SPATA2 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SPATA2 at tissue level.

III. Associated gene sets

GO_0060544Biological processregulation of necroptotic process
GO_0070266Biological processnecroptotic process
GO_0070536Biological processprotein K63-linked deubiquitination
GO_0007283Biological processspermatogenesis
GO_0072520Biological processseminiferous tubule development
GO_0050727Biological processregulation of inflammatory response
GO_0010803Biological processregulation of tumor necrosis factor-mediated signaling pathway
GO_1990108Biological processprotein linear deubiquitination
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0001650Cellular componentfibrillar center
GO_0044877Molecular functionprotein-containing complex binding
GO_0030159Molecular functionsignaling receptor complex adaptor activity
GO_0005515Molecular functionprotein binding
GO_1990381Molecular functionubiquitin-specific protease binding

IV. Literature review

[source]
Gene nameSPATA2
Protein nameAlternative protein SPATA2
Spermatogenesis-associated protein 2
SynonymsKIAA0757
PD1
DescriptionFUNCTION: Bridging factor that mediates the recruitment of CYLD to the LUBAC complex, thereby regulating TNF-alpha-induced necroptosis . Acts as a direct binding intermediate that bridges RNF31/HOIP, the catalytic subunit of the LUBAC complex, and the deubiquitinase (CYLD), thereby recruiting CYLD to the TNF-R1 signaling complex (TNF-RSC) . Required to activate the 'Met-1'- (linear) and 'Lys-63'-linked deubiquitinase activities of CYLD . Controls the kinase activity of RIPK1 and TNF-alpha-induced necroptosis by promoting 'Met-1'-linked deubiquitination of RIPK1 by CYLD (By similarity). .

AccessionsENST00000422556.1
L8E7J6
ENST00000289431.10
Q9UM82