Tissue | GTEx Coverage  | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| lung | 100% | 9153.17 | 576 / 578 | 97% | 50.25 | 1118 / 1155 |
| intestine | 97% | 3495.20 | 933 / 966 | 99% | 68.01 | 520 / 527 |
| breast | 100% | 8804.81 | 459 / 459 | 95% | 39.19 | 1058 / 1118 |
| uterus | 99% | 2990.40 | 168 / 170 | 92% | 40.46 | 422 / 459 |
| thymus | 88% | 2090.60 | 576 / 653 | 98% | 45.80 | 590 / 605 |
| liver | 90% | 3660.93 | 204 / 226 | 94% | 36.44 | 381 / 406 |
| bladder | 95% | 3203.00 | 20 / 21 | 87% | 44.71 | 438 / 504 |
| stomach | 81% | 2170.88 | 289 / 359 | 99% | 67.39 | 284 / 286 |
| prostate | 85% | 2351.11 | 209 / 245 | 82% | 19.97 | 414 / 502 |
| skin | 71% | 1600.41 | 1284 / 1809 | 92% | 53.24 | 434 / 472 |
| esophagus | 75% | 1909.59 | 1077 / 1445 | 87% | 38.04 | 159 / 183 |
| adrenal gland | 88% | 1904.98 | 226 / 258 | 73% | 21.05 | 167 / 230 |
| kidney | 67% | 2010.03 | 60 / 89 | 92% | 56.46 | 832 / 901 |
| ovary | 67% | 1404.97 | 120 / 180 | 75% | 21.30 | 322 / 430 |
| brain | 33% | 817.46 | 867 / 2642 | 95% | 41.50 | 670 / 705 |
| pancreas | 14% | 262.44 | 46 / 328 | 98% | 58.10 | 174 / 178 |
| adipose | 100% | 10582.10 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 200.88 | 29 / 29 |
| peripheral blood | 100% | 50152.74 | 929 / 929 | 0% | 0 | 0 / 0 |
| spleen | 100% | 17318.45 | 241 / 241 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 100% | 32.58 | 1 / 1 |
| tonsil | 0% | 0 | 0 / 0 | 96% | 70.06 | 43 / 45 |
| heart | 89% | 2238.73 | 768 / 861 | 0% | 0 | 0 / 0 |
| blood vessel | 79% | 2541.25 | 1055 / 1335 | 0% | 0 | 0 / 0 |
| muscle | 57% | 1135.33 | 458 / 803 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 48% | 13.93 | 38 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0097191 | Biological process | extrinsic apoptotic signaling pathway |
| GO_0031641 | Biological process | regulation of myelination |
| GO_0006954 | Biological process | inflammatory response |
| GO_0051044 | Biological process | positive regulation of membrane protein ectodomain proteolysis |
| GO_0150077 | Biological process | regulation of neuroinflammatory response |
| GO_0042129 | Biological process | regulation of T cell proliferation |
| GO_0071363 | Biological process | cellular response to growth factor stimulus |
| GO_0150098 | Biological process | glial cell-neuron signaling |
| GO_0150079 | Biological process | negative regulation of neuroinflammatory response |
| GO_0050779 | Biological process | RNA destabilization |
| GO_0006955 | Biological process | immune response |
| GO_0003332 | Biological process | negative regulation of extracellular matrix constituent secretion |
| GO_1902339 | Biological process | positive regulation of apoptotic process involved in morphogenesis |
| GO_0048714 | Biological process | positive regulation of oligodendrocyte differentiation |
| GO_0008630 | Biological process | intrinsic apoptotic signaling pathway in response to DNA damage |
| GO_0003176 | Biological process | aortic valve development |
| GO_0002724 | Biological process | regulation of T cell cytokine production |
| GO_0071222 | Biological process | cellular response to lipopolysaccharide |
| GO_0003177 | Biological process | pulmonary valve development |
| GO_0031643 | Biological process | positive regulation of myelination |
| GO_0002718 | Biological process | regulation of cytokine production involved in immune response |
| GO_0033209 | Biological process | tumor necrosis factor-mediated signaling pathway |
| GO_0010614 | Biological process | negative regulation of cardiac muscle hypertrophy |
| GO_0002947 | Cellular component | tumor necrosis factor receptor superfamily complex |
| GO_0005576 | Cellular component | extracellular region |
| GO_0035579 | Cellular component | specific granule membrane |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0045121 | Cellular component | membrane raft |
| GO_0048471 | Cellular component | perinuclear region of cytoplasm |
| GO_0016020 | Cellular component | membrane |
| GO_0043025 | Cellular component | neuronal cell body |
| GO_0043196 | Cellular component | varicosity |
| GO_0043120 | Molecular function | tumor necrosis factor binding |
| GO_0031625 | Molecular function | ubiquitin protein ligase binding |
| GO_0005031 | Molecular function | tumor necrosis factor receptor activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | TNFRSF1B |
| Protein name | Similar to tumor necrosis factor receptor superfamily, member 1B (TNFRSF1B protein) Tumor necrosis factor receptor superfamily, member 1b (EC 3.4.24.86) Soluble TNFR1B variant 1 (TNF receptor superfamily member 1B) Tumor necrosis factor receptor superfamily member 1B (Tumor necrosis factor receptor 2) (TNF-R2) (Tumor necrosis factor receptor type II) (TNF-RII) (TNFR-II) (p75) (p80 TNF-alpha receptor) (CD antigen CD120b) (Etanercept) [Cleaved into: Tumor necrosis factor receptor superfamily member 1b, membrane form; Tumor necrosis factor-binding protein 2 (TBP-2) (TBPII)] |
| Synonyms | TNFBR TNFR1B TNFR2 |
| Description | FUNCTION: Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity. . |
| Accessions | ENST00000536782.2 B5A977 P20333 A0A0K1RN68 ENST00000376259.7 [P20333-1] Q8IVS6 |
