Interactors | Protein name | Directionality | Classification | |
|---|---|---|---|---|
| 1 | CD70-CD27 | CD70_HUMAN - CD27_HUMAN | Ligand-Receptor | |
| 2 | FASLG-FAS | TNFL6_HUMAN - TNR6_HUMAN | Ligand-Receptor | Signaling by Tumor necrosis factor |
| 3 | INHA+INHBA-ACVR1B+ACVR2A | - | Ligand-Receptor | Signaling by Inhibin/Activin |
| 4 | INHA+INHBA-ACVR1B+ACVR2B | - | Ligand-Receptor | Signaling by Inhibin/Activin |
| 5 | INHBA+INHBB-ACVR1B+ACVR2A | - | Ligand-Receptor | Signaling by Inhibin/Activin |
| 6 | INHBA+INHBB-ACVR1B+ACVR2B | - | Ligand-Receptor | Signaling by Inhibin/Activin |
| 7 | TNF-TNFRSF1B | TNFA_HUMAN - TNR1B_HUMAN | Ligand-Receptor | Signaling by Tumor necrosis factor |
| Name | extrinsic apoptotic signaling pathway |
| ID | GO_0097191 |
| collection_id | Biological process |
| Exact synonym | extrinsic apoptotic pathway, extrinsic apoptotic signalling pathway |
| Description | The series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with either a ligand binding to a cell surface receptor, or a ligand being withdrawn from a cell surface receptor (e.g. in the case of signaling by dependence receptors), and ends when the execution phase of apoptosis is triggered. |
| Comment | Fas acts as a death receptor with a role in apoptosis, but can also act as a non-apoptotic signal transducer. |
| External URL | |
| Genes |