MLKL report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of MLKL at tissue level.

III. Associated gene sets

GO_0097527Biological processnecroptotic signaling pathway
GO_0051607Biological processdefense response to virus
GO_0070266Biological processnecroptotic process
GO_0070207Biological processprotein homotrimerization
GO_0097528Biological processexecution phase of necroptosis
GO_0007166Biological processcell surface receptor signaling pathway
GO_0030054Cellular componentcell junction
GO_0005829Cellular componentcytosol
GO_0005886Cellular componentplasma membrane
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0044877Molecular functionprotein-containing complex binding
GO_0019901Molecular functionprotein kinase binding
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0005515Molecular functionprotein binding
GO_0004672Molecular functionprotein kinase activity
GO_0005524Molecular functionATP binding

IV. Literature review

[source]
Gene nameMLKL
Protein nameMixed lineage kinase domain-like protein (hMLKL)
Mixed lineage kinase domain like pseudokinase
Synonyms
DescriptionFUNCTION: Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process . Does not have protein kinase activity . Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage . In addition to TNF-induced necroptosis, necroptosis can also take place in the nucleus in response to orthomyxoviruses infection: following activation by ZBP1, MLKL is phosphorylated by RIPK3 in the nucleus, triggering disruption of the nuclear envelope and leakage of cellular DNA into the cytosol.following ZBP1 activation, which senses double-stranded Z-RNA structures, nuclear RIPK3 catalyzes phosphorylation and activation of MLKL, promoting disruption of the nuclear envelope and leakage of cellular DNA into the cytosol (By similarity). Binds to highly phosphorylated inositol phosphates such as inositolhexakisphosphate (InsP6) which is essential for its necroptotic function . .

AccessionsENST00000571303.1
ENST00000573267.1
I3L2T9
Q8NB16
ENST00000308807.12 [Q8NB16-1]
ENST00000576529.1
ENST00000306247.11 [Q8NB16-2]
I3L4A6
I3L4Z5
I3L2U3
ENST00000575686.1