NLRP6 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of NLRP6 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of NLRP6 at tissue level.

III. Associated gene sets

GO_0051260Biological processprotein homooligomerization
GO_0009617Biological processresponse to bacterium
GO_0070255Biological processregulation of mucus secretion
GO_0051607Biological processdefense response to virus
GO_0070373Biological processnegative regulation of ERK1 and ERK2 cascade
GO_0070269Biological processpyroptotic inflammatory response
GO_0002862Biological processnegative regulation of inflammatory response to antigenic stimulus
GO_0048874Biological processhost-mediated regulation of intestinal microbiota composition
GO_0002526Biological processacute inflammatory response
GO_0050727Biological processregulation of inflammatory response
GO_0042060Biological processwound healing
GO_0007186Biological processG protein-coupled receptor signaling pathway
GO_0050830Biological processdefense response to Gram-positive bacterium
GO_0010506Biological processregulation of autophagy
GO_0034122Biological processnegative regulation of toll-like receptor signaling pathway
GO_0032689Biological processnegative regulation of type II interferon production
GO_0070266Biological processnecroptotic process
GO_0050729Biological processpositive regulation of inflammatory response
GO_0140739Biological processNLRP6 inflammasome complex assembly
GO_0070946Biological processneutrophil-mediated killing of gram-positive bacterium
GO_2000494Biological processpositive regulation of interleukin-18-mediated signaling pathway
GO_0043124Biological processnegative regulation of canonical NF-kappaB signal transduction
GO_0140374Biological processantiviral innate immune response
GO_0002438Biological processacute inflammatory response to antigenic stimulus
GO_0005886Cellular componentplasma membrane
GO_0005829Cellular componentcytosol
GO_0140738Cellular componentNLRP6 inflammasome complex
GO_0005737Cellular componentcytoplasm
GO_0061702Cellular componentcanonical inflammasome complex
GO_0043228Cellular componentnon-membrane-bounded organelle
GO_0031965Cellular componentnuclear membrane
GO_0038187Molecular functionpattern recognition receptor activity
GO_0042277Molecular functionpeptide binding
GO_0035591Molecular functionsignaling adaptor activity
GO_0140693Molecular functionmolecular condensate scaffold activity
GO_0005000Molecular functionvasopressin receptor activity
GO_0005524Molecular functionATP binding
GO_0001530Molecular functionlipopolysaccharide binding
GO_0070891Molecular functionlipoteichoic acid binding
GO_0003725Molecular functiondouble-stranded RNA binding

IV. Literature review

[source]
Gene nameNLRP6
Protein nameNACHT, LRR and PYD domains-containing protein 6 (Angiotensin II/vasopressin receptor) (PYRIN-containing APAF1-like protein 5)
SynonymsPYPAF5
NALP6
DescriptionFUNCTION: Acts as the sensor component of the NLRP6 inflammasome, which mediates inflammasome activation in response to various pathogen-associated signals, leading to maturation and secretion of IL1B and IL18 . Inflammasomes are supramolecular complexes that assemble in the cytosol in response to pathogens and other damage-associated signals and play critical roles in innate immunity and inflammation . Acts as a recognition receptor (PRR): recognizes and binds specific pathogens and other damage-associated signals, such as lipoteichoic acid (LTA), a cell-wall component of Gram-positive bacteria, or double stranded RNA (dsRNA) . May also recognize and bind lipopolysaccharide (LPS), a major component of the outer membrane of Gram-negative bacteria; however, LPS is probably not a major activator of the NLRP6 inflammasome . Following LTA- or dsRNA-binding, NLRP6 undergoes liquid-liquid phase separation (LLPS), enhancing multivalent interactions, an essential step for the formation of the NLRP6 inflammasome polymeric complex . The NLRP6 inflammasome acts by promoting recruitment of effector pro-inflammatory caspases (CASP1 and/or CASP4) that catalyze maturation and secretion of IL1B and IL18 in the extracellular milieu . The NLRP6 inflammasome plays a central role in the maintenance of epithelial integrity and host defense against microbial infections in the intestine . Required to restrict infection against Gram-positive bacteria by recognizing lipoteichoic acid (LTA), leading to recruitment of CASP4 and CASP1, and subsequent maturation and secretion of IL1B and IL18 . Involved in intestinal antiviral innate immunity together with DHX15: recognizes and binds viral dsRNA to restrict infection by enteric viruses through the interferon pathway and GSDMD-dependent release of IL18 . Required to prevent infection by the apicomplexan parasite Cryptosporidium in enterocytes by promoting GSDMD-dependent release of IL18 (By similarity). The NLRP6 inflammasome may also regulate the gut microbiota composition by acting as a sensor of microbiota-associated metabolites to form a PYCARD/ASC-dependent inflammasome for downstream IL18 release and secretion of antimicrobial peptides (By similarity). Essential for gut mucosal self-renewal and proliferation (By similarity). Regulate mucus secretion in an inflammasome- and autophagy-dependent manner to prevent invasion by enteric bacteria, (By similarity). During systemic bacterial infections, the NLRP6 inflammasome negatively regulates neutrophil recruitment and neutrophil extracellular traps (NETs) formation (By similarity). May promote peripheral nerve recovery following injury via an inflammasome-independent mechanism (By similarity). .

AccessionsENST00000312165.5 [P59044-1]
ENST00000534750.6 [P59044-2]
P59044