TNFRSF10A report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TNFRSF10A at tissue level.

III. Associated gene sets

GO_0097191Biological processextrinsic apoptotic signaling pathway
GO_0071260Biological processcellular response to mechanical stimulus
GO_0007165Biological processsignal transduction
GO_0008625Biological processextrinsic apoptotic signaling pathway via death domain receptors
GO_0036462Biological processTRAIL-activated apoptotic signaling pathway
GO_0006915Biological processapoptotic process
GO_0007250Biological processactivation of NF-kappaB-inducing kinase activity
GO_0043065Biological processpositive regulation of apoptotic process
GO_0005886Cellular componentplasma membrane
GO_0045121Cellular componentmembrane raft
GO_0005794Cellular componentGolgi apparatus
GO_0009986Cellular componentcell surface
GO_0005829Cellular componentcytosol
GO_0045569Molecular functionTRAIL binding
GO_0038023Molecular functionsignaling receptor activity
GO_0005035Molecular functiondeath receptor activity
GO_0042802Molecular functionidentical protein binding
GO_0002020Molecular functionprotease binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTNFRSF10A
Protein nameTNF receptor superfamily member 10a
Alternative protein TNFRSF10A
Tumor necrosis factor receptor superfamily member 10a
Tumor necrosis factor receptor superfamily member 10A (Death receptor 4) (TNF-related apoptosis-inducing ligand receptor 1) (TRAIL receptor 1) (TRAIL-R1) (CD antigen CD261)
TNF receptor superfamily member 10a (Tumor necrosis factor receptor superfamily member 10a variant 2)
SynonymsTRAILR1
APO2
DR4
DescriptionFUNCTION: Receptor for the cytotoxic ligand TNFSF10/TRAIL . The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis . Promotes the activation of NF-kappa-B . .

FUNCTION: Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. .

AccessionsO00220
ENST00000524158.5
F8U8C0
ENST00000613472.1
ENST00000221132.8
C1K3N4
L8EA63
E5RFH1