RNF41 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0097191Biological processextrinsic apoptotic signaling pathway
GO_0051896Biological processregulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0016567Biological processprotein ubiquitination
GO_0008285Biological processnegative regulation of cell population proliferation
GO_2000377Biological processregulation of reactive oxygen species metabolic process
GO_0000209Biological processprotein polyubiquitination
GO_0045637Biological processregulation of myeloid cell differentiation
GO_0010498Biological processproteasomal protein catabolic process
GO_0051865Biological processprotein autoubiquitination
GO_0045732Biological processpositive regulation of protein catabolic process
GO_1901525Biological processnegative regulation of mitophagy
GO_2000379Biological processpositive regulation of reactive oxygen species metabolic process
GO_0045619Biological processregulation of lymphocyte differentiation
GO_0030336Biological processnegative regulation of cell migration
GO_0006914Biological processautophagy
GO_0043408Biological processregulation of MAPK cascade
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0071782Cellular componentendoplasmic reticulum tubular network
GO_0005829Cellular componentcytosol
GO_0005135Molecular functioninterleukin-3 receptor binding
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0019904Molecular functionprotein domain specific binding
GO_0042802Molecular functionidentical protein binding
GO_0031267Molecular functionsmall GTPase binding
GO_0005128Molecular functionerythropoietin receptor binding
GO_0008270Molecular functionzinc ion binding
GO_0004842Molecular functionubiquitin-protein transferase activity
GO_0005515Molecular functionprotein binding
GO_0030971Molecular functionreceptor tyrosine kinase binding

IV. Literature review

[source]
Gene nameRNF41
Protein nameE3 ubiquitin-protein ligase NRDP1 (RING finger protein 41) (RING-type E3 ubiquitin transferase NRDP1)
RING-type E3 ubiquitin transferase (EC 2.3.2.27)
Ring finger protein 41
E3 ubiquitin-protein ligase NRDP1 (EC 2.3.2.27) (RING finger protein 41) (RING-type E3 ubiquitin transferase NRDP1)
SynonymsNRDP1
SBBI03
FLRF
DescriptionFUNCTION: Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins. Polyubiquitinates MYD88. Negatively regulates MYD88-dependent production of pro-inflammatory cytokines. Can promote TRIF-dependent production of type I interferon and inhibits infection with vesicular stomatitis virus (By similarity). Promotes also activation of TBK1 and IRF3. Involved in the ubiquitination of erythropoietin (EPO) and interleukin-3 (IL-3) receptors. Thus, through maintaining basal levels of cytokine receptors, RNF41 is involved in the control of hematopoietic progenitor cell differentiation into myeloerythroid lineages (By similarity). Contributes to the maintenance of steady-state ERBB3 levels by mediating its growth factor-independent degradation. Involved in the degradation of the inhibitor of apoptosis BIRC6 and thus is an important regulator of cell death by promoting apoptosis. Acts also as a PRKN modifier that accelerates its degradation, resulting in a reduction of PRKN activity, influencing the balance of intracellular redox state. The RNF41-PRKN pathway regulates autophagosome-lysosome fusion during late mitophagy. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control . .

AccessionsENST00000394013.6 [Q9H4P4-2]
ENST00000552244.5
F8VSB6
ENST00000615206.4 [Q9H4P4-1]
Q9H4P4
ENST00000552656.5 [Q9H4P4-1]
F8VSE5
ENST00000551711.5
ENST00000549038.5
ENST00000549119.1
F8VSP7
F8VNZ6
F8VVY2
ENST00000547967.5
ENST00000345093.9 [Q9H4P4-1]