CYLD report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0045577Biological processregulation of B cell differentiation
GO_0050862Biological processpositive regulation of T cell receptor signaling pathway
GO_2001238Biological processpositive regulation of extrinsic apoptotic signaling pathway
GO_2000493Biological processnegative regulation of interleukin-18-mediated signaling pathway
GO_0045582Biological processpositive regulation of T cell differentiation
GO_0045087Biological processinnate immune response
GO_1901026Biological processripoptosome assembly involved in necroptotic process
GO_0060544Biological processregulation of necroptotic process
GO_0048872Biological processhomeostasis of number of cells
GO_0050727Biological processregulation of inflammatory response
GO_0010803Biological processregulation of tumor necrosis factor-mediated signaling pathway
GO_0090090Biological processnegative regulation of canonical Wnt signaling pathway
GO_1902017Biological processregulation of cilium assembly
GO_0032088Biological processnegative regulation of NF-kappaB transcription factor activity
GO_0032480Biological processnegative regulation of type I interferon production
GO_1901223Biological processnegative regulation of non-canonical NF-kappaB signal transduction
GO_0070536Biological processprotein K63-linked deubiquitination
GO_0050728Biological processnegative regulation of inflammatory response
GO_1990108Biological processprotein linear deubiquitination
GO_0006508Biological processproteolysis
GO_0007346Biological processregulation of mitotic cell cycle
GO_0046329Biological processnegative regulation of JNK cascade
GO_0016579Biological processprotein deubiquitination
GO_2001242Biological processregulation of intrinsic apoptotic signaling pathway
GO_0070507Biological processregulation of microtubule cytoskeleton organization
GO_0070266Biological processnecroptotic process
GO_0016055Biological processWnt signaling pathway
GO_1903829Biological processpositive regulation of protein localization
GO_0043369Biological processCD4-positive or CD8-positive, alpha-beta T cell lineage commitment
GO_1903753Biological processnegative regulation of p38MAPK cascade
GO_0035872Biological processnucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO_0030496Cellular componentmidbody
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0009898Cellular componentcytoplasmic side of plasma membrane
GO_0005813Cellular componentcentrosome
GO_0097542Cellular componentciliary tip
GO_0005829Cellular componentcytosol
GO_0005881Cellular componentcytoplasmic microtubule
GO_0036064Cellular componentciliary basal body
GO_0005819Cellular componentspindle
GO_0004843Molecular functioncysteine-type deubiquitinase activity
GO_0070064Molecular functionproline-rich region binding
GO_0019901Molecular functionprotein kinase binding
GO_0061815Molecular functionMet1-linked polyubiquitin deubiquitinase activity
GO_0008270Molecular functionzinc ion binding
GO_1990380Molecular functionK48-linked deubiquitinase activity
GO_0061578Molecular functionK63-linked deubiquitinase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCYLD
Protein nameUbiquitin carboxyl-terminal hydrolase CYLD (EC 3.4.19.12) (Deubiquitinating enzyme CYLD) (Ubiquitin thioesterase CYLD) (Ubiquitin-specific-processing protease CYLD)
CYLD lysine 63 deubiquitinase
CYLD protein
SynonymsHSPC057
CYLD1
KIAA0849
DescriptionFUNCTION: Deubiquitinase that specifically cleaves 'Lys-63'- and linear 'Met-1'-linked polyubiquitin chains and is involved in NF-kappa-B activation and TNF-alpha-induced necroptosis . Negatively regulates NF-kappa-B activation by deubiquitinating upstream signaling factors . Contributes to the regulation of cell survival, proliferation and differentiation via its effects on NF-kappa-B activation . Negative regulator of Wnt signaling . Inhibits HDAC6 and thereby promotes acetylation of alpha-tubulin and stabilization of microtubules . Plays a role in the regulation of microtubule dynamics, and thereby contributes to the regulation of cell proliferation, cell polarization, cell migration, and angiogenesis . Required for normal cell cycle progress and normal cytokinesis . Inhibits nuclear translocation of NF-kappa-B . Plays a role in the regulation of inflammation and the innate immune response, via its effects on NF-kappa-B activation . Dispensable for the maturation of intrathymic natural killer cells, but required for the continued survival of immature natural killer cells (By similarity). Negatively regulates TNFRSF11A signaling and osteoclastogenesis (By similarity). Involved in the regulation of ciliogenesis, allowing ciliary basal bodies to migrate and dock to the plasma membrane; this process does not depend on NF-kappa-B activation (By similarity). Ability to remove linear ('Met-1'-linked) polyubiquitin chains regulates innate immunity and TNF-alpha-induced necroptosis: recruited to the LUBAC complex via interaction with SPATA2 and restricts linear polyubiquitin formation on target proteins . Regulates innate immunity by restricting linear polyubiquitin formation on RIPK2 in response to NOD2 stimulation . Involved in TNF-alpha-induced necroptosis by removing linear ('Met-1'-linked) polyubiquitin chains from RIPK1, thereby regulating the kinase activity of RIPK1 (By similarity). Negatively regulates intestinal inflammation by removing 'Lys-63' linked polyubiquitin chain of NLRP6, thereby reducing the interaction between NLRP6 and PYCARD/ASC and formation of the NLRP6 inflammasome (By similarity). Removes 'Lys-63' linked polyubiquitin chain of MAP3K7, which inhibits phosphorylation and blocks downstream activation of the JNK-p38 kinase cascades . Removes also 'Lys-63'-linked polyubiquitin chains of MAP3K1 and MA3P3K3, which inhibit their interaction with MAP2K1 and MAP2K2 . .

AccessionsH3BPZ5
ENST00000566024.1
ENST00000568704.2
D6CJC5
D6CJC7
ENST00000311559.13 [Q9NQC7-1]
J3QKR2
ENST00000564634.5
ENST00000427738.8 [Q9NQC7-1]
ENST00000564326.5 [Q9NQC7-2]
ENST00000398568.6 [Q9NQC7-2]
D6CJC6
H3BSW9
D6CJC8
H3BS09
J3KRR7
Q9NQC7
ENST00000566206.5
ENST00000569418.5 [Q9NQC7-2]
I3L117
ENST00000562884.1
ENST00000566679.6