CIB1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0097191Biological processextrinsic apoptotic signaling pathway
GO_0033630Biological processpositive regulation of cell adhesion mediated by integrin
GO_0001525Biological processangiogenesis
GO_0008285Biological processnegative regulation of cell population proliferation
GO_0002931Biological processresponse to ischemia
GO_0031122Biological processcytoplasmic microtubule organization
GO_0007113Biological processendomitotic cell cycle
GO_0030307Biological processpositive regulation of cell growth
GO_0006302Biological processdouble-strand break repair
GO_0070886Biological processpositive regulation of calcineurin-NFAT signaling cascade
GO_0006974Biological processDNA damage response
GO_0001954Biological processpositive regulation of cell-matrix adhesion
GO_0051301Biological processcell division
GO_0007155Biological processcell adhesion
GO_0001934Biological processpositive regulation of protein phosphorylation
GO_0038163Biological processthrombopoietin-mediated signaling pathway
GO_0071363Biological processcellular response to growth factor stimulus
GO_0007026Biological processnegative regulation of microtubule depolymerization
GO_0043085Biological processpositive regulation of catalytic activity
GO_0051302Biological processregulation of cell division
GO_0051898Biological processnegative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0090050Biological processpositive regulation of cell migration involved in sprouting angiogenesis
GO_0051092Biological processpositive regulation of NF-kappaB transcription factor activity
GO_0071356Biological processcellular response to tumor necrosis factor
GO_0001933Biological processnegative regulation of protein phosphorylation
GO_1903078Biological processpositive regulation of protein localization to plasma membrane
GO_0010977Biological processnegative regulation of neuron projection development
GO_0043066Biological processnegative regulation of apoptotic process
GO_0030335Biological processpositive regulation of cell migration
GO_1990090Biological processcellular response to nerve growth factor stimulus
GO_0042127Biological processregulation of cell population proliferation
GO_0090314Biological processpositive regulation of protein targeting to membrane
GO_0045653Biological processnegative regulation of megakaryocyte differentiation
GO_0006915Biological processapoptotic process
GO_1900026Biological processpositive regulation of substrate adhesion-dependent cell spreading
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0070374Biological processpositive regulation of ERK1 and ERK2 cascade
GO_0071902Biological processpositive regulation of protein serine/threonine kinase activity
GO_0030220Biological processplatelet formation
GO_2000256Biological processpositive regulation of male germ cell proliferation
GO_0007286Biological processspermatid development
GO_0032587Cellular componentruffle membrane
GO_0016324Cellular componentapical plasma membrane
GO_0031982Cellular componentvesicle
GO_0005886Cellular componentplasma membrane
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0016020Cellular componentmembrane
GO_0043204Cellular componentperikaryon
GO_0005813Cellular componentcentrosome
GO_0032433Cellular componentfilopodium tip
GO_0042383Cellular componentsarcolemma
GO_0005654Cellular componentnucleoplasm
GO_0005794Cellular componentGolgi apparatus
GO_0043025Cellular componentneuronal cell body
GO_0043005Cellular componentneuron projection
GO_0005783Cellular componentendoplasmic reticulum
GO_0071944Cellular componentcell periphery
GO_0070062Cellular componentextracellular exosome
GO_0030426Cellular componentgrowth cone
GO_0005737Cellular componentcytoplasm
GO_0030424Cellular componentaxon
GO_0030027Cellular componentlamellipodium
GO_0005634Cellular componentnucleus
GO_0043495Molecular functionprotein-membrane adaptor activity
GO_0030291Molecular functionprotein serine/threonine kinase inhibitor activity
GO_0031267Molecular functionsmall GTPase binding
GO_0000287Molecular functionmagnesium ion binding
GO_0044325Molecular functiontransmembrane transporter binding
GO_0005509Molecular functioncalcium ion binding
GO_0005515Molecular functionprotein binding
GO_0008427Molecular functioncalcium-dependent protein kinase inhibitor activity

IV. Literature review

[source]
Gene nameCIB1
Protein nameCalcium and integrin-binding protein 1 (Calmyrin)
Calcium and integrin-binding protein 1 (CIB) (Calcium- and integrin-binding protein) (CIBP) (Calmyrin) (DNA-PKcs-interacting protein) (Kinase-interacting protein) (KIP) (SNK-interacting protein 2-28) (SIP2-28)
SynonymsCIB
PRKDCIP
KIP
DescriptionFUNCTION: Calcium-binding protein that plays a role in the regulation of numerous cellular processes, such as cell differentiation, cell division, cell proliferation, cell migration, thrombosis, angiogenesis, cardiac hypertrophy and apoptosis. Involved in bone marrow megakaryocyte differentiation by negatively regulating thrombopoietin-mediated signaling pathway. Participates in the endomitotic cell cycle of megakaryocyte, a form of mitosis in which both karyokinesis and cytokinesis are interrupted. Plays a role in integrin signaling by negatively regulating alpha-IIb/beta3 activation in thrombin-stimulated megakaryocytes preventing platelet aggregation. Up-regulates PTK2/FAK1 activity, and is also needed for the recruitment of PTK2/FAK1 to focal adhesions; it thus appears to play an important role in focal adhesion formation. Positively regulates cell migration on fibronectin in a CDC42-dependent manner, the effect being negatively regulated by PAK1. Functions as a negative regulator of stress activated MAP kinase (MAPK) signaling pathways. Down-regulates inositol 1,4,5-trisphosphate receptor-dependent calcium signaling. Involved in sphingosine kinase SPHK1 translocation to the plasma membrane in a N-myristoylation-dependent manner preventing TNF-alpha-induced apoptosis. Regulates serine/threonine-protein kinase PLK3 activity for proper completion of cell division progression. Plays a role in microtubule (MT) dynamics during neuronal development; disrupts the MT depolymerization activity of STMN2 attenuating NGF-induced neurite outgrowth and the MT reorganization at the edge of lamellipodia. Promotes cardiomyocyte hypertrophy via activation of the calcineurin/NFAT signaling pathway. Stimulates calcineurin PPP3R1 activity by mediating its anchoring to the sarcolemma. In ischemia-induced (pathological or adaptive) angiogenesis, stimulates endothelial cell proliferation, migration and microvessel formation by activating the PAK1 and ERK1/ERK2 signaling pathway. Promotes also cancer cell survival and proliferation. May regulate cell cycle and differentiation of spermatogenic germ cells, and/or differentiation of supporting Sertoli cells.; FUNCTION: [Isoform 2]: Plays a regulatory role in angiogenesis and tumor growth by mediating PKD/PRKD2-induced vascular endothelial growth factor A (VEGFA) secretion. .; FUNCTION: (Microbial infection) Involved in keratinocyte-intrinsic immunity to human beta-papillomaviruses (HPVs). .

AccessionsQ99828
A0A3B3ISY8
ENST00000328649.11 [Q99828-1]
ENST00000650306.1
ENST00000612800.1 [Q99828-2]