PPIF report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1902445Biological processregulation of mitochondrial membrane permeability involved in programmed necrotic cell death
GO_0002931Biological processresponse to ischemia
GO_0090201Biological processnegative regulation of release of cytochrome c from mitochondria
GO_0032780Biological processnegative regulation of ATP-dependent activity
GO_0010849Biological processregulation of proton-transporting ATPase activity, rotational mechanism
GO_1902686Biological processmitochondrial outer membrane permeabilization involved in programmed cell death
GO_0071277Biological processcellular response to calcium ion
GO_0006457Biological processprotein folding
GO_0008637Biological processapoptotic mitochondrial changes
GO_0090324Biological processnegative regulation of oxidative phosphorylation
GO_0043066Biological processnegative regulation of apoptotic process
GO_0051882Biological processmitochondrial depolarization
GO_0098528Biological processskeletal muscle fiber differentiation
GO_0046902Biological processregulation of mitochondrial membrane permeability
GO_0070266Biological processnecroptotic process
GO_2001243Biological processnegative regulation of intrinsic apoptotic signaling pathway
GO_2000276Biological processnegative regulation of oxidative phosphorylation uncoupler activity
GO_0071243Biological processcellular response to arsenic-containing substance
GO_0070301Biological processcellular response to hydrogen peroxide
GO_0000413Biological processprotein peptidyl-prolyl isomerization
GO_0016020Cellular componentmembrane
GO_0005739Cellular componentmitochondrion
GO_0005753Cellular componentmitochondrial proton-transporting ATP synthase complex
GO_0005757Cellular componentmitochondrial permeability transition pore complex
GO_0005759Cellular componentmitochondrial matrix
GO_0005737Cellular componentcytoplasm
GO_0003755Molecular functionpeptidyl-prolyl cis-trans isomerase activity
GO_0042277Molecular functionpeptide binding
GO_0005515Molecular functionprotein binding
GO_0016018Molecular functioncyclosporin A binding

IV. Literature review

[source]
Gene namePPIF
Protein namePeptidyl-prolyl cis-trans isomerase (PPIase) (EC 5.2.1.8)
Peptidyl-prolyl cis-trans isomerase F, mitochondrial (PPIase F) (EC 5.2.1.8) (Cyclophilin D) (CyP-D) (CypD) (Cyclophilin F) (Mitochondrial cyclophilin) (CyP-M) (Rotamase F)
SynonymsCYP3
DescriptionFUNCTION: PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding . Involved in regulation of the mitochondrial permeability transition pore (mPTP) . It is proposed that its association with the mPTP is masking a binding site for inhibiting inorganic phosphate (Pi) and promotes the open probability of the mPTP leading to apoptosis or necrosis; the requirement of the PPIase activity for this function is debated . In cooperation with mitochondrial p53/TP53 is involved in activating oxidative stress-induced necrosis . Involved in modulation of mitochondrial membrane F(1)F(0) ATP synthase activity and regulation of mitochondrial matrix adenine nucleotide levels (By similarity). Has anti-apoptotic activity independently of mPTP and in cooperation with BCL2 inhibits cytochrome c-dependent apoptosis . .

FUNCTION: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. .

FUNCTION: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. .

AccessionsENST00000448165.1
ENST00000225174.8 [P30405-1]
H0Y548
R4GN99
ENST00000472580.6
P30405