FADD report

I. Expression across cell types

Insufficient scRNA-seq data for expression of FADD at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of FADD at tissue level.

III. Associated gene sets

GO_0097191Biological processextrinsic apoptotic signaling pathway
GO_0043029Biological processT cell homeostasis
GO_0042104Biological processpositive regulation of activated T cell proliferation
GO_0097190Biological processapoptotic signaling pathway
GO_2001238Biological processpositive regulation of extrinsic apoptotic signaling pathway
GO_0071260Biological processcellular response to mechanical stimulus
GO_0045651Biological processpositive regulation of macrophage differentiation
GO_0060340Biological processpositive regulation of type I interferon-mediated signaling pathway
GO_0045862Biological processpositive regulation of proteolysis
GO_0048535Biological processlymph node development
GO_0045087Biological processinnate immune response
GO_0070236Biological processnegative regulation of activation-induced cell death of T cells
GO_0051607Biological processdefense response to virus
GO_0008625Biological processextrinsic apoptotic signaling pathway via death domain receptors
GO_0036462Biological processTRAIL-activated apoptotic signaling pathway
GO_0001822Biological processkidney development
GO_0097202Biological processactivation of cysteine-type endopeptidase activity
GO_0045089Biological processpositive regulation of innate immune response
GO_0001916Biological processpositive regulation of T cell mediated cytotoxicity
GO_0048536Biological processspleen development
GO_0071550Biological processdeath-inducing signaling complex assembly
GO_0033077Biological processT cell differentiation in thymus
GO_0060546Biological processnegative regulation of necroptotic process
GO_0043123Biological processpositive regulation of canonical NF-kappaB signal transduction
GO_0097192Biological processextrinsic apoptotic signaling pathway in absence of ligand
GO_0048538Biological processthymus development
GO_0032757Biological processpositive regulation of interleukin-8 production
GO_0002821Biological processpositive regulation of adaptive immune response
GO_0097049Biological processmotor neuron apoptotic process
GO_0097527Biological processnecroptotic signaling pathway
GO_0006915Biological processapoptotic process
GO_0032729Biological processpositive regulation of type II interferon production
GO_0048148Biological processbehavioral response to cocaine
GO_0043065Biological processpositive regulation of apoptotic process
GO_0032760Biological processpositive regulation of tumor necrosis factor production
GO_1900119Biological processpositive regulation of execution phase of apoptosis
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_2000454Biological processpositive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation
GO_0097342Cellular componentripoptosome
GO_0005886Cellular componentplasma membrane
GO_0009898Cellular componentcytoplasmic side of plasma membrane
GO_0031265Cellular componentCD95 death-inducing signaling complex
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0044297Cellular componentcell body
GO_0031264Cellular componentdeath-inducing signaling complex
GO_0060090Molecular functionmolecular adaptor activity
GO_0044877Molecular functionprotein-containing complex binding
GO_0032813Molecular functiontumor necrosis factor receptor superfamily binding
GO_0042802Molecular functionidentical protein binding
GO_0002020Molecular functionprotease binding
GO_0035591Molecular functionsignaling adaptor activity
GO_0033612Molecular functionreceptor serine/threonine kinase binding
GO_0005123Molecular functiondeath receptor binding
GO_0005164Molecular functiontumor necrosis factor receptor binding
GO_0089720Molecular functioncaspase binding
GO_0005515Molecular functionprotein binding
GO_0035877Molecular functiondeath effector domain binding

IV. Literature review

[source]
Gene nameFADD
Protein nameFADD protein
FAS-associated death domain protein (FAS-associating death domain-containing protein) (Growth-inhibiting gene 3 protein) (Mediator of receptor induced toxicity)
Fas-associating protein
SynonymsGIG3
MORT1
DescriptionFUNCTION: Apoptotic adapter molecule that recruits caspases CASP8 or CASP10 to the activated FAS/CD95 or TNFRSF1A/TNFR-1 receptors . The resulting aggregate called the death-inducing signaling complex (DISC) performs CASP8 proteolytic activation . Active CASP8 initiates the subsequent cascade of caspases mediating apoptosis . Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling . .

AccessionsQ6LCB0
ENST00000301838.5
Q13158
Q6LCG1