RIPK3 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of RIPK3 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of RIPK3 at tissue level.

III. Associated gene sets

GO_0043029Biological processT cell homeostasis
GO_0001914Biological processregulation of T cell mediated cytotoxicity
GO_0097190Biological processapoptotic signaling pathway
GO_0070235Biological processregulation of activation-induced cell death of T cells
GO_0032649Biological processregulation of type II interferon production
GO_0048535Biological processlymph node development
GO_0007165Biological processsignal transduction
GO_0060545Biological processpositive regulation of necroptotic process
GO_0051607Biological processdefense response to virus
GO_2001244Biological processpositive regulation of intrinsic apoptotic signaling pathway
GO_0097528Biological processexecution phase of necroptosis
GO_0002819Biological processregulation of adaptive immune response
GO_0048536Biological processspleen development
GO_0072593Biological processreactive oxygen species metabolic process
GO_2000452Biological processregulation of CD8-positive, alpha-beta cytotoxic T cell extravasation
GO_0033077Biological processT cell differentiation in thymus
GO_0051092Biological processpositive regulation of NF-kappaB transcription factor activity
GO_0032147Biological processactivation of protein kinase activity
GO_1990000Biological processamyloid fibril formation
GO_0010922Biological processpositive regulation of phosphatase activity
GO_0042981Biological processregulation of apoptotic process
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0036211Biological processprotein modification process
GO_2000379Biological processpositive regulation of reactive oxygen species metabolic process
GO_0048538Biological processthymus development
GO_0097300Biological processprogrammed necrotic cell death
GO_0097527Biological processnecroptotic signaling pathway
GO_0070266Biological processnecroptotic process
GO_0038061Biological processnon-canonical NF-kappaB signal transduction
GO_0046777Biological processprotein autophosphorylation
GO_0046006Biological processregulation of activated T cell proliferation
GO_0070301Biological processcellular response to hydrogen peroxide
GO_0032991Cellular componentprotein-containing complex
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0106310Molecular functionprotein serine kinase activity
GO_0044877Molecular functionprotein-containing complex binding
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0042802Molecular functionidentical protein binding
GO_0004672Molecular functionprotein kinase activity
GO_0005524Molecular functionATP binding
GO_0003713Molecular functiontranscription coactivator activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameRIPK3
Protein nameReceptor interacting serine/threonine kinase 3
Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3)
SynonymsRIP3
DescriptionFUNCTION: Serine/threonine-protein kinase that activates necroptosis and apoptosis, two parallel forms of cell death . Necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members, is triggered by RIPK3 following activation by ZBP1 . Activated RIPK3 forms a necrosis-inducing complex and mediates phosphorylation of MLKL, promoting MLKL localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage . In addition to TNF-induced necroptosis, necroptosis can also take place in the nucleus in response to orthomyxoviruses infection: following ZBP1 activation, which senses double-stranded Z-RNA structures, nuclear RIPK3 catalyzes phosphorylation and activation of MLKL, promoting disruption of the nuclear envelope and leakage of cellular DNA into the cytosol (By similarity). Also regulates apoptosis: apoptosis depends on RIPK1, FADD and CASP8, and is independent of MLKL and RIPK3 kinase activity (By similarity). Phosphorylates RIPK1: RIPK1 and RIPK3 undergo reciprocal auto- and trans-phosphorylation . In some cell types, also able to restrict viral replication by promoting cell death-independent responses (By similarity). In response to Zika virus infection in neurons, promotes a cell death-independent pathway that restricts viral replication: together with ZBP1, promotes a death-independent transcriptional program that modifies the cellular metabolism via up-regulation expression of the enzyme ACOD1/IRG1 and production of the metabolite itaconate (By similarity). Itaconate inhibits the activity of succinate dehydrogenase, generating a metabolic state in neurons that suppresses replication of viral genomes (By similarity). RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL . These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production . .; FUNCTION: (Microbial infection) In case of herpes simplex virus 1/HHV-1 infection, forms heteromeric amyloid structures with HHV-1 protein RIR1/ICP6 which may inhibit RIPK3-mediated necroptosis, thereby preventing host cell death pathway and allowing viral evasion. .

AccessionsQ9Y572
ENST00000646516.2 [Q9Y572-1]
ENST00000554756.1 [Q9Y572-3]
ENST00000554569.1
H0YJN5
ENST00000643393.1 [Q9Y572-3]
ENST00000216274.10 [Q9Y572-1]