Name | Number of supported studies | Average coverage | |
---|---|---|---|
macrophage | 22 studies | 35% ± 19% | |
astrocyte | 15 studies | 41% ± 17% | |
non-classical monocyte | 12 studies | 25% ± 6% | |
endothelial cell | 11 studies | 42% ± 21% | |
glutamatergic neuron | 11 studies | 48% ± 23% | |
type I pneumocyte | 10 studies | 44% ± 21% | |
GABAergic neuron | 9 studies | 57% ± 22% | |
epithelial cell | 9 studies | 30% ± 13% | |
myeloid cell | 9 studies | 39% ± 16% | |
dendritic cell | 9 studies | 34% ± 11% | |
mesothelial cell | 9 studies | 42% ± 24% | |
ciliated cell | 8 studies | 30% ± 14% | |
mast cell | 8 studies | 27% ± 11% | |
endothelial cell of lymphatic vessel | 8 studies | 42% ± 14% | |
monocyte | 8 studies | 37% ± 19% | |
plasmacytoid dendritic cell | 7 studies | 22% ± 8% | |
club cell | 7 studies | 44% ± 19% | |
type II pneumocyte | 7 studies | 44% ± 18% | |
interneuron | 6 studies | 56% ± 19% | |
neuron | 5 studies | 40% ± 13% | |
fibroblast | 5 studies | 36% ± 15% | |
classical monocyte | 5 studies | 19% ± 4% | |
Mueller cell | 4 studies | 33% ± 14% | |
retina horizontal cell | 4 studies | 34% ± 13% | |
conventional dendritic cell | 4 studies | 19% ± 3% | |
alveolar macrophage | 4 studies | 52% ± 21% | |
hematopoietic precursor cell | 3 studies | 26% ± 11% | |
cholangiocyte | 3 studies | 48% ± 21% | |
endothelial cell of sinusoid | 3 studies | 32% ± 12% | |
GABAergic interneuron | 3 studies | 53% ± 4% | |
mononuclear phagocyte | 3 studies | 35% ± 10% | |
GABAergic amacrine cell | 3 studies | 39% ± 9% | |
glycinergic amacrine cell | 3 studies | 24% ± 8% | |
intermediate monocyte | 3 studies | 23% ± 5% | |
hepatocyte | 3 studies | 49% ± 20% | |
amacrine cell | 3 studies | 42% ± 15% | |
connective tissue cell | 3 studies | 18% ± 1% | |
ependymal cell | 3 studies | 44% ± 23% | |
megakaryocyte-erythroid progenitor cell | 3 studies | 28% ± 7% | |
smooth muscle cell | 3 studies | 17% ± 2% | |
basal cell | 3 studies | 35% ± 18% | |
brush cell | 3 studies | 23% ± 3% | |
T cell | 3 studies | 36% ± 20% | |
kidney loop of Henle epithelial cell | 3 studies | 29% ± 7% | |
mucus secreting cell | 3 studies | 32% ± 7% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
pancreas | 100% | 4919.84 | 328 / 328 | 97% | 39.57 | 172 / 178 |
kidney | 100% | 4961.73 | 89 / 89 | 91% | 30.12 | 822 / 901 |
lung | 100% | 6813.30 | 577 / 578 | 90% | 25.33 | 1041 / 1155 |
liver | 99% | 3588.19 | 223 / 226 | 88% | 17.33 | 356 / 406 |
ovary | 100% | 13168.12 | 180 / 180 | 84% | 12.59 | 362 / 430 |
prostate | 89% | 1498.30 | 218 / 245 | 94% | 20.67 | 471 / 502 |
bladder | 100% | 3553.10 | 21 / 21 | 81% | 28.32 | 406 / 504 |
brain | 83% | 3008.32 | 2184 / 2642 | 97% | 29.03 | 685 / 705 |
thymus | 100% | 3148.03 | 650 / 653 | 74% | 13.13 | 449 / 605 |
breast | 96% | 1816.75 | 442 / 459 | 75% | 10.97 | 834 / 1118 |
stomach | 100% | 4203.47 | 359 / 359 | 68% | 14.82 | 195 / 286 |
uterus | 98% | 2588.41 | 166 / 170 | 65% | 14.12 | 300 / 459 |
skin | 69% | 1067.09 | 1242 / 1809 | 93% | 28.38 | 438 / 472 |
intestine | 99% | 5503.79 | 961 / 966 | 59% | 12.22 | 309 / 527 |
esophagus | 80% | 4105.53 | 1150 / 1445 | 72% | 19.46 | 132 / 183 |
adrenal gland | 76% | 1104.45 | 197 / 258 | 62% | 9.23 | 142 / 230 |
ureter | 0% | 0 | 0 / 0 | 100% | 36.20 | 1 / 1 |
spleen | 100% | 5220.58 | 240 / 241 | 0% | 0 | 0 / 0 |
adipose | 100% | 4384.90 | 1198 / 1204 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 91% | 15.91 | 73 / 80 |
blood vessel | 84% | 1507.16 | 1120 / 1335 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 69% | 11.34 | 20 / 29 |
peripheral blood | 69% | 1699.88 | 639 / 929 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 58% | 5.62 | 26 / 45 |
heart | 36% | 546.35 | 310 / 861 | 0% | 0 | 0 / 0 |
muscle | 6% | 60.19 | 48 / 803 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0097190 | Biological process | apoptotic signaling pathway |
GO_0071447 | Biological process | cellular response to hydroperoxide |
GO_2000310 | Biological process | regulation of NMDA receptor activity |
GO_0008625 | Biological process | extrinsic apoptotic signaling pathway via death domain receptors |
GO_1904094 | Biological process | positive regulation of autophagic cell death |
GO_0043280 | Biological process | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process |
GO_0002834 | Biological process | regulation of response to tumor cell |
GO_0035556 | Biological process | intracellular signal transduction |
GO_0042981 | Biological process | regulation of apoptotic process |
GO_0043066 | Biological process | negative regulation of apoptotic process |
GO_0010506 | Biological process | regulation of autophagy |
GO_0010508 | Biological process | positive regulation of autophagy |
GO_0002357 | Biological process | defense response to tumor cell |
GO_0006915 | Biological process | apoptotic process |
GO_0006468 | Biological process | protein phosphorylation |
GO_0046777 | Biological process | protein autophosphorylation |
GO_0043065 | Biological process | positive regulation of apoptotic process |
GO_0017148 | Biological process | negative regulation of translation |
GO_0071346 | Biological process | cellular response to type II interferon |
GO_0098978 | Cellular component | glutamatergic synapse |
GO_0005886 | Cellular component | plasma membrane |
GO_1990722 | Cellular component | DAPK1-calmodulin complex |
GO_0015629 | Cellular component | actin cytoskeleton |
GO_0014069 | Cellular component | postsynaptic density |
GO_0005737 | Cellular component | cytoplasm |
GO_0005634 | Cellular component | nucleus |
GO_0106310 | Molecular function | protein serine kinase activity |
GO_0004674 | Molecular function | protein serine/threonine kinase activity |
GO_0042802 | Molecular function | identical protein binding |
GO_0004672 | Molecular function | protein kinase activity |
GO_0005525 | Molecular function | GTP binding |
GO_0017075 | Molecular function | syntaxin-1 binding |
GO_0005524 | Molecular function | ATP binding |
GO_0004683 | Molecular function | calmodulin-dependent protein kinase activity |
GO_0005516 | Molecular function | calmodulin binding |
GO_0005515 | Molecular function | protein binding |
Gene name | DAPK1 |
Protein name | Death-associated protein kinase beta Death-associated protein kinase 1 (DAP kinase 1) (EC 2.7.11.1) Death associated protein kinase 1 |
Synonyms | DAPK |
Description | FUNCTION: Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell deaths signal, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Phosphorylates PIN1 resulting in inhibition of its catalytic activity, nuclear localization, and cellular function. Phosphorylates TPM1, enhancing stress fiber formation in endothelial cells. Phosphorylates STX1A and significantly decreases its binding to STXBP1. Phosphorylates PRKD1 and regulates JNK signaling by binding and activating PRKD1 under oxidative stress. Phosphorylates BECN1, reducing its interaction with BCL2 and BCL2L1 and promoting the induction of autophagy. Phosphorylates TSC2, disrupting the TSC1-TSC2 complex and stimulating mTORC1 activity in a growth factor-dependent pathway. Phosphorylates RPS6, MYL9 and DAPK3. Acts as a signaling amplifier of NMDA receptors at extrasynaptic sites for mediating brain damage in stroke. Cerebral ischemia recruits DAPK1 into the NMDA receptor complex and it phosphorylates GRINB at Ser-1303 inducing injurious Ca(2+) influx through NMDA receptor channels, resulting in an irreversible neuronal death. Required together with DAPK3 for phosphorylation of RPL13A upon interferon-gamma activation which is causing RPL13A involvement in transcript-selective translation inhibition.; FUNCTION: Isoform 2 cannot induce apoptosis but can induce membrane blebbing. |
Accessions | ENST00000489291.5 P53355 ENST00000469640.6 [P53355-4] F8WCQ3 ENST00000358077.9 [P53355-1] ENST00000622514.4 [P53355-1] A0T398 ENST00000472284.5 [P53355-1] ENST00000408954.8 [P53355-1] ENST00000491893.5 [P53355-4] |