CTTN report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0097191Biological processextrinsic apoptotic signaling pathway
GO_0048870Biological processcell motility
GO_1901524Biological processregulation of mitophagy
GO_0030838Biological processpositive regulation of actin filament polymerization
GO_0030516Biological processregulation of axon extension
GO_0006898Biological processreceptor-mediated endocytosis
GO_0007165Biological processsignal transduction
GO_0006886Biological processintracellular protein transport
GO_0097581Biological processlamellipodium organization
GO_0048812Biological processneuron projection morphogenesis
GO_0030036Biological processactin cytoskeleton organization
GO_0045987Biological processpositive regulation of smooth muscle contraction
GO_0006930Biological processsubstrate-dependent cell migration, cell extension
GO_0048041Biological processfocal adhesion assembly
GO_0097062Biological processdendritic spine maintenance
GO_2001237Biological processnegative regulation of extrinsic apoptotic signaling pathway
GO_0001726Cellular componentruffle
GO_0005856Cellular componentcytoskeleton
GO_0005886Cellular componentplasma membrane
GO_0043197Cellular componentdendritic spine
GO_0030139Cellular componentendocytic vesicle
GO_0002102Cellular componentpodosome
GO_0005794Cellular componentGolgi apparatus
GO_0005884Cellular componentactin filament
GO_0005925Cellular componentfocal adhesion
GO_1990023Cellular componentmitotic spindle midzone
GO_0030863Cellular componentcortical cytoskeleton
GO_0005783Cellular componentendoplasmic reticulum
GO_0005829Cellular componentcytosol
GO_0005938Cellular componentcell cortex
GO_0030426Cellular componentgrowth cone
GO_0005737Cellular componentcytoplasm
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0005905Cellular componentclathrin-coated pit
GO_0030027Cellular componentlamellipodium
GO_0008076Cellular componentvoltage-gated potassium channel complex
GO_0045296Molecular functioncadherin binding
GO_0005522Molecular functionprofilin binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCTTN
Protein nameSrc substrate cortactin (Amplaxin) (Oncogene EMS1)
Cortactin
SynonymsEMS1
DescriptionFUNCTION: Contributes to the organization of the actin cytoskeleton and cell shape . Plays a role in the formation of lamellipodia and in cell migration. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density (By similarity). Plays a role in focal adhesion assembly and turnover (By similarity). In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement . Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cell membrane . Plays a role in receptor-mediated endocytosis via clathrin-coated pits (By similarity). Required for stabilization of KCNH1 channels at the cell membrane . Plays a role in the invasiveness of cancer cells, and the formation of metastases . .

AccessionsH0YEV2
ENST00000672198.1 [Q14247-3]
ENST00000301843.13 [Q14247-1]
H0YCD9
ENST00000346329.7 [Q14247-3]
ENST00000529736.5
ENST00000671805.1 [Q14247-1]
ENST00000671849.1 [Q14247-2]
ENST00000533931.1
A0A0B6XJY7
ENST00000376561.7 [Q14247-2]
Q14247