CD70 | OmnibusX

Name	Number of supported studies	Average coverage
regulatory T cell	4 studies	30% ± 14%	Explore
memory B cell	3 studies	25% ± 8%	Explore
CD4-positive, alpha-beta T cell	3 studies	33% ± 12%	Explore
effector CD8-positive, alpha-beta T cell	3 studies	38% ± 17%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of CD70 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
kidney	64%	21.79	57 / 89	80%	74.39	720 / 901
lung	86%	33.47	499 / 578	41%	4.86	475 / 1155
skin	75%	38.26	1357 / 1809	52%	7.64	245 / 472
intestine	69%	34.65	665 / 966	44%	4.92	232 / 527
esophagus	67%	22.79	971 / 1445	45%	5.21	82 / 183
lymph node	0%	0	0 / 0	100%	94.20	29 / 29
spleen	100%	113.87	241 / 241	0%	0	0 / 0
uterus	38%	7.61	65 / 170	55%	14.55	252 / 459
peripheral blood	93%	2969.21	861 / 929	0%	0	0 / 0
thymus	51%	12.43	336 / 653	41%	4.90	246 / 605
stomach	35%	6.89	124 / 359	51%	5.90	145 / 286
breast	56%	18.57	257 / 459	26%	1.28	290 / 1118
adipose	79%	66.58	955 / 1204	0%	0	0 / 0
bladder	43%	8.48	9 / 21	36%	5.25	182 / 504
tonsil	0%	0	0 / 0	76%	11.80	34 / 45
pancreas	5%	0.62	15 / 328	46%	3.90	82 / 178
prostate	34%	4.74	84 / 245	1%	0.04	6 / 502
blood vessel	34%	8.68	458 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	31%	3.24	25 / 80
brain	18%	2.83	463 / 2642	11%	2.14	80 / 705
ovary	4%	0.59	8 / 180	17%	1.73	75 / 430
liver	14%	1.86	31 / 226	5%	0.80	21 / 406
adrenal gland	11%	1.26	28 / 258	2%	1.13	5 / 230
heart	12%	2.35	107 / 861	0%	0	0 / 0
muscle	10%	1.40	77 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0097191	Biological process	extrinsic apoptotic signaling pathway
GO_0042102	Biological process	positive regulation of T cell proliferation
GO_0042100	Biological process	B cell proliferation
GO_0090717	Biological process	adaptive immune memory response involving T cells and B cells
GO_0002456	Biological process	T cell mediated immunity
GO_0019724	Biological process	B cell mediated immunity
GO_0042110	Biological process	T cell activation
GO_0033209	Biological process	tumor necrosis factor-mediated signaling pathway
GO_0160162	Biological process	CD27 signaling pathway
GO_0007166	Biological process	cell surface receptor signaling pathway
GO_0070062	Cellular component	extracellular exosome
GO_0005886	Cellular component	plasma membrane
GO_0005164	Molecular function	tumor necrosis factor receptor binding
GO_0005515	Molecular function	protein binding
GO_0048018	Molecular function	receptor ligand activity

Gene name	CD70
Protein name	CD70 antigen (CD27 ligand) (CD27-L) (Tumor necrosis factor ligand superfamily member 7) (CD antigen CD70) CD70 molecule
Synonyms	CD27LG CD27L TNFSF7
Description	FUNCTION: Cytokine which is the ligand for CD27. The CD70-CD27 pathway plays an important role in the generation and maintenance of T cell immunity, in particular during antiviral responses. Upon CD27 binding, induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells. .
Accessions	ENST00000245903.4 [P32970-1] P32970 ENST00000423145.7 [P32970-2] M0QZW2 ENST00000597430.2

CD70 report