TLR3 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of TLR3 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TLR3 at tissue level.

III. Associated gene sets

GO_0097191Biological processextrinsic apoptotic signaling pathway
GO_0034343Biological processtype III interferon production
GO_0002224Biological processtoll-like receptor signaling pathway
GO_0007254Biological processJNK cascade
GO_0090594Biological processinflammatory response to wounding
GO_0032722Biological processpositive regulation of chemokine production
GO_1901224Biological processpositive regulation of non-canonical NF-kappaB signal transduction
GO_0034346Biological processpositive regulation of type III interferon production
GO_0071466Biological processcellular response to xenobiotic stimulus
GO_0032728Biological processpositive regulation of interferon-beta production
GO_0071260Biological processcellular response to mechanical stimulus
GO_0001774Biological processmicroglial cell activation
GO_0045766Biological processpositive regulation of angiogenesis
GO_0045087Biological processinnate immune response
GO_0043330Biological processresponse to exogenous dsRNA
GO_0007165Biological processsignal transduction
GO_0051607Biological processdefense response to virus
GO_0010628Biological processpositive regulation of gene expression
GO_0032735Biological processpositive regulation of interleukin-12 production
GO_0034138Biological processtoll-like receptor 3 signaling pathway
GO_0046330Biological processpositive regulation of JNK cascade
GO_0032727Biological processpositive regulation of interferon-alpha production
GO_1900017Biological processpositive regulation of cytokine production involved in inflammatory response
GO_0035458Biological processcellular response to interferon-beta
GO_0043331Biological processresponse to dsRNA
GO_0071346Biological processcellular response to type II interferon
GO_0009597Biological processdetection of virus
GO_0098586Biological processcellular response to virus
GO_0006972Biological processhyperosmotic response
GO_0007252Biological processI-kappaB phosphorylation
GO_0043123Biological processpositive regulation of canonical NF-kappaB signal transduction
GO_0032757Biological processpositive regulation of interleukin-8 production
GO_0002730Biological processregulation of dendritic cell cytokine production
GO_0042742Biological processdefense response to bacterium
GO_0060907Biological processpositive regulation of macrophage cytokine production
GO_0008584Biological processmale gonad development
GO_0097527Biological processnecroptotic signaling pathway
GO_0007250Biological processactivation of NF-kappaB-inducing kinase activity
GO_0032729Biological processpositive regulation of type II interferon production
GO_0050729Biological processpositive regulation of inflammatory response
GO_0071360Biological processcellular response to exogenous dsRNA
GO_0043065Biological processpositive regulation of apoptotic process
GO_0032760Biological processpositive regulation of tumor necrosis factor production
GO_0032755Biological processpositive regulation of interleukin-6 production
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0045671Biological processnegative regulation of osteoclast differentiation
GO_0005615Cellular componentextracellular space
GO_0005886Cellular componentplasma membrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0016020Cellular componentmembrane
GO_0005769Cellular componentearly endosome
GO_0031012Cellular componentextracellular matrix
GO_0009986Cellular componentcell surface
GO_0000139Cellular componentGolgi membrane
GO_0005737Cellular componentcytoplasm
GO_0010008Cellular componentendosome membrane
GO_0005765Cellular componentlysosomal membrane
GO_0036020Cellular componentendolysosome membrane
GO_0038023Molecular functionsignaling receptor activity
GO_0038187Molecular functionpattern recognition receptor activity
GO_0004888Molecular functiontransmembrane signaling receptor activity
GO_0042802Molecular functionidentical protein binding
GO_0003725Molecular functiondouble-stranded RNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTLR3
Protein nameToll-like receptor 3 (CD antigen CD283)
TLR3 protein
Toll like receptor 3
Toll like receptor 3 (Toll-like receptor 3, isoform CRA_b)
SynonymshCG_1787812
DescriptionFUNCTION: Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. Acts via the adapter TRIF/TICAM1, leading to NF-kappa-B activation, IRF3 nuclear translocation, cytokine secretion and the inflammatory response. .

AccessionsENST00000508051.2 [O15455-2]
ENST00000513189.1
A0A8V8TN43
ENST00000698352.1
D6RA51
Q6PCD4
ENST00000698351.1
ENST00000512264.1 [O15455-2]
ENST00000504367.1 [O15455-2]
ENST00000698354.1 [O15455-2]
A0A8V8TLN9
ENST00000296795.8 [O15455-1]
O15455