SGPP1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0097191Biological processextrinsic apoptotic signaling pathway
GO_0045616Biological processregulation of keratinocyte differentiation
GO_0097193Biological processintrinsic apoptotic signaling pathway
GO_0006670Biological processsphingosine metabolic process
GO_0030149Biological processsphingolipid catabolic process
GO_0006668Biological processsphinganine-1-phosphate metabolic process
GO_0045682Biological processregulation of epidermis development
GO_0046839Biological processphospholipid dephosphorylation
GO_0035621Biological processER to Golgi ceramide transport
GO_0005886Cellular componentplasma membrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0070780Molecular functiondihydrosphingosine-1-phosphate phosphatase activity
GO_0042392Molecular functionsphingosine-1-phosphate phosphatase activity

IV. Literature review

[source]
Gene nameSGPP1
Protein nameSphingosine-1-phosphate phosphatase 1 (SPPase1) (Spp1) (hSPP1) (hSPPase1) (EC 3.1.3.-) (Sphingosine-1-phosphatase 1) (Sphingosine-1-phosphate phosphohydrolase 1) (SPP-1)
SynonymsSPP1
DescriptionFUNCTION: Specifically dephosphorylates sphingosine 1-phosphate (S1P), dihydro-S1P, and phyto-S1P. Does not act on ceramide 1-phosphate, lysophosphatidic acid or phosphatidic acid . Sphingosine-1-phosphate phosphatase activity is needed for efficient recycling of sphingosine into the sphingolipid synthesis pathway . Regulates the intracellular levels of the bioactive sphingolipid metabolite S1P that regulates diverse biological processes acting both as an extracellular receptor ligand or as an intracellular second messenger . Involved in efficient ceramide synthesis from exogenous sphingoid bases. Converts S1P to sphingosine, which is readily metabolized to ceramide via ceramide synthase. In concert with sphingosine kinase 2 (SphK2), recycles sphingosine into ceramide through a phosphorylation/dephosphorylation cycle (By similarity). Regulates endoplasmic-to-Golgi trafficking of ceramides, resulting in the regulation of ceramide levels in the endoplasmic reticulum, preferentially long-chain ceramide species, and influences the anterograde membrane transport of both ceramide and proteins from the endoplasmic reticulum to the Golgi apparatus . The modulation of intracellular ceramide levels in turn regulates apoptosis (By similarity). Via S1P levels, modulates resting tone, intracellular Ca(2+) and myogenic vasoconstriction in resistance arteries . Also involved in unfolded protein response (UPR) and ER stress-induced autophagy via regulation of intracellular S1P levels . Involved in the regulation of epidermal homeostasis and keratinocyte differentiation (By similarity). .

AccessionsENST00000645915.2
ENST00000247225.7
Q9BX95