PGAM5 | OmnibusX

sc-RNAseq data

Insufficient scRNA-seq data for expression of PGAM5 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	1791.43	1445 / 1445	100%	44.88	183 / 183
ovary	100%	911.13	180 / 180	100%	39.12	430 / 430
uterus	100%	1248.62	170 / 170	100%	59.82	459 / 459
breast	100%	1349.88	459 / 459	100%	49.11	1116 / 1118
skin	100%	2107.65	1809 / 1809	100%	43.03	471 / 472
stomach	100%	1379.37	359 / 359	100%	58.40	285 / 286
intestine	100%	1573.29	966 / 966	100%	71.31	525 / 527
liver	100%	2007.23	226 / 226	100%	31.11	404 / 406
bladder	100%	1572.95	21 / 21	99%	61.65	501 / 504
brain	99%	1479.73	2626 / 2642	100%	34.59	705 / 705
prostate	100%	1333.47	245 / 245	99%	38.15	498 / 502
thymus	100%	1213.37	652 / 653	99%	28.28	600 / 605
pancreas	100%	1376.40	328 / 328	99%	32.38	176 / 178
lung	99%	1272.33	573 / 578	100%	53.45	1152 / 1155
kidney	100%	1504.45	89 / 89	99%	28.47	889 / 901
adrenal gland	100%	2220.60	258 / 258	95%	28.92	219 / 230
adipose	100%	1281.51	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	58.46	29 / 29
muscle	100%	2533.66	803 / 803	0%	0	0 / 0
spleen	100%	1679.85	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	64.27	45 / 45
ureter	0%	0	0 / 0	100%	37.19	1 / 1
blood vessel	100%	1036.68	1331 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	99%	25.10	79 / 80
heart	98%	1227.82	841 / 861	0%	0	0 / 0
peripheral blood	85%	1326.16	794 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_0070266	Biological process	necroptotic process
GO_0016236	Biological process	macroautophagy
GO_0035970	Biological process	peptidyl-threonine dephosphorylation
GO_0120163	Biological process	negative regulation of cold-induced thermogenesis
GO_0090141	Biological process	positive regulation of mitochondrial fission
GO_0005741	Cellular component	mitochondrial outer membrane
GO_0005743	Cellular component	mitochondrial inner membrane
GO_0005739	Cellular component	mitochondrion
GO_0044877	Molecular function	protein-containing complex binding
GO_0016791	Molecular function	phosphatase activity
GO_0005515	Molecular function	protein binding
GO_0017018	Molecular function	myosin phosphatase activity
GO_0005096	Molecular function	GTPase activator activity
GO_0004722	Molecular function	protein serine/threonine phosphatase activity

Gene name	PGAM5
Protein name	Serine/threonine-protein phosphatase PGAM5, mitochondrial (EC 3.1.3.16) (Bcl-XL-binding protein v68) (Phosphoglycerate mutase family member 5) Serine/threonine-protein phosphatase PGAM5, mitochondrial (EC 3.1.3.16) (Phosphoglycerate mutase family member 5) (Serine/threonine-protein phosphatase Pgam5, mitochondrial)
Synonyms
Description	FUNCTION: Mitochondrial serine/threonine phosphatase that dephosphorylates various substrates and thus plays a role in different biological processes including cellular senescence or mitophagy . Modulates cellular senescence by regulating mitochondrial dynamics. Mechanistically, participates in mitochondrial fission through dephosphorylating DNM1L/DRP1 . Additionally, dephosphorylates MFN2 in a stress-sensitive manner and consequently protects it from ubiquitination and degradation to promote mitochondrial network formation . Regulates mitophagy independent of PARKIN by interacting with and dephosphorylating FUNDC1, which interacts with LC3 . Regulates anti-oxidative response by forming a tertiary complex with KEAP1 and NRF2 . Regulates necroptosis by acting as a RIPK3 target and recruiting the RIPK1-RIPK3-MLKL necrosis 'attack' complex to mitochondria . .
Accessions	ENST00000454808.2 Q96HS1 A0A994J4Y8 F5GXG4 ENST00000543955.5 ENST00000704860.1 ENST00000498926.7 [Q96HS1-1] ENST00000317555.6 [Q96HS1-2]

PGAM5 report