GO_0031334	Biological process	positive regulation of protein-containing complex assembly
GO_0030163	Biological process	protein catabolic process
GO_0043407	Biological process	negative regulation of MAP kinase activity
GO_2001235	Biological process	positive regulation of apoptotic signaling pathway
GO_0035924	Biological process	cellular response to vascular endothelial growth factor stimulus
GO_0051726	Biological process	regulation of cell cycle
GO_0042177	Biological process	negative regulation of protein catabolic process
GO_0001525	Biological process	angiogenesis
GO_0008285	Biological process	negative regulation of cell population proliferation
GO_1901800	Biological process	positive regulation of proteasomal protein catabolic process
GO_0045087	Biological process	innate immune response
GO_1903896	Biological process	positive regulation of IRE1-mediated unfolded protein response
GO_0071347	Biological process	cellular response to interleukin-1
GO_0035148	Biological process	tube formation
GO_0046580	Biological process	negative regulation of Ras protein signal transduction
GO_0072577	Biological process	endothelial cell apoptotic process
GO_0045732	Biological process	positive regulation of protein catabolic process
GO_1900006	Biological process	positive regulation of dendrite development
GO_0043087	Biological process	regulation of GTPase activity
GO_1900744	Biological process	regulation of p38MAPK cascade
GO_0071222	Biological process	cellular response to lipopolysaccharide
GO_0090129	Biological process	positive regulation of synapse maturation
GO_0043122	Biological process	regulation of canonical NF-kappaB signal transduction
GO_0043124	Biological process	negative regulation of canonical NF-kappaB signal transduction
GO_0070059	Biological process	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO_0034620	Biological process	cellular response to unfolded protein
GO_0034260	Biological process	negative regulation of GTPase activity
GO_2001224	Biological process	positive regulation of neuron migration
GO_0070373	Biological process	negative regulation of ERK1 and ERK2 cascade
GO_0008625	Biological process	extrinsic apoptotic signaling pathway via death domain receptors
GO_0048812	Biological process	neuron projection morphogenesis
GO_1900747	Biological process	negative regulation of vascular endothelial growth factor signaling pathway
GO_0043254	Biological process	regulation of protein-containing complex assembly
GO_0010633	Biological process	negative regulation of epithelial cell migration
GO_0043065	Biological process	positive regulation of apoptotic process
GO_0045892	Biological process	negative regulation of DNA-templated transcription
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_0071901	Biological process	negative regulation of protein serine/threonine kinase activity
GO_0043507	Biological process	positive regulation of JUN kinase activity
GO_0042059	Biological process	negative regulation of epidermal growth factor receptor signaling pathway
GO_0046330	Biological process	positive regulation of JNK cascade
GO_0034144	Biological process	negative regulation of toll-like receptor 4 signaling pathway
GO_0070317	Biological process	negative regulation of G0 to G1 transition
GO_0043410	Biological process	positive regulation of MAPK cascade
GO_0000122	Biological process	negative regulation of transcription by RNA polymerase II
GO_0021814	Biological process	cell motility involved in cerebral cortex radial glia guided migration
GO_0050680	Biological process	negative regulation of epithelial cell proliferation
GO_0051898	Biological process	negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0016525	Biological process	negative regulation of angiogenesis
GO_0071356	Biological process	cellular response to tumor necrosis factor
GO_0035556	Biological process	intracellular signal transduction
GO_0010719	Biological process	negative regulation of epithelial to mesenchymal transition
GO_0043123	Biological process	positive regulation of canonical NF-kappaB signal transduction
GO_0010596	Biological process	negative regulation of endothelial cell migration
GO_0036324	Biological process	vascular endothelial growth factor receptor-2 signaling pathway
GO_0071902	Biological process	positive regulation of protein serine/threonine kinase activity
GO_0030139	Cellular component	endocytic vesicle
GO_0043025	Cellular component	neuronal cell body
GO_1990032	Cellular component	parallel fiber
GO_0044301	Cellular component	climbing fiber
GO_0030425	Cellular component	dendrite
GO_0044300	Cellular component	cerebellar mossy fiber
GO_0005886	Cellular component	plasma membrane
GO_1990597	Cellular component	AIP1-IRE1 complex
GO_0005737	Cellular component	cytoplasm
GO_0030424	Cellular component	axon
GO_0032809	Cellular component	neuronal cell body membrane
GO_0005829	Cellular component	cytosol
GO_0043548	Molecular function	phosphatidylinositol 3-kinase binding
GO_0031435	Molecular function	mitogen-activated protein kinase kinase kinase binding
GO_0042802	Molecular function	identical protein binding
GO_0043539	Molecular function	protein serine/threonine kinase activator activity
GO_0051721	Molecular function	protein phosphatase 2A binding
GO_0019900	Molecular function	kinase binding
GO_0071889	Molecular function	14-3-3 protein binding
GO_0017124	Molecular function	SH3 domain binding
GO_0031434	Molecular function	mitogen-activated protein kinase kinase binding
GO_0032266	Molecular function	phosphatidylinositol-3-phosphate binding
GO_0043184	Molecular function	vascular endothelial growth factor receptor 2 binding
GO_0005096	Molecular function	GTPase activator activity
GO_0035662	Molecular function	Toll-like receptor 4 binding
GO_0035591	Molecular function	signaling adaptor activity
GO_0005515	Molecular function	protein binding
GO_0070273	Molecular function	phosphatidylinositol-4-phosphate binding
GO_0042803	Molecular function	protein homodimerization activity
GO_0044877	Molecular function	protein-containing complex binding
GO_0045296	Molecular function	cadherin binding
GO_0019901	Molecular function	protein kinase binding
GO_0005123	Molecular function	death receptor binding
GO_0036312	Molecular function	phosphatidylinositol 3-kinase regulatory subunit binding

IV. Literature review

[source]

Gene name	DAB2IP
Protein name	DAB2 interacting protein Disabled homolog 2-interacting protein (DAB2 interaction protein) (DAB2-interacting protein) (ASK-interacting protein 1) (AIP-1) (DOC-2/DAB-2 interactive protein)
Synonyms	AF9Q34 KIAA1743 AIP1
Description	FUNCTION: Functions as a scaffold protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Involved in several processes such as innate immune response, inflammation and cell growth inhibition, apoptosis, cell survival, angiogenesis, cell migration and maturation. Also plays a role in cell cycle checkpoint control; reduces G1 phase cyclin levels resulting in G0/G1 cell cycle arrest. Mediates signal transduction by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF), interferon (IFN) or lipopolysaccharide (LPS). Modulates the balance between phosphatidylinositol 3-kinase (PI3K)-AKT-mediated cell survival and apoptosis stimulated kinase (MAP3K5)-JNK signaling pathways; sequesters both AKT1 and MAP3K5 and counterbalances the activity of each kinase by modulating their phosphorylation status in response to pro-inflammatory stimuli. Acts as a regulator of the endoplasmic reticulum (ER) unfolded protein response (UPR) pathway; specifically involved in transduction of the ER stress-response to the JNK cascade through ERN1. Mediates TNF-alpha-induced apoptosis activation by facilitating dissociation of inhibitor 14-3-3 from MAP3K5; recruits the PP2A phosphatase complex which dephosphorylates MAP3K5 on 'Ser-966', leading to the dissociation of 13-3-3 proteins and activation of the MAP3K5-JNK signaling pathway in endothelial cells. Mediates also TNF/TRAF2-induced MAP3K5-JNK activation, while it inhibits CHUK-NF-kappa-B signaling. Acts a negative regulator in the IFN-gamma-mediated JAK-STAT signaling cascade by inhibiting smooth muscle cell (VSMCs) proliferation and intimal expansion, and thus, prevents graft arteriosclerosis (GA). Acts as a GTPase-activating protein (GAP) for the ADP ribosylation factor 6 (ARF6) and Ras. Promotes hydrolysis of the ARF6-bound GTP and thus, negatively regulates phosphatidylinositol 4,5-bisphosphate (PIP2)-dependent TLR4-TIRAP-MyD88 and NF-kappa-B signaling pathways in endothelial cells in response to lipopolysaccharides (LPS). Binds specifically to phosphatidylinositol 4-phosphate (PtdIns4P) and phosphatidylinositol 3-phosphate (PtdIns3P). In response to vascular endothelial growth factor (VEGFA), acts as a negative regulator of the VEGFR2-PI3K-mediated angiogenic signaling pathway by inhibiting endothelial cell migration and tube formation. In the developing brain, promotes both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex in a glial-dependent locomotion process. Probable downstream effector of the Reelin signaling pathway; promotes Purkinje cell (PC) dendrites development and formation of cerebellar synapses. Functions also as a tumor suppressor protein in prostate cancer progression; prevents cell proliferation and epithelial-to-mesenchymal transition (EMT) through activation of the glycogen synthase kinase-3 beta (GSK3B)-induced beta-catenin and inhibition of PI3K-AKT and Ras-MAPK survival downstream signaling cascades, respectively. .
Accessions	ENST00000648444.1 A0A8V8TNA8 A0A3B3ITG3 F6R503 ENST00000436835.6 ENST00000259371.7 [Q5VWQ8-5] ENST00000648693.1 ENST00000309989.1 [Q5VWQ8-2] ENST00000489314.1 A0A3B3IUB7 ENST00000408936.8 [Q5VWQ8-1] Q5VWQ8 ENST00000699487.1 A0A3B3ITC7

DAB2IP report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review