Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 17 studies | 28% ± 13% | |
oligodendrocyte | 13 studies | 33% ± 13% | |
glutamatergic neuron | 12 studies | 45% ± 24% | |
oligodendrocyte precursor cell | 11 studies | 35% ± 17% | |
astrocyte | 11 studies | 36% ± 15% | |
GABAergic neuron | 10 studies | 45% ± 23% | |
fibroblast | 9 studies | 22% ± 5% | |
amacrine cell | 8 studies | 32% ± 11% | |
retinal rod cell | 8 studies | 24% ± 7% | |
macrophage | 8 studies | 26% ± 6% | |
pericyte | 8 studies | 21% ± 6% | |
smooth muscle cell | 8 studies | 21% ± 3% | |
neuron | 7 studies | 36% ± 15% | |
interneuron | 7 studies | 49% ± 25% | |
microglial cell | 7 studies | 25% ± 7% | |
retinal ganglion cell | 7 studies | 61% ± 20% | |
endothelial cell of lymphatic vessel | 6 studies | 22% ± 5% | |
myeloid cell | 6 studies | 22% ± 5% | |
epithelial cell | 6 studies | 36% ± 15% | |
retina horizontal cell | 6 studies | 33% ± 10% | |
retinal cone cell | 6 studies | 24% ± 6% | |
adipocyte | 6 studies | 23% ± 5% | |
Mueller cell | 6 studies | 20% ± 4% | |
B cell | 5 studies | 20% ± 2% | |
natural killer cell | 4 studies | 19% ± 2% | |
non-classical monocyte | 4 studies | 27% ± 10% | |
retinal bipolar neuron | 4 studies | 20% ± 3% | |
granule cell | 4 studies | 27% ± 8% | |
cardiac muscle cell | 4 studies | 24% ± 2% | |
ciliated cell | 4 studies | 25% ± 8% | |
OFF-bipolar cell | 4 studies | 32% ± 16% | |
ON-bipolar cell | 4 studies | 32% ± 16% | |
dendritic cell | 4 studies | 36% ± 15% | |
CD4-positive, alpha-beta T cell | 3 studies | 18% ± 2% | |
classical monocyte | 3 studies | 28% ± 9% | |
hematopoietic precursor cell | 3 studies | 34% ± 14% | |
abnormal cell | 3 studies | 26% ± 9% | |
GABAergic interneuron | 3 studies | 36% ± 5% | |
lymphocyte | 3 studies | 25% ± 5% | |
GABAergic amacrine cell | 3 studies | 30% ± 10% | |
glycinergic amacrine cell | 3 studies | 29% ± 6% | |
rod bipolar cell | 3 studies | 23% ± 4% | |
neural progenitor cell | 3 studies | 23% ± 5% | |
myofibroblast cell | 3 studies | 23% ± 2% | |
alveolar macrophage | 3 studies | 22% ± 8% | |
monocyte | 3 studies | 22% ± 2% | |
basal cell | 3 studies | 34% ± 13% | |
transit amplifying cell | 3 studies | 34% ± 21% | |
plasmacytoid dendritic cell | 3 studies | 22% ± 5% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
adrenal gland | 100% | 3474.73 | 258 / 258 | 100% | 43.81 | 230 / 230 |
bladder | 100% | 4993.76 | 21 / 21 | 100% | 38.37 | 504 / 504 |
breast | 100% | 4099.98 | 459 / 459 | 100% | 42.24 | 1118 / 1118 |
esophagus | 100% | 4843.06 | 1445 / 1445 | 100% | 47.12 | 183 / 183 |
lung | 100% | 3819.08 | 578 / 578 | 100% | 36.51 | 1155 / 1155 |
ovary | 100% | 4048.19 | 180 / 180 | 100% | 34.58 | 430 / 430 |
prostate | 100% | 4785.31 | 245 / 245 | 100% | 34.99 | 502 / 502 |
uterus | 100% | 4879.58 | 170 / 170 | 100% | 36.64 | 459 / 459 |
brain | 100% | 7408.52 | 2641 / 2642 | 100% | 47.16 | 705 / 705 |
thymus | 100% | 4035.61 | 653 / 653 | 100% | 26.45 | 603 / 605 |
kidney | 100% | 3486.13 | 89 / 89 | 100% | 29.21 | 898 / 901 |
stomach | 100% | 3094.22 | 359 / 359 | 100% | 32.77 | 285 / 286 |
intestine | 100% | 4498.72 | 966 / 966 | 99% | 31.49 | 522 / 527 |
skin | 100% | 4126.93 | 1806 / 1809 | 97% | 35.49 | 458 / 472 |
pancreas | 95% | 1529.15 | 311 / 328 | 99% | 30.01 | 176 / 178 |
liver | 78% | 1141.22 | 176 / 226 | 91% | 14.85 | 368 / 406 |
adipose | 100% | 4081.62 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 4936.05 | 1335 / 1335 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 27.50 | 29 / 29 |
muscle | 100% | 3906.55 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 3482.81 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 34.01 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 41.02 | 1 / 1 |
heart | 97% | 3706.04 | 837 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 88% | 18.72 | 70 / 80 |
peripheral blood | 51% | 2112.92 | 471 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0090200 | Biological process | positive regulation of release of cytochrome c from mitochondria |
GO_1901524 | Biological process | regulation of mitophagy |
GO_0010468 | Biological process | regulation of gene expression |
GO_0000266 | Biological process | mitochondrial fission |
GO_0010821 | Biological process | regulation of mitochondrion organization |
GO_0070585 | Biological process | protein localization to mitochondrion |
GO_0090141 | Biological process | positive regulation of mitochondrial fission |
GO_0006897 | Biological process | endocytosis |
GO_0090149 | Biological process | mitochondrial membrane fission |
GO_0048312 | Biological process | intracellular distribution of mitochondria |
GO_0007029 | Biological process | endoplasmic reticulum organization |
GO_0061025 | Biological process | membrane fusion |
GO_2001244 | Biological process | positive regulation of intrinsic apoptotic signaling pathway |
GO_0160040 | Biological process | mitocytosis |
GO_0065003 | Biological process | protein-containing complex assembly |
GO_1903578 | Biological process | regulation of ATP metabolic process |
GO_0050714 | Biological process | positive regulation of protein secretion |
GO_0051259 | Biological process | protein complex oligomerization |
GO_0043653 | Biological process | mitochondrial fragmentation involved in apoptotic process |
GO_0007005 | Biological process | mitochondrion organization |
GO_0060047 | Biological process | heart contraction |
GO_0016559 | Biological process | peroxisome fission |
GO_0001836 | Biological process | release of cytochrome c from mitochondria |
GO_0090023 | Biological process | positive regulation of neutrophil chemotaxis |
GO_0070266 | Biological process | necroptotic process |
GO_0043065 | Biological process | positive regulation of apoptotic process |
GO_0048511 | Biological process | rhythmic process |
GO_0006816 | Biological process | calcium ion transport |
GO_1900063 | Biological process | regulation of peroxisome organization |
GO_0005903 | Cellular component | brush border |
GO_0005874 | Cellular component | microtubule |
GO_0048471 | Cellular component | perinuclear region of cytoplasm |
GO_0016020 | Cellular component | membrane |
GO_0005789 | Cellular component | endoplasmic reticulum membrane |
GO_0005739 | Cellular component | mitochondrion |
GO_0030672 | Cellular component | synaptic vesicle membrane |
GO_0032991 | Cellular component | protein-containing complex |
GO_0005794 | Cellular component | Golgi apparatus |
GO_0005777 | Cellular component | peroxisome |
GO_0005783 | Cellular component | endoplasmic reticulum |
GO_0005829 | Cellular component | cytosol |
GO_0099073 | Cellular component | mitochondrion-derived vesicle |
GO_0005737 | Cellular component | cytoplasm |
GO_0043231 | Cellular component | intracellular membrane-bounded organelle |
GO_0005741 | Cellular component | mitochondrial outer membrane |
GO_0005905 | Cellular component | clathrin-coated pit |
GO_0042803 | Molecular function | protein homodimerization activity |
GO_0008289 | Molecular function | lipid binding |
GO_0030742 | Molecular function | GTP-dependent protein binding |
GO_0031625 | Molecular function | ubiquitin protein ligase binding |
GO_0042802 | Molecular function | identical protein binding |
GO_0031267 | Molecular function | small GTPase binding |
GO_0005096 | Molecular function | GTPase activator activity |
GO_0005525 | Molecular function | GTP binding |
GO_0008017 | Molecular function | microtubule binding |
GO_0005515 | Molecular function | protein binding |
GO_0003924 | Molecular function | GTPase activity |
Gene name | DNM1L |
Protein name | Dynamin-1-like protein Dynamin-1-like protein (EC 3.6.5.5) Dynamin 1 like Dynamin 1 like (cDNA FLJ59948, highly similar to Dynamin-1-like protein) Dynamin-1-like protein (EC 3.6.5.5) (Dnm1p/Vps1p-like protein) (DVLP) (Dynamin family member proline-rich carboxyl-terminal domain less) (Dymple) (Dynamin-like protein) (Dynamin-like protein 4) (Dynamin-like protein IV) (HdynIV) (Dynamin-related protein 1) Dynamin 1 like (cDNA FLJ59840, highly similar to Dynamin-1-like protein) |
Synonyms | DRP1 DLP1 hCG_1810949 |
Description | FUNCTION: Functions in mitochondrial and peroxisomal division . Mediates membrane fission through oligomerization into membrane-associated tubular structures that wrap around the scission site to constrict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism . The specific recruitment at scission sites is mediated by membrane receptors like MFF, MIEF1 and MIEF2 for mitochondrial membranes . While the recruitment by the membrane receptors is GTP-dependent, the following hydrolysis of GTP induces the dissociation from the receptors and allows DNM1L filaments to curl into closed rings that are probably sufficient to sever a double membrane . Acts downstream of PINK1 to promote mitochondrial fission in a PRKN-dependent manner . Plays an important role in mitochondrial fission during mitosis . Through its function in mitochondrial division, ensures the survival of at least some types of postmitotic neurons, including Purkinje cells, by suppressing oxidative damage (By similarity). Required for normal brain development, including that of cerebellum . Facilitates developmentally regulated apoptosis during neural tube formation (By similarity). Required for a normal rate of cytochrome c release and caspase activation during apoptosis; this requirement may depend upon the cell type and the physiological apoptotic cues (By similarity). Required for formation of endocytic vesicles . Proposed to regulate synaptic vesicle membrane dynamics through association with BCL2L1 isoform Bcl-X(L) which stimulates its GTPase activity in synaptic vesicles; the function may require its recruitment by MFF to clathrin-containing vesicles . Required for programmed necrosis execution . Rhythmic control of its activity following phosphorylation at Ser-637 is essential for the circadian control of mitochondrial ATP production . .; FUNCTION: [Isoform 1]: Inhibits peroxisomal division when overexpressed. .; FUNCTION: [Isoform 4]: Inhibits peroxisomal division when overexpressed. . |
Accessions | A0A994J696 ENST00000358214.9 [O00429-9] A0A994J6A0 A0A994J3G1 A0A994J3F1 ENST00000551076.6 ENST00000381000.8 [O00429-8] B4DPZ9 A0A8V8TRA9 ENST00000549926.6 ENST00000703360.1 ENST00000703361.1 A0A8V8TQV1 A0A994J3G5 A0A994J3M8 ENST00000703367.1 ENST00000547932.6 ENST00000703368.1 ENST00000703371.1 ENST00000413295.6 ENST00000703370.1 H0YI79 ENST00000703365.1 A0A994J409 A0A994J402 ENST00000551643.6 F8VR28 ENST00000550011.6 F8VZ52 ENST00000703362.1 A0A994J6L3 ENST00000553257.6 [O00429-6] A0A8V8TQT5 ENST00000550154.5 ENST00000551476.6 F8VYL3 F8W1W3 ENST00000266481.10 [O00429-4] F8VUJ9 O00429 ENST00000434676.7 A0A994J6L8 ENST00000546757.6 ENST00000703372.1 ENST00000548750.6 ENST00000703337.1 Q32Q67 A0A994J691 ENST00000703369.1 ENST00000547078.6 H0YHY4 ENST00000548671.6 ENST00000549701.6 [O00429-1] B4DDQ3 ENST00000546649.5 ENST00000547312.5 [O00429-2] ENST00000452533.6 [O00429-3] ENST00000703338.1 |