Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 39 studies | 26% ± 10% | |
fibroblast | 30 studies | 25% ± 8% | |
smooth muscle cell | 18 studies | 21% ± 5% | |
pericyte | 17 studies | 23% ± 6% | |
endothelial cell of lymphatic vessel | 14 studies | 23% ± 5% | |
ciliated cell | 14 studies | 35% ± 18% | |
epithelial cell | 14 studies | 39% ± 21% | |
basal cell | 13 studies | 35% ± 20% | |
type I pneumocyte | 11 studies | 29% ± 10% | |
astrocyte | 11 studies | 25% ± 12% | |
capillary endothelial cell | 10 studies | 21% ± 4% | |
vein endothelial cell | 10 studies | 24% ± 7% | |
endothelial cell of vascular tree | 10 studies | 22% ± 7% | |
club cell | 9 studies | 25% ± 12% | |
goblet cell | 9 studies | 29% ± 16% | |
secretory cell | 8 studies | 34% ± 16% | |
oligodendrocyte | 8 studies | 34% ± 15% | |
endothelial cell of artery | 8 studies | 23% ± 5% | |
respiratory goblet cell | 7 studies | 31% ± 16% | |
platelet | 7 studies | 39% ± 14% | |
glutamatergic neuron | 7 studies | 37% ± 16% | |
connective tissue cell | 7 studies | 26% ± 6% | |
myofibroblast cell | 7 studies | 25% ± 9% | |
adipocyte | 7 studies | 23% ± 6% | |
mesothelial cell | 6 studies | 35% ± 12% | |
type II pneumocyte | 6 studies | 27% ± 11% | |
neuron | 5 studies | 35% ± 14% | |
cardiac muscle cell | 5 studies | 26% ± 7% | |
GABAergic neuron | 5 studies | 32% ± 17% | |
squamous epithelial cell | 4 studies | 44% ± 22% | |
enterocyte | 4 studies | 18% ± 4% | |
luminal cell of prostate epithelium | 4 studies | 29% ± 7% | |
muscle cell | 4 studies | 26% ± 8% | |
abnormal cell | 4 studies | 27% ± 7% | |
oligodendrocyte precursor cell | 4 studies | 30% ± 7% | |
brush cell | 4 studies | 22% ± 7% | |
interneuron | 4 studies | 38% ± 20% | |
pancreatic A cell | 3 studies | 27% ± 6% | |
retinal ganglion cell | 3 studies | 36% ± 14% | |
luminal hormone-sensing cell of mammary gland | 3 studies | 25% ± 4% | |
pancreatic ductal cell | 3 studies | 51% ± 18% | |
megakaryocyte | 3 studies | 27% ± 10% | |
enteroendocrine cell | 3 studies | 28% ± 12% | |
adventitial cell | 3 studies | 27% ± 7% | |
melanocyte | 3 studies | 30% ± 10% | |
transit amplifying cell | 3 studies | 36% ± 27% | |
keratinocyte | 3 studies | 30% ± 7% |
Name | Number of supported studies | Average coverage | |
---|---|---|---|
brain | 11 studies | 29% ± 12% | |
lung | 9 studies | 28% ± 18% | |
heart | 5 studies | 20% ± 2% | |
intestine | 4 studies | 22% ± 9% | |
pancreas | 3 studies | 30% ± 9% | |
breast | 3 studies | 18% ± 3% | |
adipose | 3 studies | 28% ± 14% | |
skin | 3 studies | 23% ± 0% | |
prostate | 3 studies | 21% ± 4% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
ovary | 100% | 18941.11 | 180 / 180 | 100% | 76.92 | 430 / 430 |
prostate | 100% | 17664.78 | 245 / 245 | 100% | 132.08 | 502 / 502 |
lung | 100% | 12875.49 | 578 / 578 | 100% | 152.26 | 1153 / 1155 |
breast | 100% | 14643.11 | 459 / 459 | 100% | 172.79 | 1116 / 1118 |
skin | 100% | 18473.13 | 1809 / 1809 | 100% | 148.27 | 471 / 472 |
uterus | 100% | 19517.13 | 170 / 170 | 100% | 121.91 | 458 / 459 |
kidney | 100% | 15193.78 | 89 / 89 | 100% | 103.75 | 899 / 901 |
pancreas | 100% | 7126.99 | 327 / 328 | 100% | 161.46 | 178 / 178 |
thymus | 100% | 16152.28 | 653 / 653 | 100% | 146.38 | 602 / 605 |
esophagus | 100% | 15662.07 | 1445 / 1445 | 99% | 170.41 | 182 / 183 |
intestine | 100% | 13884.39 | 966 / 966 | 99% | 120.37 | 524 / 527 |
bladder | 100% | 15139.48 | 21 / 21 | 99% | 171.33 | 500 / 504 |
adrenal gland | 100% | 21587.27 | 258 / 258 | 99% | 74.93 | 228 / 230 |
brain | 99% | 8513.57 | 2625 / 2642 | 100% | 78.61 | 703 / 705 |
stomach | 100% | 11633.20 | 359 / 359 | 99% | 99.09 | 283 / 286 |
liver | 100% | 5384.14 | 226 / 226 | 98% | 66.47 | 399 / 406 |
adipose | 100% | 14610.45 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 17638.38 | 1335 / 1335 | 0% | 0 | 0 / 0 |
spleen | 100% | 8720.95 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 167.30 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 110.03 | 1 / 1 |
heart | 100% | 8986.25 | 858 / 861 | 0% | 0 | 0 / 0 |
muscle | 98% | 6475.08 | 790 / 803 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 98% | 93.39 | 78 / 80 |
lymph node | 0% | 0 | 0 / 0 | 41% | 13.24 | 12 / 29 |
peripheral blood | 7% | 231.53 | 62 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0097191 | Biological process | extrinsic apoptotic signaling pathway |
GO_0048870 | Biological process | cell motility |
GO_1901524 | Biological process | regulation of mitophagy |
GO_0030838 | Biological process | positive regulation of actin filament polymerization |
GO_0030516 | Biological process | regulation of axon extension |
GO_0006898 | Biological process | receptor-mediated endocytosis |
GO_0007165 | Biological process | signal transduction |
GO_0006886 | Biological process | intracellular protein transport |
GO_0097581 | Biological process | lamellipodium organization |
GO_0048812 | Biological process | neuron projection morphogenesis |
GO_0030036 | Biological process | actin cytoskeleton organization |
GO_0045987 | Biological process | positive regulation of smooth muscle contraction |
GO_0006930 | Biological process | substrate-dependent cell migration, cell extension |
GO_0048041 | Biological process | focal adhesion assembly |
GO_0097062 | Biological process | dendritic spine maintenance |
GO_2001237 | Biological process | negative regulation of extrinsic apoptotic signaling pathway |
GO_0001726 | Cellular component | ruffle |
GO_0005856 | Cellular component | cytoskeleton |
GO_0005886 | Cellular component | plasma membrane |
GO_0043197 | Cellular component | dendritic spine |
GO_0030139 | Cellular component | endocytic vesicle |
GO_0002102 | Cellular component | podosome |
GO_0005794 | Cellular component | Golgi apparatus |
GO_0005884 | Cellular component | actin filament |
GO_0005925 | Cellular component | focal adhesion |
GO_1990023 | Cellular component | mitotic spindle midzone |
GO_0030863 | Cellular component | cortical cytoskeleton |
GO_0005783 | Cellular component | endoplasmic reticulum |
GO_0005829 | Cellular component | cytosol |
GO_0005938 | Cellular component | cell cortex |
GO_0030426 | Cellular component | growth cone |
GO_0005737 | Cellular component | cytoplasm |
GO_0043231 | Cellular component | intracellular membrane-bounded organelle |
GO_0005905 | Cellular component | clathrin-coated pit |
GO_0030027 | Cellular component | lamellipodium |
GO_0008076 | Cellular component | voltage-gated potassium channel complex |
GO_0045296 | Molecular function | cadherin binding |
GO_0005522 | Molecular function | profilin binding |
GO_0005515 | Molecular function | protein binding |
Gene name | CTTN |
Protein name | Src substrate cortactin (Amplaxin) (Oncogene EMS1) Cortactin |
Synonyms | EMS1 |
Description | FUNCTION: Contributes to the organization of the actin cytoskeleton and cell shape . Plays a role in the formation of lamellipodia and in cell migration. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density (By similarity). Plays a role in focal adhesion assembly and turnover (By similarity). In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement . Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cell membrane . Plays a role in receptor-mediated endocytosis via clathrin-coated pits (By similarity). Required for stabilization of KCNH1 channels at the cell membrane . Plays a role in the invasiveness of cancer cells, and the formation of metastases . . |
Accessions | H0YEV2 ENST00000672198.1 [Q14247-3] ENST00000301843.13 [Q14247-1] H0YCD9 ENST00000346329.7 [Q14247-3] ENST00000529736.5 ENST00000671805.1 [Q14247-1] ENST00000671849.1 [Q14247-2] ENST00000533931.1 A0A0B6XJY7 ENST00000376561.7 [Q14247-2] Q14247 |