DAPK1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0097190Biological processapoptotic signaling pathway
GO_0071447Biological processcellular response to hydroperoxide
GO_2000310Biological processregulation of NMDA receptor activity
GO_0008625Biological processextrinsic apoptotic signaling pathway via death domain receptors
GO_1904094Biological processpositive regulation of autophagic cell death
GO_0043280Biological processpositive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO_0002834Biological processregulation of response to tumor cell
GO_0035556Biological processintracellular signal transduction
GO_0042981Biological processregulation of apoptotic process
GO_0043066Biological processnegative regulation of apoptotic process
GO_0010506Biological processregulation of autophagy
GO_0010508Biological processpositive regulation of autophagy
GO_0002357Biological processdefense response to tumor cell
GO_0006915Biological processapoptotic process
GO_0006468Biological processprotein phosphorylation
GO_0046777Biological processprotein autophosphorylation
GO_0043065Biological processpositive regulation of apoptotic process
GO_0017148Biological processnegative regulation of translation
GO_0071346Biological processcellular response to type II interferon
GO_0098978Cellular componentglutamatergic synapse
GO_0005886Cellular componentplasma membrane
GO_1990722Cellular componentDAPK1-calmodulin complex
GO_0015629Cellular componentactin cytoskeleton
GO_0014069Cellular componentpostsynaptic density
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0106310Molecular functionprotein serine kinase activity
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0042802Molecular functionidentical protein binding
GO_0004672Molecular functionprotein kinase activity
GO_0005525Molecular functionGTP binding
GO_0017075Molecular functionsyntaxin-1 binding
GO_0005524Molecular functionATP binding
GO_0004683Molecular functioncalmodulin-dependent protein kinase activity
GO_0005516Molecular functioncalmodulin binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameDAPK1
Protein nameDeath-associated protein kinase beta
Death-associated protein kinase 1 (DAP kinase 1) (EC 2.7.11.1)
Death associated protein kinase 1
SynonymsDAPK
DescriptionFUNCTION: Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell deaths signal, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Phosphorylates PIN1 resulting in inhibition of its catalytic activity, nuclear localization, and cellular function. Phosphorylates TPM1, enhancing stress fiber formation in endothelial cells. Phosphorylates STX1A and significantly decreases its binding to STXBP1. Phosphorylates PRKD1 and regulates JNK signaling by binding and activating PRKD1 under oxidative stress. Phosphorylates BECN1, reducing its interaction with BCL2 and BCL2L1 and promoting the induction of autophagy. Phosphorylates TSC2, disrupting the TSC1-TSC2 complex and stimulating mTORC1 activity in a growth factor-dependent pathway. Phosphorylates RPS6, MYL9 and DAPK3. Acts as a signaling amplifier of NMDA receptors at extrasynaptic sites for mediating brain damage in stroke. Cerebral ischemia recruits DAPK1 into the NMDA receptor complex and it phosphorylates GRINB at Ser-1303 inducing injurious Ca(2+) influx through NMDA receptor channels, resulting in an irreversible neuronal death. Required together with DAPK3 for phosphorylation of RPL13A upon interferon-gamma activation which is causing RPL13A involvement in transcript-selective translation inhibition.; FUNCTION: Isoform 2 cannot induce apoptosis but can induce membrane blebbing.

AccessionsENST00000489291.5
P53355
ENST00000469640.6 [P53355-4]
F8WCQ3
ENST00000358077.9 [P53355-1]
ENST00000622514.4 [P53355-1]
A0T398
ENST00000472284.5 [P53355-1]
ENST00000408954.8 [P53355-1]
ENST00000491893.5 [P53355-4]