IL33 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of IL33 at tissue level.

III. Associated gene sets

GO_0097191Biological processextrinsic apoptotic signaling pathway
GO_0002826Biological processnegative regulation of T-helper 1 type immune response
GO_0032722Biological processpositive regulation of chemokine production
GO_0150142Biological processpositive regulation of CD86 production
GO_0042092Biological processtype 2 immune response
GO_0120042Biological processnegative regulation of macrophage proliferation
GO_0032755Biological processpositive regulation of interleukin-6 production
GO_0002639Biological processpositive regulation of immunoglobulin production
GO_0002686Biological processnegative regulation of leukocyte migration
GO_0032753Biological processpositive regulation of interleukin-4 production
GO_0045348Biological processpositive regulation of MHC class II biosynthetic process
GO_0051770Biological processpositive regulation of nitric-oxide synthase biosynthetic process
GO_0061518Biological processmicroglial cell proliferation
GO_0071260Biological processcellular response to mechanical stimulus
GO_0030225Biological processmacrophage differentiation
GO_0032436Biological processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO_0051607Biological processdefense response to virus
GO_0010628Biological processpositive regulation of gene expression
GO_0010186Biological processpositive regulation of cellular defense response
GO_0032736Biological processpositive regulation of interleukin-13 production
GO_0038172Biological processinterleukin-33-mediated signaling pathway
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0045345Biological processpositive regulation of MHC class I biosynthetic process
GO_0043032Biological processpositive regulation of macrophage activation
GO_0002638Biological processnegative regulation of immunoglobulin production
GO_0032754Biological processpositive regulation of interleukin-5 production
GO_0048714Biological processpositive regulation of oligodendrocyte differentiation
GO_0006606Biological processprotein import into nucleus
GO_0032689Biological processnegative regulation of type II interferon production
GO_0010467Biological processgene expression
GO_0150078Biological processpositive regulation of neuroinflammatory response
GO_0050729Biological processpositive regulation of inflammatory response
GO_0001819Biological processpositive regulation of cytokine production
GO_0106015Biological processnegative regulation of inflammatory response to wounding
GO_0150145Biological processpositive regulation of CD80 production
GO_0032760Biological processpositive regulation of tumor necrosis factor production
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0002282Biological processmicroglial cell activation involved in immune response
GO_0002830Biological processpositive regulation of type 2 immune response
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0005654Cellular componentnucleoplasm
GO_0005737Cellular componentcytoplasm
GO_0030133Cellular componenttransport vesicle
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0005694Cellular componentchromosome
GO_0005634Cellular componentnucleus
GO_0002112Molecular functioninterleukin-33 receptor binding
GO_0005515Molecular functionprotein binding
GO_0005125Molecular functioncytokine activity

IV. Literature review

[source]
Gene nameIL33
Protein nameInterleukin-33 (IL-33) (Interleukin-1 family member 11) (IL-1F11) (Nuclear factor from high endothelial venules) (NF-HEV) [Cleaved into: Interleukin-33 (95-270); Interleukin-33 (99-270); Interleukin-33 (109-270)]
Alternative protein IL33
Interleukin-33
SynonymsC9orf26
IL1F11
NFHEV
DescriptionFUNCTION: Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells . Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines . Also involved in activation of mast cells, basophils, eosinophils and natural killer cells . Acts as an enhancer of polarization of alternatively activated macrophages . Acts as a chemoattractant for Th2 cells, and may function as an 'alarmin', that amplifies immune responses during tissue injury . Induces rapid UCP2-dependent mitochondrial rewiring that attenuates the generation of reactive oxygen species and preserves the integrity of Krebs cycle required for persistent production of itaconate and subsequent GATA3-dependent differentiation of inflammation-resolving alternatively activated macrophages (By similarity). .; FUNCTION: In quiescent endothelia the uncleaved form is constitutively and abundantly expressed, and acts as a chromatin-associated nuclear factor with transcriptional repressor properties, it may sequester nuclear NF-kappaB/RELA, lowering expression of its targets . This form is rapidely lost upon angiogenic or pro-inflammatory activation . .

AccessionsENST00000456383.3 [O95760-2]
ENST00000611532.4 [O95760-3]
A0A1I9RI50
A0A1I9RI51
ENST00000381434.7 [O95760-1]
L8ECM0
ENST00000682010.1 [O95760-1]
ENST00000417746.6 [O95760-4]
O95760