GSK3B report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0030011Biological processmaintenance of cell polarity
GO_0030516Biological processregulation of axon extension
GO_0070885Biological processnegative regulation of calcineurin-NFAT signaling cascade
GO_2000077Biological processnegative regulation of type B pancreatic cell development
GO_0048814Biological processregulation of dendrite morphogenesis
GO_0031333Biological processnegative regulation of protein-containing complex assembly
GO_0046827Biological processpositive regulation of protein export from nucleus
GO_0090090Biological processnegative regulation of canonical Wnt signaling pathway
GO_0031334Biological processpositive regulation of protein-containing complex assembly
GO_0043066Biological processnegative regulation of apoptotic process
GO_0045724Biological processpositive regulation of cilium assembly
GO_0097192Biological processextrinsic apoptotic signaling pathway in absence of ligand
GO_1902042Biological processnegative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO_0006468Biological processprotein phosphorylation
GO_1903566Biological processpositive regulation of protein localization to cilium
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0071300Biological processcellular response to retinoic acid
GO_0032886Biological processregulation of microtubule-based process
GO_1900271Biological processregulation of long-term synaptic potentiation
GO_0043547Biological processpositive regulation of GTPase activity
GO_0010629Biological processnegative regulation of gene expression
GO_0032515Biological processnegative regulation of phosphoprotein phosphatase activity
GO_0031175Biological processneuron projection development
GO_0032436Biological processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO_0010628Biological processpositive regulation of gene expression
GO_0032007Biological processnegative regulation of TOR signaling
GO_0042752Biological processregulation of circadian rhythm
GO_1900034Biological processregulation of cellular response to heat
GO_2000466Biological processnegative regulation of glycogen (starch) synthase activity
GO_0045732Biological processpositive regulation of protein catabolic process
GO_1904781Biological processpositive regulation of protein localization to centrosome
GO_0010508Biological processpositive regulation of autophagy
GO_0099171Biological processpresynaptic modulation of chemical synaptic transmission
GO_0010975Biological processregulation of neuron projection development
GO_0030336Biological processnegative regulation of cell migration
GO_0031398Biological processpositive regulation of protein ubiquitination
GO_0070507Biological processregulation of microtubule cytoskeleton organization
GO_0046777Biological processprotein autophosphorylation
GO_0106027Biological processneuron projection organization
GO_0097191Biological processextrinsic apoptotic signaling pathway
GO_0021766Biological processhippocampus development
GO_0036016Biological processcellular response to interleukin-3
GO_0060079Biological processexcitatory postsynaptic potential
GO_0032092Biological processpositive regulation of protein binding
GO_0018107Biological processpeptidyl-threonine phosphorylation
GO_1904339Biological processnegative regulation of dopaminergic neuron differentiation
GO_0045597Biological processpositive regulation of cell differentiation
GO_0007005Biological processmitochondrion organization
GO_0008286Biological processinsulin receptor signaling pathway
GO_0045668Biological processnegative regulation of osteoblast differentiation
GO_0019082Biological processviral protein processing
GO_1900181Biological processnegative regulation of protein localization to nucleus
GO_1904646Biological processcellular response to amyloid-beta
GO_0030010Biological processestablishment of cell polarity
GO_0018105Biological processpeptidyl-serine phosphorylation
GO_0001837Biological processepithelial to mesenchymal transition
GO_1901030Biological processpositive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
GO_0005977Biological processglycogen metabolic process
GO_0001954Biological processpositive regulation of cell-matrix adhesion
GO_0006983Biological processER overload response
GO_0071109Biological processsuperior temporal gyrus development
GO_0150101Biological processregulation of microtubule anchoring at centrosome
GO_0007623Biological processcircadian rhythm
GO_0060070Biological processcanonical Wnt signaling pathway
GO_0035556Biological processintracellular signal transduction
GO_0030154Biological processcell differentiation
GO_1904886Biological processbeta-catenin destruction complex disassembly
GO_2000740Biological processnegative regulation of mesenchymal stem cell differentiation
GO_0045719Biological processnegative regulation of glycogen biosynthetic process
GO_0046825Biological processregulation of protein export from nucleus
GO_0007212Biological processG protein-coupled dopamine receptor signaling pathway
GO_1901984Biological processnegative regulation of protein acetylation
GO_0050770Biological processregulation of axonogenesis
GO_0098978Cellular componentglutamatergic synapse
GO_0098793Cellular componentpresynapse
GO_0098794Cellular componentpostsynapse
GO_0005634Cellular componentnucleus
GO_0005654Cellular componentnucleoplasm
GO_0030877Cellular componentbeta-catenin destruction complex
GO_0030425Cellular componentdendrite
GO_1990909Cellular componentWnt signalosome
GO_0005886Cellular componentplasma membrane
GO_0005739Cellular componentmitochondrion
GO_0005813Cellular componentcentrosome
GO_0005737Cellular componentcytoplasm
GO_0030424Cellular componentaxon
GO_0005829Cellular componentcytosol
GO_0034452Molecular functiondynactin binding
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0004672Molecular functionprotein kinase activity
GO_0034236Molecular functionprotein kinase A catalytic subunit binding
GO_0005524Molecular functionATP binding
GO_0048156Molecular functiontau protein binding
GO_0106310Molecular functionprotein serine kinase activity
GO_0061629Molecular functionRNA polymerase II-specific DNA-binding transcription factor binding
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0002020Molecular functionprotease binding
GO_0050321Molecular functiontau-protein kinase activity
GO_0002039Molecular functionp53 binding
GO_0005515Molecular functionprotein binding
GO_0019901Molecular functionprotein kinase binding
GO_0008013Molecular functionbeta-catenin binding
GO_0016301Molecular functionkinase activity
GO_0051059Molecular functionNF-kappaB binding

IV. Literature review

[source]
Gene nameGSK3B
Protein nameGlycogen synthase kinase 3 beta
Glycogen synthase kinase-3 beta (GSK-3 beta) (EC 2.7.11.26) (Serine/threonine-protein kinase GSK3B) (EC 2.7.11.1)
Glycogen synthase kinase-3 beta
Glycogen synthase kinase-3 beta (EC 2.7.11.26)
SynonymshCG_1818062
DescriptionFUNCTION: Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), EIF2B, CTNNB1/beta-catenin, APC, AXIN1, DPYSL2/CRMP2, JUN, NFATC1/NFATC, MAPT/TAU and MACF1 . Requires primed phosphorylation of the majority of its substrates . In skeletal muscle, contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis . May also mediate the development of insulin resistance by regulating activation of transcription factors . Regulates protein synthesis by controlling the activity of initiation factor 2B (EIF2BE/EIF2B5) in the same manner as glycogen synthase . In Wnt signaling, GSK3B forms a multimeric complex with APC, AXIN1 and CTNNB1/beta-catenin and phosphorylates the N-terminus of CTNNB1 leading to its degradation mediated by ubiquitin/proteasomes . Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA . Phosphorylates NFATC1/NFATC on conserved serine residues promoting NFATC1/NFATC nuclear export, shutting off NFATC1/NFATC gene regulation, and thereby opposing the action of calcineurin . Phosphorylates MAPT/TAU on 'Thr-548', decreasing significantly MAPT/TAU ability to bind and stabilize microtubules . MAPT/TAU is the principal component of neurofibrillary tangles in Alzheimer disease . Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex . Phosphorylates MACF1, inhibiting its binding to microtubules which is critical for its role in bulge stem cell migration and skin wound repair (By similarity). Probably regulates NF-kappa-B (NFKB1) at the transcriptional level and is required for the NF-kappa-B-mediated anti-apoptotic response to TNF-alpha (TNF/TNFA) (By similarity). Negatively regulates replication in pancreatic beta-cells, resulting in apoptosis, loss of beta-cells and diabetes (By similarity). Through phosphorylation of the anti-apoptotic protein MCL1, may control cell apoptosis in response to growth factors deprivation (By similarity). Phosphorylates MUC1 in breast cancer cells, decreasing the interaction of MUC1 with CTNNB1/beta-catenin . Is necessary for the establishment of neuronal polarity and axon outgrowth . Phosphorylates MARK2, leading to inhibition of its activity (By similarity). Phosphorylates SIK1 at 'Thr-182', leading to sustainment of its activity . Phosphorylates ZC3HAV1 which enhances its antiviral activity . Phosphorylates SNAI1, leading to its BTRC-triggered ubiquitination and proteasomal degradation . Phosphorylates SFPQ at 'Thr-687' upon T-cell activation . Phosphorylates NR1D1 st 'Ser-55' and 'Ser-59' and stabilizes it by protecting it from proteasomal degradation. Regulates the circadian clock via phosphorylation of the major clock components including BMAL1, CLOCK and PER2 . Phosphorylates FBXL2 at 'Thr-404' and primes it for ubiquitination by the SCF(FBXO3) complex and proteasomal degradation (By similarity). Phosphorylates CLOCK AT 'Ser-427' and targets it for proteasomal degradation . Phosphorylates BMAL1 at 'Ser-17' and 'Ser-21' and primes it for ubiquitination and proteasomal degradation . Phosphorylates OGT at 'Ser-3' or 'Ser-4' which positively regulates its activity. Phosphorylates MYCN in neuroblastoma cells which may promote its degradation . Regulates the circadian rhythmicity of hippocampal long-term potentiation and BMAL1 and PER2 expression (By similarity). Acts as a regulator of autophagy by mediating phosphorylation of KAT5/TIP60 under starvation conditions, activating KAT5/TIP60 acetyltransferase activity and promoting acetylation of key autophagy regulators, such as ULK1 and RUBCNL/Pacer . Negatively regulates extrinsic apoptotic signaling pathway via death domain receptors. Promotes the formation of an anti-apoptotic complex, made of DDX3X, BRIC2 and GSK3B, at death receptors, including TNFRSF10B. The anti-apoptotic function is most effective with weak apoptotic signals and can be overcome by stronger stimulation . Phosphorylates E2F1, promoting the interaction between E2F1 and USP11, stabilizing E2F1 and promoting its activity . Phosphorylates mTORC2 complex component RICTOR at 'Thr-1695' which facilitates FBXW7-mediated ubiquitination and subsequent degradation of RICTOR . Phosphorylates FXR1, promoting FXR1 ubiquitination by the SCF(FBXO4) complex and FXR1 degradation by the proteasome (By similarity). Phosphorylates interleukin-22 receptor subunit IL22RA1, preventing its proteasomal degradation (By similarity). .

AccessionsA0A7I2V432
ENST00000677716.1
A0A7I2V2U4
A0A7I2V3G9
ENST00000678509.1
A0A7I2V3S5
ENST00000676910.1
A0A7I2V5B5
ENST00000678787.1
A0A7I2V4F3
A0A7I2V606
A0A7I2V4X3
A0A7I2V5K9
A0A7I2V2Y0
ENST00000677400.1
A0A7I2V3K8
A0A7I2V589
A0A7I2V3J4
ENST00000678350.1
ENST00000677903.1
ENST00000679068.1
A0A7I2V3N7
ENST00000264235.13 [P49841-1]
ENST00000676887.1
ENST00000676775.1
ENST00000677995.1
ENST00000677362.1
ENST00000677885.1
ENST00000679201.1
ENST00000677128.1
ENST00000677875.1
ENST00000679066.1
ENST00000678377.1
ENST00000677169.1
A0A7I2V4G2
A0A7I2YQG6
A0A7I2V2V4
A0A7I2YQ81
A0A7I2V675
ENST00000677046.1
ENST00000676733.1
ENST00000677483.1
Q86TM2
B5BUC0
ENST00000676844.1
A0A7I2V5G5
Q6FI27
A0A7I2V5M2
ENST00000678159.1
ENST00000678013.1
ENST00000678064.1
ENST00000679188.1
A0A7I2YQU1
A0A7I2V441
ENST00000677648.1
A0A7I2V2T2
ENST00000678181.1
A0A3B3ITW1
ENST00000316626.6 [P49841-2]
A0A7I2V4W7
A0A7I2V3Z5
A0A7I2YQB0
ENST00000678439.1
ENST00000678678.1
A0A7I2V3A4
A0A7I2YQK0
ENST00000676948.1
ENST00000678286.1
A0A7I2V2K7
ENST00000677069.1
ENST00000678608.1
ENST00000650344.2
A0A7I2V4X2
A0A7I2V3D8
ENST00000679206.1
ENST00000677423.1
A0A7I2YQK2
P49841
A0A7I2V2I5
A0A7I2V2N4
A0A7I2V626
ENST00000677034.1
A0A7I2V5P4
A0A7I2V3T3
ENST00000677338.1
ENST00000677878.1
ENST00000678561.1
ENST00000679194.1