TRPM7 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	20 studies	31% ± 13%	Explore
macrophage	13 studies	35% ± 14%	Explore
astrocyte	11 studies	35% ± 16%	Explore
B cell	10 studies	23% ± 7%	Explore
microglial cell	10 studies	33% ± 12%	Explore
fibroblast	10 studies	33% ± 12%	Explore
oligodendrocyte	10 studies	35% ± 12%	Explore
glutamatergic neuron	9 studies	48% ± 27%	Explore
oligodendrocyte precursor cell	9 studies	33% ± 15%	Explore
adipocyte	9 studies	34% ± 10%	Explore
T cell	8 studies	21% ± 6%	Explore
natural killer cell	8 studies	21% ± 5%	Explore
GABAergic neuron	8 studies	42% ± 23%	Explore
myeloid cell	7 studies	29% ± 11%	Explore
epithelial cell	7 studies	36% ± 14%	Explore
CD8-positive, alpha-beta T cell	7 studies	19% ± 3%	Explore
smooth muscle cell	7 studies	25% ± 8%	Explore
mast cell	6 studies	26% ± 10%	Explore
cardiac muscle cell	6 studies	57% ± 22%	Explore
dendritic cell	6 studies	24% ± 3%	Explore
CD16-negative, CD56-bright natural killer cell, human	5 studies	19% ± 3%	Explore
neuron	5 studies	39% ± 17%	Explore
interneuron	5 studies	48% ± 22%	Explore
mucosal invariant T cell	5 studies	20% ± 3%	Explore
naive B cell	5 studies	18% ± 3%	Explore
ciliated cell	5 studies	22% ± 6%	Explore
endothelial cell of lymphatic vessel	5 studies	34% ± 7%	Explore
pericyte	5 studies	29% ± 9%	Explore
type I pneumocyte	5 studies	27% ± 8%	Explore
type II pneumocyte	5 studies	29% ± 7%	Explore
CD4-positive, alpha-beta T cell	4 studies	21% ± 4%	Explore
effector memory CD8-positive, alpha-beta T cell	4 studies	20% ± 5%	Explore
granule cell	4 studies	28% ± 4%	Explore
kidney distal convoluted tubule epithelial cell	4 studies	63% ± 16%	Explore
retinal pigment epithelial cell	4 studies	61% ± 23%	Explore
mesothelial cell	4 studies	32% ± 12%	Explore
lymphocyte	4 studies	33% ± 12%	Explore
basal cell	4 studies	36% ± 22%	Explore
club cell	4 studies	25% ± 7%	Explore
monocyte	4 studies	30% ± 6%	Explore
CD8-positive, alpha-beta memory T cell	4 studies	17% ± 1%	Explore
plasma cell	3 studies	29% ± 5%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	3 studies	21% ± 5%	Explore
vein endothelial cell	3 studies	29% ± 16%	Explore
amacrine cell	3 studies	23% ± 7%	Explore
glycinergic amacrine cell	3 studies	21% ± 4%	Explore
hepatocyte	3 studies	65% ± 14%	Explore
connective tissue cell	3 studies	23% ± 6%	Explore
alveolar macrophage	3 studies	43% ± 9%	Explore
CD16-positive, CD56-dim natural killer cell, human	3 studies	21% ± 3%	Explore
gamma-delta T cell	3 studies	20% ± 3%	Explore
goblet cell	3 studies	29% ± 15%	Explore
transit amplifying cell	3 studies	39% ± 28%	Explore
regulatory T cell	3 studies	19% ± 3%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	13 studies	40% ± 21%	Explore
lung	6 studies	25% ± 8%	Explore
heart	4 studies	43% ± 10%	Explore
eye	4 studies	29% ± 19%	Explore
liver	4 studies	33% ± 17%	Explore
peripheral blood	3 studies	20% ± 3%	Explore
adipose	3 studies	39% ± 9%	Explore
kidney	3 studies	33% ± 5%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	2882.07	1445 / 1445	100%	18.80	183 / 183
lung	100%	3165.66	578 / 578	99%	12.74	1145 / 1155
breast	100%	3341.83	459 / 459	98%	15.14	1091 / 1118
thymus	100%	3622.71	653 / 653	97%	11.24	585 / 605
intestine	100%	3296.24	966 / 966	97%	10.30	509 / 527
pancreas	99%	1783.45	326 / 328	97%	9.72	172 / 178
prostate	100%	2816.91	245 / 245	96%	11.63	482 / 502
stomach	100%	2383.50	359 / 359	96%	12.21	274 / 286
bladder	100%	3505.00	21 / 21	95%	9.46	478 / 504
kidney	100%	2808.43	89 / 89	95%	11.97	853 / 901
uterus	100%	3947.95	170 / 170	95%	9.77	434 / 459
brain	96%	1705.84	2526 / 2642	97%	7.77	685 / 705
skin	100%	4165.98	1809 / 1809	91%	15.14	429 / 472
ovary	100%	4212.08	180 / 180	90%	6.63	388 / 430
adrenal gland	100%	2736.36	258 / 258	87%	7.43	201 / 230
liver	100%	3098.36	226 / 226	84%	7.66	340 / 406
blood vessel	100%	2945.17	1335 / 1335	0%	0	0 / 0
spleen	100%	3071.42	241 / 241	0%	0	0 / 0
adipose	100%	3589.37	1203 / 1204	0%	0	0 / 0
muscle	100%	1848.85	801 / 803	0%	0	0 / 0
heart	97%	2935.55	836 / 861	0%	0	0 / 0
tonsil	0%	0	0 / 0	91%	11.31	41 / 45
lymph node	0%	0	0 / 0	83%	9.69	24 / 29
eye	0%	0	0 / 0	65%	6.59	52 / 80
peripheral blood	65%	2032.25	603 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0051262	Biological process	protein tetramerization
GO_0070266	Biological process	necroptotic process
GO_0016340	Biological process	calcium-dependent cell-matrix adhesion
GO_0098655	Biological process	monoatomic cation transmembrane transport
GO_0006816	Biological process	calcium ion transport
GO_0055080	Biological process	monoatomic cation homeostasis
GO_0070588	Biological process	calcium ion transmembrane transport
GO_0031032	Biological process	actomyosin structure organization
GO_0001726	Cellular component	ruffle
GO_0005886	Cellular component	plasma membrane
GO_0017022	Molecular function	myosin binding
GO_0004674	Molecular function	protein serine/threonine kinase activity
GO_0003779	Molecular function	actin binding
GO_0005262	Molecular function	calcium channel activity
GO_0046872	Molecular function	metal ion binding
GO_0005524	Molecular function	ATP binding
GO_0106310	Molecular function	protein serine kinase activity

IV. Literature review

[source]

Gene name	TRPM7
Protein name	non-specific serine/threonine protein kinase (EC 2.7.11.1) Transient receptor potential cation channel subfamily M member 7 (EC 2.7.11.1) (Channel-kinase 1) (Long transient receptor potential channel 7) (LTrpC-7) (LTrpC7) Transient receptor potential cation channel subfamily M member 7
Synonyms	hCG_39859 CHAK1 LTRPC7
Description	FUNCTION: Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium . Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. Involved in TNF-induced necroptosis downstream of MLKL by mediating calcium influx. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1). .
Accessions	ENST00000646667.1 H0YLN8 ENST00000560955.5 ENST00000561267.5 H0YNM0 A0A0C4DGL2 Q96QT4 ENST00000560638.1

TRPM7 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review