PYGL report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0005977Biological processglycogen metabolic process
GO_0009617Biological processresponse to bacterium
GO_0006015Biological process5-phosphoribose 1-diphosphate biosynthetic process
GO_0005980Biological processglycogen catabolic process
GO_0070266Biological processnecroptotic process
GO_0042593Biological processglucose homeostasis
GO_0005576Cellular componentextracellular region
GO_0070062Cellular componentextracellular exosome
GO_0034774Cellular componentsecretory granule lumen
GO_1904813Cellular componentficolin-1-rich granule lumen
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0008184Molecular functionglycogen phosphorylase activity
GO_0019842Molecular functionvitamin binding
GO_0030170Molecular functionpyridoxal phosphate binding
GO_0102250Molecular functionlinear malto-oligosaccharide phosphorylase activity
GO_0102499Molecular functionSHG alpha-glucan phosphorylase activity
GO_0016208Molecular functionAMP binding
GO_0042802Molecular functionidentical protein binding
GO_0032052Molecular functionbile acid binding
GO_0005524Molecular functionATP binding
GO_0005536Molecular functionD-glucose binding
GO_0002060Molecular functionpurine nucleobase binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePYGL
Protein nameGlycogen phosphorylase, liver form (EC 2.4.1.1)
Alpha-1,4 glucan phosphorylase (EC 2.4.1.1)
Synonyms
DescriptionFUNCTION: Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis. .

FUNCTION: Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis. .

FUNCTION: Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis. .

AccessionsENST00000544180.6 [P06737-2]
ENST00000532462.5
Q6P1L4
P06737
ENST00000216392.8 [P06737-1]
E9PK47