Biological process

GO:0060553, GO:0060554, GO:0060555

RIPK1-mediated regulated necrosis

A programmed necrotic cell death process which begins when a cell receives a signal (e.g. a ligand binding to a death receptor or to a Toll-like receptor), and proceeds through a series of biochemical events (signaling pathways), characterized by activation of receptor-interacting serine/threonine-protein kinase 1 and/or 3 (RIPK1/3, also called RIP1/3) and by critical dependence on mixed lineage kinase domain-like (MLKL), and which typically lead to common morphological features of necrotic cell death. The process ends when the cell has died. The process is divided into a signaling phase, and an execution phase, which is triggered by the former.

PARP-dependent cell death, activation of necroptosis, activation of necroptosis by extracellular signals, activation of necroptosis in response to extracellular signals, activation of necroptosis of activated-T cells, establishment of necroptosis, establishment of necroptosis of activated-T cells, extracellular signal-induced necroptosis, parthanatos

Examples of this are Birc2 and Birc3 (UniProt symbols Q62210 and O08863) in PMID:21052097.