DNM1L report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0090200Biological processpositive regulation of release of cytochrome c from mitochondria
GO_1901524Biological processregulation of mitophagy
GO_0010468Biological processregulation of gene expression
GO_0000266Biological processmitochondrial fission
GO_0010821Biological processregulation of mitochondrion organization
GO_0070585Biological processprotein localization to mitochondrion
GO_0090141Biological processpositive regulation of mitochondrial fission
GO_0006897Biological processendocytosis
GO_0090149Biological processmitochondrial membrane fission
GO_0048312Biological processintracellular distribution of mitochondria
GO_0007029Biological processendoplasmic reticulum organization
GO_0061025Biological processmembrane fusion
GO_2001244Biological processpositive regulation of intrinsic apoptotic signaling pathway
GO_0160040Biological processmitocytosis
GO_0065003Biological processprotein-containing complex assembly
GO_1903578Biological processregulation of ATP metabolic process
GO_0050714Biological processpositive regulation of protein secretion
GO_0051259Biological processprotein complex oligomerization
GO_0043653Biological processmitochondrial fragmentation involved in apoptotic process
GO_0007005Biological processmitochondrion organization
GO_0060047Biological processheart contraction
GO_0016559Biological processperoxisome fission
GO_0001836Biological processrelease of cytochrome c from mitochondria
GO_0090023Biological processpositive regulation of neutrophil chemotaxis
GO_0070266Biological processnecroptotic process
GO_0043065Biological processpositive regulation of apoptotic process
GO_0048511Biological processrhythmic process
GO_0006816Biological processcalcium ion transport
GO_1900063Biological processregulation of peroxisome organization
GO_0005903Cellular componentbrush border
GO_0005874Cellular componentmicrotubule
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0016020Cellular componentmembrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005739Cellular componentmitochondrion
GO_0030672Cellular componentsynaptic vesicle membrane
GO_0032991Cellular componentprotein-containing complex
GO_0005794Cellular componentGolgi apparatus
GO_0005777Cellular componentperoxisome
GO_0005783Cellular componentendoplasmic reticulum
GO_0005829Cellular componentcytosol
GO_0099073Cellular componentmitochondrion-derived vesicle
GO_0005737Cellular componentcytoplasm
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0005741Cellular componentmitochondrial outer membrane
GO_0005905Cellular componentclathrin-coated pit
GO_0042803Molecular functionprotein homodimerization activity
GO_0008289Molecular functionlipid binding
GO_0030742Molecular functionGTP-dependent protein binding
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0042802Molecular functionidentical protein binding
GO_0031267Molecular functionsmall GTPase binding
GO_0005096Molecular functionGTPase activator activity
GO_0005525Molecular functionGTP binding
GO_0008017Molecular functionmicrotubule binding
GO_0005515Molecular functionprotein binding
GO_0003924Molecular functionGTPase activity

IV. Literature review

[source]
Gene nameDNM1L
Protein nameDynamin-1-like protein
Dynamin-1-like protein (EC 3.6.5.5)
Dynamin 1 like
Dynamin 1 like (cDNA FLJ59948, highly similar to Dynamin-1-like protein)
Dynamin-1-like protein (EC 3.6.5.5) (Dnm1p/Vps1p-like protein) (DVLP) (Dynamin family member proline-rich carboxyl-terminal domain less) (Dymple) (Dynamin-like protein) (Dynamin-like protein 4) (Dynamin-like protein IV) (HdynIV) (Dynamin-related protein 1)
Dynamin 1 like (cDNA FLJ59840, highly similar to Dynamin-1-like protein)
SynonymsDRP1
DLP1
hCG_1810949
DescriptionFUNCTION: Functions in mitochondrial and peroxisomal division . Mediates membrane fission through oligomerization into membrane-associated tubular structures that wrap around the scission site to constrict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism . The specific recruitment at scission sites is mediated by membrane receptors like MFF, MIEF1 and MIEF2 for mitochondrial membranes . While the recruitment by the membrane receptors is GTP-dependent, the following hydrolysis of GTP induces the dissociation from the receptors and allows DNM1L filaments to curl into closed rings that are probably sufficient to sever a double membrane . Acts downstream of PINK1 to promote mitochondrial fission in a PRKN-dependent manner . Plays an important role in mitochondrial fission during mitosis . Through its function in mitochondrial division, ensures the survival of at least some types of postmitotic neurons, including Purkinje cells, by suppressing oxidative damage (By similarity). Required for normal brain development, including that of cerebellum . Facilitates developmentally regulated apoptosis during neural tube formation (By similarity). Required for a normal rate of cytochrome c release and caspase activation during apoptosis; this requirement may depend upon the cell type and the physiological apoptotic cues (By similarity). Required for formation of endocytic vesicles . Proposed to regulate synaptic vesicle membrane dynamics through association with BCL2L1 isoform Bcl-X(L) which stimulates its GTPase activity in synaptic vesicles; the function may require its recruitment by MFF to clathrin-containing vesicles . Required for programmed necrosis execution . Rhythmic control of its activity following phosphorylation at Ser-637 is essential for the circadian control of mitochondrial ATP production . .; FUNCTION: [Isoform 1]: Inhibits peroxisomal division when overexpressed. .; FUNCTION: [Isoform 4]: Inhibits peroxisomal division when overexpressed. .

AccessionsA0A994J696
ENST00000358214.9 [O00429-9]
A0A994J6A0
A0A994J3G1
A0A994J3F1
ENST00000551076.6
ENST00000381000.8 [O00429-8]
B4DPZ9
A0A8V8TRA9
ENST00000549926.6
ENST00000703360.1
ENST00000703361.1
A0A8V8TQV1
A0A994J3G5
A0A994J3M8
ENST00000703367.1
ENST00000547932.6
ENST00000703368.1
ENST00000703371.1
ENST00000413295.6
ENST00000703370.1
H0YI79
ENST00000703365.1
A0A994J409
A0A994J402
ENST00000551643.6
F8VR28
ENST00000550011.6
F8VZ52
ENST00000703362.1
A0A994J6L3
ENST00000553257.6 [O00429-6]
A0A8V8TQT5
ENST00000550154.5
ENST00000551476.6
F8VYL3
F8W1W3
ENST00000266481.10 [O00429-4]
F8VUJ9
O00429
ENST00000434676.7
A0A994J6L8
ENST00000546757.6
ENST00000703372.1
ENST00000548750.6
ENST00000703337.1
Q32Q67
A0A994J691
ENST00000703369.1
ENST00000547078.6
H0YHY4
ENST00000548671.6
ENST00000549701.6 [O00429-1]
B4DDQ3
ENST00000546649.5
ENST00000547312.5 [O00429-2]
ENST00000452533.6 [O00429-3]
ENST00000703338.1