RIPK1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0097191Biological processextrinsic apoptotic signaling pathway
GO_1901224Biological processpositive regulation of non-canonical NF-kappaB signal transduction
GO_1903265Biological processpositive regulation of tumor necrosis factor-mediated signaling pathway
GO_2001238Biological processpositive regulation of extrinsic apoptotic signaling pathway
GO_0006954Biological processinflammatory response
GO_0045651Biological processpositive regulation of macrophage differentiation
GO_0000165Biological processMAPK cascade
GO_0046330Biological processpositive regulation of JNK cascade
GO_0060545Biological processpositive regulation of necroptotic process
GO_1901026Biological processripoptosome assembly involved in necroptotic process
GO_0010628Biological processpositive regulation of gene expression
GO_1903800Biological processpositive regulation of miRNA processing
GO_0001934Biological processpositive regulation of protein phosphorylation
GO_0062100Biological processpositive regulation of programmed necrotic cell death
GO_0034612Biological processresponse to tumor necrosis factor
GO_0071363Biological processcellular response to growth factor stimulus
GO_0070231Biological processT cell apoptotic process
GO_0043525Biological processpositive regulation of neuron apoptotic process
GO_0070105Biological processpositive regulation of interleukin-6-mediated signaling pathway
GO_0070926Biological processregulation of ATP:ADP antiporter activity
GO_0070301Biological processcellular response to hydrogen peroxide
GO_0051092Biological processpositive regulation of NF-kappaB transcription factor activity
GO_0071356Biological processcellular response to tumor necrosis factor
GO_1990000Biological processamyloid fibril formation
GO_0035556Biological processintracellular signal transduction
GO_0043066Biological processnegative regulation of apoptotic process
GO_0060546Biological processnegative regulation of necroptotic process
GO_0043068Biological processpositive regulation of programmed cell death
GO_2000379Biological processpositive regulation of reactive oxygen species metabolic process
GO_0043123Biological processpositive regulation of canonical NF-kappaB signal transduction
GO_0097300Biological processprogrammed necrotic cell death
GO_0032757Biological processpositive regulation of interleukin-8 production
GO_0030163Biological processprotein catabolic process
GO_2001237Biological processnegative regulation of extrinsic apoptotic signaling pathway
GO_0097527Biological processnecroptotic signaling pathway
GO_0006915Biological processapoptotic process
GO_2001240Biological processnegative regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO_0050729Biological processpositive regulation of inflammatory response
GO_0036289Biological processpeptidyl-serine autophosphorylation
GO_0070266Biological processnecroptotic process
GO_0046777Biological processprotein autophosphorylation
GO_0006979Biological processresponse to oxidative stress
GO_0043065Biological processpositive regulation of apoptotic process
GO_0032760Biological processpositive regulation of tumor necrosis factor production
GO_1900119Biological processpositive regulation of execution phase of apoptosis
GO_0033209Biological processtumor necrosis factor-mediated signaling pathway
GO_0043124Biological processnegative regulation of canonical NF-kappaB signal transduction
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0097343Biological processripoptosome assembly
GO_0097342Cellular componentripoptosome
GO_0043235Cellular componentreceptor complex
GO_0005886Cellular componentplasma membrane
GO_0005739Cellular componentmitochondrion
GO_0032991Cellular componentprotein-containing complex
GO_0005829Cellular componentcytosol
GO_0010008Cellular componentendosome membrane
GO_0031264Cellular componentdeath-inducing signaling complex
GO_0042803Molecular functionprotein homodimerization activity
GO_0070513Molecular functiondeath domain binding
GO_0106310Molecular functionprotein serine kinase activity
GO_0044877Molecular functionprotein-containing complex binding
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0042802Molecular functionidentical protein binding
GO_0004672Molecular functionprotein kinase activity
GO_0035591Molecular functionsignaling adaptor activity
GO_0004706Molecular functionJUN kinase kinase kinase activity
GO_0005524Molecular functionATP binding
GO_0005123Molecular functiondeath receptor binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameRIPK1
Protein nameReceptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Cell death protein RIP) (Receptor-interacting protein 1) (RIP-1)
Receptor interacting serine/threonine kinase 1
SynonymsRIP1
RIP
DescriptionFUNCTION: Serine-threonine kinase which is a key regulator of TNF-mediated apoptosis, necroptosis and inflammatory pathways . Exhibits kinase activity-dependent functions that regulate cell death and kinase-independent scaffold functions regulating inflammatory signaling and cell survival . Has kinase-independent scaffold functions: upon binding of TNF to TNFR1, RIPK1 is recruited to the TNF-R1 signaling complex (TNF-RSC also known as complex I) where it acts as a scaffold protein promoting cell survival, in part, by activating the canonical NF-kappa-B pathway (By similarity). Kinase activity is essential to regulate necroptosis and apoptosis, two parallel forms of cell death: upon activation of its protein kinase activity, regulates assembly of two death-inducing complexes, namely complex IIa (RIPK1-FADD-CASP8), which drives apoptosis, and the complex IIb (RIPK1-RIPK3-MLKL), which drives necroptosis (By similarity). RIPK1 is required to limit CASP8-dependent TNFR1-induced apoptosis (By similarity). In normal conditions, RIPK1 acts as an inhibitor of RIPK3-dependent necroptosis, a process mediated by RIPK3 component of complex IIb, which catalyzes phosphorylation of MLKL upon induction by ZBP1 . Inhibits RIPK3-mediated necroptosis via FADD-mediated recruitment of CASP8, which cleaves RIPK1 and limits TNF-induced necroptosis . Required to inhibit apoptosis and necroptosis during embryonic development: acts by preventing the interaction of TRADD with FADD thereby limiting aberrant activation of CASP8 (By similarity). In addition to apoptosis and necroptosis, also involved in inflammatory response by promoting transcriptional production of pro-inflammatory cytokines, such as interleukin-6 (IL6) . Phosphorylates RIPK3: RIPK1 and RIPK3 undergo reciprocal auto- and trans-phosphorylation . Phosphorylates DAB2IP at 'Ser-728' in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade . Required for ZBP1-induced NF-kappa-B activation in response to DNA damage (By similarity). .

AccessionsENST00000676591.1
ENST00000678809.1
ENST00000679118.1
A0A7I2V5Y1
ENST00000676618.1
ENST00000677799.1
ENST00000380409.3 [Q13546-2]
ENST00000259808.9 [Q13546-1]
ENST00000676965.1
A0A7I2V404
ENST00000677361.1
Q13546
ENST00000678874.1