Insufficient scRNA-seq data for expression of FADD at single-cell level.
Insufficient scRNA-seq data for expression of FADD at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 99% | 236.72 | 1434 / 1445 | 100% | 31.49 | 183 / 183 |
stomach | 99% | 167.06 | 355 / 359 | 99% | 13.75 | 284 / 286 |
intestine | 99% | 244.59 | 960 / 966 | 98% | 13.06 | 517 / 527 |
ovary | 96% | 155.57 | 173 / 180 | 100% | 16.35 | 430 / 430 |
skin | 100% | 330.40 | 1805 / 1809 | 95% | 7.96 | 450 / 472 |
lung | 98% | 183.68 | 565 / 578 | 95% | 8.42 | 1095 / 1155 |
bladder | 100% | 225.71 | 21 / 21 | 92% | 9.04 | 466 / 504 |
breast | 100% | 236.50 | 457 / 459 | 92% | 7.92 | 1033 / 1118 |
uterus | 100% | 231.38 | 170 / 170 | 90% | 6.57 | 412 / 459 |
thymus | 99% | 173.69 | 647 / 653 | 89% | 5.63 | 541 / 605 |
kidney | 100% | 218.25 | 89 / 89 | 87% | 5.26 | 780 / 901 |
prostate | 100% | 158.52 | 244 / 245 | 87% | 3.61 | 435 / 502 |
pancreas | 92% | 99.84 | 303 / 328 | 93% | 5.80 | 165 / 178 |
brain | 92% | 99.49 | 2420 / 2642 | 85% | 4.96 | 597 / 705 |
liver | 96% | 131.71 | 216 / 226 | 74% | 3.44 | 299 / 406 |
adrenal gland | 100% | 306.41 | 257 / 258 | 66% | 2.49 | 151 / 230 |
spleen | 100% | 251.92 | 241 / 241 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 100% | 4.14 | 1 / 1 |
adipose | 100% | 215.75 | 1201 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 99% | 183.07 | 1320 / 1335 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 99% | 7.55 | 79 / 80 |
peripheral blood | 97% | 510.28 | 904 / 929 | 0% | 0 | 0 / 0 |
muscle | 94% | 116.36 | 752 / 803 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 91% | 9.71 | 41 / 45 |
lymph node | 0% | 0 | 0 / 0 | 90% | 7.13 | 26 / 29 |
heart | 86% | 99.89 | 743 / 861 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0097191 | Biological process | extrinsic apoptotic signaling pathway |
GO_0043029 | Biological process | T cell homeostasis |
GO_0042104 | Biological process | positive regulation of activated T cell proliferation |
GO_0097190 | Biological process | apoptotic signaling pathway |
GO_2001238 | Biological process | positive regulation of extrinsic apoptotic signaling pathway |
GO_0071260 | Biological process | cellular response to mechanical stimulus |
GO_0045651 | Biological process | positive regulation of macrophage differentiation |
GO_0060340 | Biological process | positive regulation of type I interferon-mediated signaling pathway |
GO_0045862 | Biological process | positive regulation of proteolysis |
GO_0048535 | Biological process | lymph node development |
GO_0045087 | Biological process | innate immune response |
GO_0070236 | Biological process | negative regulation of activation-induced cell death of T cells |
GO_0051607 | Biological process | defense response to virus |
GO_0008625 | Biological process | extrinsic apoptotic signaling pathway via death domain receptors |
GO_0036462 | Biological process | TRAIL-activated apoptotic signaling pathway |
GO_0001822 | Biological process | kidney development |
GO_0097202 | Biological process | activation of cysteine-type endopeptidase activity |
GO_0045089 | Biological process | positive regulation of innate immune response |
GO_0001916 | Biological process | positive regulation of T cell mediated cytotoxicity |
GO_0048536 | Biological process | spleen development |
GO_0071550 | Biological process | death-inducing signaling complex assembly |
GO_0033077 | Biological process | T cell differentiation in thymus |
GO_0060546 | Biological process | negative regulation of necroptotic process |
GO_0043123 | Biological process | positive regulation of canonical NF-kappaB signal transduction |
GO_0097192 | Biological process | extrinsic apoptotic signaling pathway in absence of ligand |
GO_0048538 | Biological process | thymus development |
GO_0032757 | Biological process | positive regulation of interleukin-8 production |
GO_0002821 | Biological process | positive regulation of adaptive immune response |
GO_0097049 | Biological process | motor neuron apoptotic process |
GO_0097527 | Biological process | necroptotic signaling pathway |
GO_0006915 | Biological process | apoptotic process |
GO_0032729 | Biological process | positive regulation of type II interferon production |
GO_0048148 | Biological process | behavioral response to cocaine |
GO_0043065 | Biological process | positive regulation of apoptotic process |
GO_0032760 | Biological process | positive regulation of tumor necrosis factor production |
GO_1900119 | Biological process | positive regulation of execution phase of apoptosis |
GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
GO_2000454 | Biological process | positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation |
GO_0097342 | Cellular component | ripoptosome |
GO_0005886 | Cellular component | plasma membrane |
GO_0009898 | Cellular component | cytoplasmic side of plasma membrane |
GO_0031265 | Cellular component | CD95 death-inducing signaling complex |
GO_0005829 | Cellular component | cytosol |
GO_0005737 | Cellular component | cytoplasm |
GO_0044297 | Cellular component | cell body |
GO_0031264 | Cellular component | death-inducing signaling complex |
GO_0060090 | Molecular function | molecular adaptor activity |
GO_0044877 | Molecular function | protein-containing complex binding |
GO_0032813 | Molecular function | tumor necrosis factor receptor superfamily binding |
GO_0042802 | Molecular function | identical protein binding |
GO_0002020 | Molecular function | protease binding |
GO_0035591 | Molecular function | signaling adaptor activity |
GO_0033612 | Molecular function | receptor serine/threonine kinase binding |
GO_0005123 | Molecular function | death receptor binding |
GO_0005164 | Molecular function | tumor necrosis factor receptor binding |
GO_0089720 | Molecular function | caspase binding |
GO_0005515 | Molecular function | protein binding |
GO_0035877 | Molecular function | death effector domain binding |
Gene name | FADD |
Protein name | FADD protein FAS-associated death domain protein (FAS-associating death domain-containing protein) (Growth-inhibiting gene 3 protein) (Mediator of receptor induced toxicity) Fas-associating protein |
Synonyms | GIG3 MORT1 |
Description | FUNCTION: Apoptotic adapter molecule that recruits caspases CASP8 or CASP10 to the activated FAS/CD95 or TNFRSF1A/TNFR-1 receptors . The resulting aggregate called the death-inducing signaling complex (DISC) performs CASP8 proteolytic activation . Active CASP8 initiates the subsequent cascade of caspases mediating apoptosis . Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling . . |
Accessions | Q6LCB0 ENST00000301838.5 Q13158 Q6LCG1 |