IPMK report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0046488Biological processphosphatidylinositol metabolic process
GO_0032958Biological processinositol phosphate biosynthetic process
GO_0043647Biological processinositol phosphate metabolic process
GO_0070266Biological processnecroptotic process
GO_0032957Biological processinositol trisphosphate metabolic process
GO_0005654Cellular componentnucleoplasm
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0000825Molecular functioninositol tetrakisphosphate 6-kinase activity
GO_0051765Molecular functioninositol tetrakisphosphate kinase activity
GO_0008440Molecular functioninositol-1,4,5-trisphosphate 3-kinase activity
GO_0000824Molecular functioninositol tetrakisphosphate 3-kinase activity
GO_0047326Molecular functioninositol tetrakisphosphate 5-kinase activity
GO_0102732Molecular functionmyo-inositol-1,2,3,4,6-heptakisphosphate 5-kinase activity
GO_0000823Molecular functioninositol-1,4,5-trisphosphate 6-kinase activity
GO_0046872Molecular functionmetal ion binding
GO_0005524Molecular functionATP binding
GO_0097243Molecular functionflavonoid binding
GO_0005515Molecular functionprotein binding
GO_0046934Molecular function1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity

IV. Literature review

[source]
Gene nameIPMK
Protein nameInositol polyphosphate multikinase (EC 2.7.1.140) (EC 2.7.1.151) (EC 2.7.1.153) (Inositol 1,3,4,6-tetrakisphosphate 5-kinase)
SynonymsIMPK
DescriptionFUNCTION: Inositol phosphate kinase with a broad substrate specificity . Phosphorylates inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) first to inositol 1,3,4,5-tetrakisphosphate and then to inositol 1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5) . Phosphorylates inositol 1,3,4,6-tetrakisphosphate (Ins(1,3,4,6)P4) . Phosphorylates inositol 1,4,5,6-tetrakisphosphate (Ins(1,4,5,6)P4) (By similarity). Phosphorylates glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate to glycero-3-phospho-1D-myo-inositol 3,4,5-trisphosphate . Plays an important role in MLKL-mediated necroptosis via its role in the biosynthesis of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6). Binding of these highly phosphorylated inositol phosphates to MLKL mediates the release of an N-terminal auto-inhibitory region, leading to activation of the kinase. Essential for activated phospho-MLKL to oligomerize and localize to the cell membrane during necroptosis . Required for normal embryonic development, probably via its role in the biosynthesis of inositol 1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5) and inositol hexakisphosphate (InsP6) (By similarity). .

AccessionsQ8NFU5
ENST00000373935.4