Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| pericyte | 7 studies | 20% ± 3% | |
| fibroblast | 6 studies | 20% ± 6% | |
| smooth muscle cell | 5 studies | 19% ± 3% | |
| natural killer cell | 3 studies | 22% ± 6% | |
| CD16-positive, CD56-dim natural killer cell, human | 3 studies | 19% ± 2% | |
| myeloid cell | 3 studies | 22% ± 7% | |
| endothelial cell | 3 studies | 30% ± 2% |
Insufficient scRNA-seq data for expression of TNFSF12 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| thymus | 100% | 2219.45 | 650 / 653 | 100% | 36.66 | 603 / 605 |
| brain | 99% | 2476.66 | 2627 / 2642 | 100% | 38.84 | 703 / 705 |
| prostate | 100% | 3470.09 | 244 / 245 | 99% | 33.48 | 499 / 502 |
| breast | 100% | 3496.22 | 459 / 459 | 98% | 28.68 | 1093 / 1118 |
| kidney | 99% | 2468.06 | 88 / 89 | 97% | 55.44 | 874 / 901 |
| ovary | 100% | 3380.16 | 180 / 180 | 96% | 16.19 | 412 / 430 |
| skin | 96% | 1372.86 | 1733 / 1809 | 99% | 40.35 | 467 / 472 |
| lung | 100% | 3668.11 | 578 / 578 | 94% | 22.77 | 1082 / 1155 |
| adrenal gland | 99% | 2205.17 | 256 / 258 | 90% | 22.08 | 206 / 230 |
| pancreas | 91% | 1065.04 | 300 / 328 | 97% | 34.41 | 173 / 178 |
| uterus | 99% | 3757.53 | 169 / 170 | 89% | 17.30 | 408 / 459 |
| bladder | 100% | 4118.00 | 21 / 21 | 88% | 18.14 | 441 / 504 |
| intestine | 99% | 4160.07 | 953 / 966 | 88% | 14.53 | 464 / 527 |
| stomach | 98% | 2885.24 | 353 / 359 | 84% | 14.69 | 240 / 286 |
| esophagus | 91% | 4321.69 | 1319 / 1445 | 71% | 8.70 | 130 / 183 |
| liver | 60% | 570.61 | 136 / 226 | 82% | 14.22 | 331 / 406 |
| adipose | 100% | 4037.24 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 6260.05 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 100% | 44.02 | 80 / 80 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 31.79 | 29 / 29 |
| spleen | 100% | 3398.71 | 241 / 241 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 100% | 10.59 | 1 / 1 |
| heart | 99% | 2138.17 | 855 / 861 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 91% | 15.33 | 41 / 45 |
| peripheral blood | 83% | 1263.94 | 769 / 929 | 0% | 0 | 0 / 0 |
| muscle | 67% | 645.29 | 542 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0097191 | Biological process | extrinsic apoptotic signaling pathway |
| GO_0001525 | Biological process | angiogenesis |
| GO_2001238 | Biological process | positive regulation of extrinsic apoptotic signaling pathway |
| GO_0045766 | Biological process | positive regulation of angiogenesis |
| GO_0007165 | Biological process | signal transduction |
| GO_0006955 | Biological process | immune response |
| GO_0045732 | Biological process | positive regulation of protein catabolic process |
| GO_0001938 | Biological process | positive regulation of endothelial cell proliferation |
| GO_0043542 | Biological process | endothelial cell migration |
| GO_0030154 | Biological process | cell differentiation |
| GO_0006915 | Biological process | apoptotic process |
| GO_0005615 | Cellular component | extracellular space |
| GO_0005576 | Cellular component | extracellular region |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0048471 | Cellular component | perinuclear region of cytoplasm |
| GO_0048018 | Molecular function | receptor ligand activity |
| GO_0005102 | Molecular function | signaling receptor binding |
| GO_0005164 | Molecular function | tumor necrosis factor receptor binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0005125 | Molecular function | cytokine activity |
| Gene name | TNFSF12 |
| Protein name | HCG1991317, isoform CRA_a (TNF superfamily member 12) (TNFSF12 protein) Tumor necrosis factor ligand superfamily member 12 (APO3 ligand) (TNF-related weak inducer of apoptosis) (TWEAK) [Cleaved into: Tumor necrosis factor ligand superfamily member 12, membrane form; Tumor necrosis factor ligand superfamily member 12, secreted form] TNF superfamily member 12 HCG1991317, isoform CRA_b (TWEAK) (Tumor necrosis factor (Ligand) superfamily, member 12) HCG1991317, isoform CRA_c (TNF superfamily member 12) (Tumor necrosis factor ligand 4A) |
| Synonyms | TWEAK TNLG4A hCG_1991317 DR3LG APO3L UNQ181/PRO207 |
| Description | FUNCTION: Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in induction of inflammatory cytokines. Promotes IL8 secretion. . |
| Accessions | ENST00000700014.1 A0A8V8TPL4 Q4ACW9 C0H5Y4 A0A8V8TP82 A0A8V8TQK2 A0A8V8TPS2 ENST00000700015.1 ENST00000293825.11 [O43508-1] ENST00000700051.1 A0A0U5J5F5 O43508 A0A8V8TQJ4 A0A8V8TQX4 ENST00000322272.11 ENST00000700053.1 ENST00000700056.1 ENST00000700052.1 ENST00000700054.1 |
