PDIA3 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	43 studies	54% ± 19%	Explore
endothelial cell	43 studies	50% ± 19%	Explore
fibroblast	42 studies	54% ± 22%	Explore
B cell	38 studies	34% ± 10%	Explore
macrophage	38 studies	45% ± 16%	Explore
CD8-positive, alpha-beta T cell	33 studies	47% ± 16%	Explore
T cell	32 studies	40% ± 15%	Explore
pericyte	31 studies	47% ± 20%	Explore
CD4-positive, alpha-beta T cell	31 studies	42% ± 13%	Explore
conventional dendritic cell	28 studies	57% ± 16%	Explore
dendritic cell	26 studies	49% ± 22%	Explore
smooth muscle cell	26 studies	42% ± 17%	Explore
classical monocyte	25 studies	42% ± 16%	Explore
regulatory T cell	25 studies	40% ± 14%	Explore
epithelial cell	24 studies	49% ± 24%	Explore
mast cell	23 studies	45% ± 18%	Explore
plasma cell	23 studies	52% ± 23%	Explore
non-classical monocyte	23 studies	47% ± 15%	Explore
mature NK T cell	22 studies	47% ± 16%	Explore
plasmacytoid dendritic cell	22 studies	66% ± 15%	Explore
monocyte	21 studies	39% ± 15%	Explore
endothelial cell of lymphatic vessel	21 studies	51% ± 20%	Explore
basal cell	21 studies	49% ± 19%	Explore
memory B cell	20 studies	34% ± 12%	Explore
connective tissue cell	20 studies	57% ± 19%	Explore
naive B cell	19 studies	34% ± 10%	Explore
gamma-delta T cell	18 studies	52% ± 17%	Explore
ciliated cell	17 studies	45% ± 16%	Explore
mucosal invariant T cell	16 studies	50% ± 19%	Explore
CD16-negative, CD56-bright natural killer cell, human	15 studies	58% ± 17%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	66% ± 13%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	15 studies	37% ± 12%	Explore
capillary endothelial cell	15 studies	44% ± 18%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	14 studies	43% ± 14%	Explore
myofibroblast cell	14 studies	58% ± 18%	Explore
myeloid cell	14 studies	48% ± 18%	Explore
CD8-positive, alpha-beta memory T cell	13 studies	49% ± 16%	Explore
effector memory CD8-positive, alpha-beta T cell	12 studies	48% ± 17%	Explore
plasmablast	12 studies	62% ± 21%	Explore
secretory cell	12 studies	58% ± 13%	Explore
endothelial cell of artery	12 studies	51% ± 14%	Explore
goblet cell	12 studies	51% ± 18%	Explore
mesothelial cell	12 studies	55% ± 23%	Explore
vein endothelial cell	12 studies	51% ± 15%	Explore
endothelial cell of vascular tree	12 studies	42% ± 11%	Explore
CD4-positive, alpha-beta memory T cell	11 studies	47% ± 12%	Explore
astrocyte	11 studies	29% ± 12%	Explore
type I pneumocyte	10 studies	43% ± 22%	Explore
type II pneumocyte	10 studies	46% ± 22%	Explore
club cell	10 studies	49% ± 20%	Explore
abnormal cell	10 studies	50% ± 17%	Explore
platelet	9 studies	26% ± 8%	Explore
leukocyte	9 studies	42% ± 15%	Explore
IgG plasma cell	9 studies	30% ± 16%	Explore
microglial cell	9 studies	31% ± 17%	Explore
innate lymphoid cell	8 studies	49% ± 14%	Explore
effector CD8-positive, alpha-beta T cell	8 studies	53% ± 19%	Explore
progenitor cell	8 studies	68% ± 12%	Explore
IgA plasma cell	8 studies	38% ± 16%	Explore
alveolar macrophage	7 studies	41% ± 11%	Explore
respiratory goblet cell	7 studies	53% ± 22%	Explore
epithelial cell of proximal tubule	7 studies	32% ± 18%	Explore
neuron	7 studies	45% ± 16%	Explore
hematopoietic stem cell	7 studies	47% ± 15%	Explore
T follicular helper cell	7 studies	40% ± 11%	Explore
oligodendrocyte	7 studies	25% ± 9%	Explore
oligodendrocyte precursor cell	7 studies	33% ± 13%	Explore
hematopoietic precursor cell	6 studies	62% ± 17%	Explore
ionocyte	6 studies	48% ± 9%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	53% ± 16%	Explore
mononuclear phagocyte	6 studies	50% ± 20%	Explore
GABAergic neuron	6 studies	34% ± 17%	Explore
kidney loop of Henle epithelial cell	6 studies	39% ± 16%	Explore
renal alpha-intercalated cell	6 studies	61% ± 8%	Explore
enterocyte	6 studies	43% ± 16%	Explore
transit amplifying cell	6 studies	41% ± 18%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	50% ± 15%	Explore
CD4-positive helper T cell	5 studies	33% ± 17%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	52% ± 16%	Explore
exhausted T cell	5 studies	55% ± 7%	Explore
lymphocyte	5 studies	44% ± 19%	Explore
precursor B cell	5 studies	48% ± 10%	Explore
pro-B cell	5 studies	37% ± 12%	Explore
T-helper 17 cell	5 studies	49% ± 18%	Explore
group 3 innate lymphoid cell	5 studies	67% ± 8%	Explore
mucus secreting cell	5 studies	49% ± 22%	Explore
glial cell	5 studies	38% ± 22%	Explore
granulocyte	5 studies	45% ± 5%	Explore
erythrocyte	5 studies	40% ± 14%	Explore
central memory CD8-positive, alpha-beta T cell	4 studies	44% ± 20%	Explore
deuterosomal cell	4 studies	24% ± 11%	Explore
duct epithelial cell	4 studies	58% ± 20%	Explore
pancreatic A cell	4 studies	76% ± 3%	Explore
type B pancreatic cell	4 studies	70% ± 14%	Explore
glomerular endothelial cell	4 studies	56% ± 8%	Explore
kidney distal convoluted tubule epithelial cell	4 studies	66% ± 14%	Explore
enteroendocrine cell	4 studies	60% ± 12%	Explore
intestinal crypt stem cell	4 studies	40% ± 13%	Explore
erythroblast	4 studies	41% ± 19%	Explore
megakaryocyte	4 studies	43% ± 17%	Explore
brush cell	4 studies	26% ± 9%	Explore
Schwann cell	4 studies	42% ± 25%	Explore
immature B cell	4 studies	39% ± 13%	Explore
retina horizontal cell	4 studies	35% ± 13%	Explore
retinal pigment epithelial cell	4 studies	43% ± 20%	Explore
adventitial cell	4 studies	70% ± 14%	Explore
inflammatory macrophage	4 studies	31% ± 13%	Explore
acinar cell	4 studies	41% ± 17%	Explore
intermediate monocyte	4 studies	58% ± 15%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	58% ± 12%	Explore
hepatocyte	4 studies	45% ± 19%	Explore
luminal cell of prostate epithelium	4 studies	40% ± 7%	Explore
glutamatergic neuron	4 studies	48% ± 15%	Explore
megakaryocyte-erythroid progenitor cell	4 studies	62% ± 23%	Explore
interneuron	4 studies	36% ± 18%	Explore
CD4-positive, alpha-beta cytotoxic T cell	3 studies	45% ± 12%	Explore
precursor cell	3 studies	77% ± 4%	Explore
pancreatic D cell	3 studies	72% ± 8%	Explore
monocyte-derived dendritic cell	3 studies	52% ± 18%	Explore
podocyte	3 studies	74% ± 15%	Explore
neural crest cell	3 studies	48% ± 5%	Explore
retinal ganglion cell	3 studies	46% ± 15%	Explore
renal principal cell	3 studies	61% ± 11%	Explore
extravillous trophoblast	3 studies	96% ± 1%	Explore
placental villous trophoblast	3 studies	95% ± 2%	Explore
common myeloid progenitor	3 studies	51% ± 16%	Explore
amacrine cell	3 studies	37% ± 17%	Explore
serous secreting cell	3 studies	58% ± 3%	Explore
tissue-resident macrophage	3 studies	52% ± 21%	Explore
intraepithelial lymphocyte	3 studies	47% ± 11%	Explore
Mueller cell	3 studies	33% ± 5%	Explore
germinal center B cell	3 studies	38% ± 9%	Explore
myoepithelial cell	3 studies	60% ± 14%	Explore
endothelial cell of sinusoid	3 studies	40% ± 24%	Explore
IgM plasma cell	3 studies	40% ± 17%	Explore
muscle cell	3 studies	40% ± 21%	Explore
pancreatic ductal cell	3 studies	64% ± 10%	Explore
granulocyte monocyte progenitor cell	3 studies	73% ± 11%	Explore
melanocyte	3 studies	33% ± 12%	Explore
keratinocyte	3 studies	29% ± 5%	Explore
T-helper 1 cell	3 studies	57% ± 6%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	50% ± 17%	Explore
double negative thymocyte	3 studies	69% ± 6%	Explore
double-positive, alpha-beta thymocyte	3 studies	69% ± 5%	Explore
progenitor cell of mammary luminal epithelium	3 studies	41% ± 5%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	18 studies	49% ± 15%	Explore
peripheral blood	18 studies	49% ± 12%	Explore
intestine	12 studies	43% ± 19%	Explore
brain	10 studies	35% ± 14%	Explore
kidney	9 studies	43% ± 16%	Explore
eye	7 studies	31% ± 15%	Explore
bone marrow	6 studies	34% ± 17%	Explore
liver	6 studies	37% ± 12%	Explore
pancreas	5 studies	57% ± 24%	Explore
uterus	5 studies	56% ± 22%	Explore
prostate	5 studies	36% ± 10%	Explore
lymph node	5 studies	43% ± 13%	Explore
placenta	4 studies	70% ± 30%	Explore
adipose	4 studies	28% ± 11%	Explore
breast	4 studies	45% ± 4%	Explore
heart	3 studies	28% ± 8%	Explore
adrenal gland	3 studies	34% ± 13%	Explore
esophagus	3 studies	40% ± 27%	Explore
skin	3 studies	36% ± 4%	Explore
thymus	3 studies	48% ± 17%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
pancreas	100%	13885.92	328 / 328	100%	412.12	178 / 178
prostate	100%	15472.78	245 / 245	100%	798.51	502 / 502
esophagus	100%	11447.74	1444 / 1445	100%	413.37	183 / 183
lung	100%	19838.81	578 / 578	100%	477.13	1154 / 1155
thymus	100%	36253.61	653 / 653	100%	619.62	604 / 605
uterus	100%	15205.36	170 / 170	100%	486.68	458 / 459
ovary	100%	15963.76	180 / 180	100%	378.83	429 / 430
breast	100%	14793.17	459 / 459	100%	533.35	1114 / 1118
stomach	100%	13349.04	359 / 359	99%	399.91	284 / 286
intestine	100%	13495.33	966 / 966	99%	416.95	523 / 527
bladder	100%	13317.86	21 / 21	99%	424.57	500 / 504
liver	99%	19072.19	224 / 226	100%	379.68	406 / 406
kidney	100%	14501.15	89 / 89	99%	321.47	892 / 901
skin	100%	21712.74	1807 / 1809	99%	440.60	467 / 472
adrenal gland	100%	15170.85	258 / 258	97%	335.88	222 / 230
brain	95%	5781.77	2506 / 2642	98%	179.95	689 / 705
adipose	100%	15044.70	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	313.47	29 / 29
spleen	100%	14777.75	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	342.20	45 / 45
ureter	0%	0	0 / 0	100%	242.04	1 / 1
blood vessel	100%	18024.93	1332 / 1335	0%	0	0 / 0
heart	97%	9843.75	833 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	96%	259.60	77 / 80
peripheral blood	91%	9240.03	842 / 929	0%	0	0 / 0
muscle	62%	2548.38	501 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0097191	Biological process	extrinsic apoptotic signaling pathway
GO_2001238	Biological process	positive regulation of extrinsic apoptotic signaling pathway
GO_0098761	Biological process	cellular response to interleukin-7
GO_0070527	Biological process	platelet aggregation
GO_0034976	Biological process	response to endoplasmic reticulum stress
GO_0002250	Biological process	adaptive immune response
GO_0006457	Biological process	protein folding
GO_0002502	Biological process	peptide antigen assembly with MHC class I protein complex
GO_0034975	Biological process	protein folding in endoplasmic reticulum
GO_0005615	Cellular component	extracellular space
GO_0070062	Cellular component	extracellular exosome
GO_0055038	Cellular component	recycling endosome membrane
GO_0005925	Cellular component	focal adhesion
GO_0009986	Cellular component	cell surface
GO_0005788	Cellular component	endoplasmic reticulum lumen
GO_0042824	Cellular component	MHC class I peptide loading complex
GO_0061779	Cellular component	Tapasin-ERp57 complex
GO_0005783	Cellular component	endoplasmic reticulum
GO_0045335	Cellular component	phagocytic vesicle
GO_0042470	Cellular component	melanosome
GO_0005634	Cellular component	nucleus
GO_0015035	Molecular function	protein-disulfide reductase activity
GO_0042802	Molecular function	identical protein binding
GO_0004629	Molecular function	phospholipase C activity
GO_0003723	Molecular function	RNA binding
GO_0015036	Molecular function	disulfide oxidoreductase activity
GO_0003756	Molecular function	protein disulfide isomerase activity
GO_0004197	Molecular function	cysteine-type endopeptidase activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	PDIA3
Protein name	Protein disulfide-isomerase A3 (EC 5.3.4.1) (58 kDa glucose-regulated protein) (58 kDa microsomal protein) (p58) (Disulfide isomerase ER-60) (Endoplasmic reticulum resident protein 57) (ER protein 57) (ERp57) (Endoplasmic reticulum resident protein 60) (ER protein 60) (ERp60) Protein disulfide-isomerase (EC 5.3.4.1) Protein disulfide isomerase family A member 3 Protein disulfide-isomerase A6 (EC 5.3.4.1) Alternative protein PDIA3 Protein disulfide-isomerase A3 (EC 5.3.4.1)
Synonyms	ERP57 HEL-S-269 GRP58 hCG_38001 HEL-S-93n ERP60
Description	FUNCTION: Protein disulfide isomerase that catalyzes the formation, isomerization, and reduction or oxidation of disulfide bonds in client proteins and functions as a protein folding chaperone . Core component of the major histocompatibility complex class I (MHC I) peptide loading complex where it functions as an essential folding chaperone for TAPBP. Through TAPBP, assists the dynamic assembly of the MHC I complex with high affinity antigens in the endoplasmic reticulum. Therefore, plays a crucial role in the presentation of antigens to cytotoxic T cells in adaptive immunity . .
Accessions	ENST00000300289.10 F8WBS6 L8EAE7 ENST00000692341.1 ENST00000688851.1 A0A8I5KW00 A0A8I5KTA1 ENST00000684793.1 ENST00000687794.1 A0A8I5QJM1 P30101 H7BZJ3 A0A8I5KP58 ENST00000686929.1 A0A8I5KNU9 A0A8I5KRV3 ENST00000691893.1 A0A8I5KT88 ENST00000686175.1 A0A8I5QKQ5 ENST00000687211.1 ENST00000691274.1 V9HVY3 ENST00000434494.5 ENST00000446523.5 ENST00000686402.1 ENST00000686314.1 ENST00000693281.1 A0A8I5KS72 A0A8I5KXC9 A0A8I5KYJ6 ENST00000690371.1 ENST00000688652.1 ENST00000692484.1 A0A8I5KTT8 ENST00000688330.1 A0A8I5QJ61 A0A8I5KPY2 ENST00000689152.1 A0A8I5QKT6 A0A8I5KXE2 F8WBW5 A0A8I5KW33 ENST00000455250.2

PDIA3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review