BIRC2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_2000377Biological processregulation of reactive oxygen species metabolic process
GO_1901222Biological processregulation of non-canonical NF-kappaB signal transduction
GO_0000209Biological processprotein polyubiquitination
GO_2000116Biological processregulation of cysteine-type endopeptidase activity
GO_1902523Biological processpositive regulation of protein K63-linked ubiquitination
GO_1902443Biological processnegative regulation of ripoptosome assembly involved in necroptotic process
GO_0007249Biological processcanonical NF-kappaB signal transduction
GO_0060544Biological processregulation of necroptotic process
GO_1902527Biological processpositive regulation of protein monoubiquitination
GO_0050727Biological processregulation of inflammatory response
GO_0045471Biological processresponse to ethanol
GO_0001890Biological processplacenta development
GO_1902524Biological processpositive regulation of protein K48-linked ubiquitination
GO_0045088Biological processregulation of innate immune response
GO_0051591Biological processresponse to cAMP
GO_0039535Biological processregulation of RIG-I signaling pathway
GO_0042981Biological processregulation of apoptotic process
GO_0043066Biological processnegative regulation of apoptotic process
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0060546Biological processnegative regulation of necroptotic process
GO_0045595Biological processregulation of cell differentiation
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0001666Biological processresponse to hypoxia
GO_0042127Biological processregulation of cell population proliferation
GO_0043123Biological processpositive regulation of canonical NF-kappaB signal transduction
GO_0070424Biological processregulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO_0006915Biological processapoptotic process
GO_0031398Biological processpositive regulation of protein ubiquitination
GO_0070266Biological processnecroptotic process
GO_0038061Biological processnon-canonical NF-kappaB signal transduction
GO_0034121Biological processregulation of toll-like receptor signaling pathway
GO_0033209Biological processtumor necrosis factor-mediated signaling pathway
GO_0051726Biological processregulation of cell cycle
GO_0007166Biological processcell surface receptor signaling pathway
GO_0009898Cellular componentcytoplasmic side of plasma membrane
GO_0035631Cellular componentCD40 receptor complex
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0001741Cellular componentXY body
GO_0005634Cellular componentnucleus
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0043027Molecular functioncysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO_0044877Molecular functionprotein-containing complex binding
GO_0016740Molecular functiontransferase activity
GO_0042802Molecular functionidentical protein binding
GO_0098770Molecular functionFBXO family protein binding
GO_0051087Molecular functionprotein-folding chaperone binding
GO_0008270Molecular functionzinc ion binding
GO_0004842Molecular functionubiquitin-protein transferase activity
GO_0003713Molecular functiontranscription coactivator activity
GO_0005515Molecular functionprotein binding
GO_0043130Molecular functionubiquitin binding

IV. Literature review

[source]
Gene nameBIRC2
Protein nameBaculoviral IAP repeat-containing protein 2 (EC 2.3.2.27) (Cellular inhibitor of apoptosis 1) (C-IAP1) (IAP homolog B) (Inhibitor of apoptosis protein 2) (hIAP-2) (hIAP2) (RING finger protein 48) (RING-type E3 ubiquitin transferase BIRC2) (TNFR2-TRAF-signaling complex protein 2)
Baculoviral IAP repeat containing 2
SynonymsRNF48
API1
MIHB
DescriptionFUNCTION: Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling, and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, TRAF2, DIABLO/SMAC, MAP3K14/NIK, MAP3K5/ASK1, IKBKG/NEMO, IKBKE and MXD1/MAD1. Can also function as an E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and inactivation. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. Can stimulate the transcriptional activity of E2F1. Plays a role in the modulation of the cell cycle. .

AccessionsH0YDY3
E9PQZ9
E9PMH5
E9PNM6
ENST00000527465.1
ENST00000528344.1
ENST00000532672.5
ENST00000532832.5
E9PI77
ENST00000533742.5
Q13490
ENST00000530675.5 [Q13490-2]
ENST00000613397.4 [Q13490-1]
ENST00000531259.5
E9PIW1
ENST00000227758.7 [Q13490-1]