FASLG report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of FASLG at tissue level.

III. Associated gene sets

GO_0097191Biological processextrinsic apoptotic signaling pathway
GO_0097190Biological processapoptotic signaling pathway
GO_0006919Biological processactivation of cysteine-type endopeptidase activity involved in apoptotic process
GO_0048388Biological processendosomal lumen acidification
GO_0007165Biological processsignal transduction
GO_0008625Biological processextrinsic apoptotic signaling pathway via death domain receptors
GO_1903514Biological processrelease of sequestered calcium ion into cytosol by endoplasmic reticulum
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0007267Biological processcell-cell signaling
GO_0070231Biological processT cell apoptotic process
GO_0043525Biological processpositive regulation of neuron apoptotic process
GO_0016525Biological processnegative regulation of angiogenesis
GO_0045742Biological processpositive regulation of epidermal growth factor receptor signaling pathway
GO_0043123Biological processpositive regulation of canonical NF-kappaB signal transduction
GO_0046666Biological processretinal cell programmed cell death
GO_0030644Biological processintracellular chloride ion homeostasis
GO_0097527Biological processnecroptotic signaling pathway
GO_0006915Biological processapoptotic process
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0006925Biological processinflammatory cell apoptotic process
GO_1905782Biological processpositive regulation of phosphatidylserine exposure on apoptotic cell surface
GO_0070266Biological processnecroptotic process
GO_0043065Biological processpositive regulation of apoptotic process
GO_0070848Biological processresponse to growth factor
GO_2000353Biological processpositive regulation of endothelial cell apoptotic process
GO_0032496Biological processresponse to lipopolysaccharide
GO_0071346Biological processcellular response to type II interferon
GO_0005615Cellular componentextracellular space
GO_0060205Cellular componentcytoplasmic vesicle lumen
GO_0009897Cellular componentexternal side of plasma membrane
GO_0005576Cellular componentextracellular region
GO_0005886Cellular componentplasma membrane
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0070062Cellular componentextracellular exosome
GO_0043202Cellular componentlysosomal lumen
GO_0005901Cellular componentcaveola
GO_0005634Cellular componentnucleus
GO_0005102Molecular functionsignaling receptor binding
GO_0005123Molecular functiondeath receptor binding
GO_0005164Molecular functiontumor necrosis factor receptor binding
GO_0005515Molecular functionprotein binding
GO_0005125Molecular functioncytokine activity

IV. Literature review

[source]
Gene nameFASLG
Protein nameTumor necrosis factor ligand superfamily member 6 (Apoptosis antigen ligand) (APTL) (CD95 ligand) (CD95-L) (Fas antigen ligand) (Fas ligand) (FasL) (CD antigen CD178) [Cleaved into: Tumor necrosis factor ligand superfamily member 6, membrane form; Tumor necrosis factor ligand superfamily member 6, soluble form (Receptor-binding FasL ectodomain) (Soluble Fas ligand) (sFasL); ADAM10-processed FasL form (APL); FasL intracellular domain (FasL ICD) (SPPL2A-processed FasL form) (SPA)]
Tumor necrosis factor ligand superfamily member 6 (CD95 ligand) (Fas antigen ligand)
SynonymsFASL
CD95L
hCG_37643
APT1LG1
TNFSF6
TNLG1A
DescriptionFUNCTION: Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells . Involved in cytotoxic T-cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development . Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses (By similarity). TNFRSF6/FAS-mediated apoptosis has also a role in the induction of peripheral tolerance (By similarity). Binds to TNFRSF6B/DcR3, a decoy receptor that blocks apoptosis . .; FUNCTION: [Tumor necrosis factor ligand superfamily member 6, soluble form]: Induces FAS-mediated activation of NF-kappa-B, initiating non-apoptotic signaling pathways (By similarity). Can induce apoptosis but does not appear to be essential for this process . .; FUNCTION: [FasL intracellular domain]: Cytoplasmic form induces gene transcription inhibition. .

FUNCTION: Cytoplasmic form induces gene transcription inhibition. .

FUNCTION: Cytoplasmic form induces gene transcription inhibition. .

FUNCTION: Cytoplasmic form induces gene transcription inhibition. .

AccessionsQ0VHD7
A0A0H3VB22
Q53ZZ1
P48023
ENST00000367721.3 [P48023-1]
ENST00000340030.4 [P48023-2]