SMAD3 | OmnibusX

Name	Number of supported studies	Average coverage
endothelial cell	14 studies	26% ± 10%	Explore
fibroblast	14 studies	32% ± 12%	Explore
oligodendrocyte precursor cell	10 studies	32% ± 15%	Explore
basal cell	10 studies	32% ± 19%	Explore
astrocyte	10 studies	28% ± 8%	Explore
microglial cell	9 studies	28% ± 5%	Explore
epithelial cell	9 studies	37% ± 18%	Explore
ciliated cell	9 studies	21% ± 5%	Explore
B cell	8 studies	24% ± 8%	Explore
adipocyte	8 studies	27% ± 8%	Explore
secretory cell	6 studies	32% ± 12%	Explore
club cell	6 studies	19% ± 3%	Explore
pericyte	6 studies	26% ± 15%	Explore
respiratory goblet cell	5 studies	34% ± 10%	Explore
glutamatergic neuron	5 studies	36% ± 19%	Explore
type I pneumocyte	5 studies	31% ± 12%	Explore
smooth muscle cell	5 studies	23% ± 9%	Explore
retinal pigment epithelial cell	4 studies	40% ± 21%	Explore
naive B cell	4 studies	17% ± 1%	Explore
luminal cell of prostate epithelium	4 studies	27% ± 8%	Explore
classical monocyte	3 studies	22% ± 5%	Explore
conventional dendritic cell	3 studies	23% ± 7%	Explore
non-classical monocyte	3 studies	23% ± 6%	Explore
macrophage	3 studies	27% ± 2%	Explore
squamous epithelial cell	3 studies	35% ± 21%	Explore
CD4-positive, alpha-beta T cell	3 studies	24% ± 4%	Explore
effector memory CD8-positive, alpha-beta T cell	3 studies	21% ± 2%	Explore
mesothelial cell	3 studies	23% ± 3%	Explore
endothelial cell of vascular tree	3 studies	21% ± 7%	Explore
cholangiocyte	3 studies	49% ± 24%	Explore
hepatocyte	3 studies	50% ± 25%	Explore
CD8-positive, alpha-beta T cell	3 studies	18% ± 2%	Explore
connective tissue cell	3 studies	30% ± 6%	Explore
adventitial cell	3 studies	26% ± 7%	Explore
monocyte	3 studies	20% ± 3%	Explore
natural killer cell	3 studies	19% ± 4%	Explore
lymphocyte	3 studies	31% ± 5%	Explore
muscle cell	3 studies	27% ± 7%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	5 studies	28% ± 11%	Explore
lung	4 studies	23% ± 4%	Explore
adipose	3 studies	25% ± 1%	Explore
prostate	3 studies	19% ± 2%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	6519.87	1445 / 1445	100%	55.53	183 / 183
thymus	100%	10148.28	653 / 653	99%	42.73	600 / 605
kidney	100%	6582.91	89 / 89	99%	30.85	893 / 901
lung	100%	6473.82	577 / 578	99%	36.67	1146 / 1155
pancreas	100%	3170.57	328 / 328	99%	47.46	176 / 178
stomach	100%	3784.67	359 / 359	98%	25.76	281 / 286
bladder	100%	8418.86	21 / 21	98%	39.48	494 / 504
prostate	100%	7984.56	245 / 245	98%	18.41	491 / 502
uterus	100%	7676.89	170 / 170	98%	42.87	448 / 459
intestine	100%	4970.56	966 / 966	98%	23.21	514 / 527
breast	100%	6991.82	459 / 459	97%	25.76	1082 / 1118
skin	100%	7326.42	1809 / 1809	95%	18.89	447 / 472
ovary	100%	8121.72	180 / 180	92%	16.89	396 / 430
liver	100%	3081.88	226 / 226	88%	19.06	358 / 406
brain	83%	2527.84	2204 / 2642	99%	26.36	699 / 705
adrenal gland	89%	1685.41	229 / 258	57%	7.37	131 / 230
adipose	100%	8758.18	1204 / 1204	0%	0	0 / 0
spleen	100%	4804.14	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	71.31	1 / 1
muscle	100%	8132.32	802 / 803	0%	0	0 / 0
blood vessel	100%	5925.39	1333 / 1335	0%	0	0 / 0
heart	99%	4541.18	849 / 861	0%	0	0 / 0
tonsil	0%	0	0 / 0	98%	45.95	44 / 45
eye	0%	0	0 / 0	94%	14.16	75 / 80
lymph node	0%	0	0 / 0	69%	9.48	20 / 29
peripheral blood	53%	1897.40	496 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0017015	Biological process	regulation of transforming growth factor beta receptor signaling pathway
GO_0007254	Biological process	JNK cascade
GO_0071560	Biological process	cellular response to transforming growth factor beta stimulus
GO_0008283	Biological process	cell population proliferation
GO_0033689	Biological process	negative regulation of osteoblast proliferation
GO_0001947	Biological process	heart looping
GO_0030878	Biological process	thyroid gland development
GO_0023019	Biological process	signal transduction involved in regulation of gene expression
GO_0006955	Biological process	immune response
GO_0060395	Biological process	SMAD protein signal transduction
GO_0050728	Biological process	negative regulation of inflammatory response
GO_0043066	Biological process	negative regulation of apoptotic process
GO_0001707	Biological process	mesoderm formation
GO_0050821	Biological process	protein stabilization
GO_0001666	Biological process	response to hypoxia
GO_1902895	Biological process	positive regulation of miRNA transcription
GO_0048701	Biological process	embryonic cranial skeleton morphogenesis
GO_0048589	Biological process	developmental growth
GO_0050927	Biological process	positive regulation of positive chemotaxis
GO_0070306	Biological process	lens fiber cell differentiation
GO_0032909	Biological process	regulation of transforming growth factor beta2 production
GO_0042110	Biological process	T cell activation
GO_0042177	Biological process	negative regulation of protein catabolic process
GO_0006919	Biological process	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO_0008285	Biological process	negative regulation of cell population proliferation
GO_0001657	Biological process	ureteric bud development
GO_0071333	Biological process	cellular response to glucose stimulus
GO_0061767	Biological process	negative regulation of lung blood pressure
GO_0001701	Biological process	in utero embryonic development
GO_0061045	Biological process	negative regulation of wound healing
GO_0010629	Biological process	negative regulation of gene expression
GO_0006357	Biological process	regulation of transcription by RNA polymerase II
GO_1902894	Biological process	negative regulation of miRNA transcription
GO_0010628	Biological process	positive regulation of gene expression
GO_0042307	Biological process	positive regulation of protein import into nucleus
GO_0045599	Biological process	negative regulation of fat cell differentiation
GO_0045216	Biological process	cell-cell junction organization
GO_0042060	Biological process	wound healing
GO_0032916	Biological process	positive regulation of transforming growth factor beta3 production
GO_1901203	Biological process	positive regulation of extracellular matrix assembly
GO_0030325	Biological process	adrenal gland development
GO_0045429	Biological process	positive regulation of nitric oxide biosynthetic process
GO_0006355	Biological process	regulation of DNA-templated transcription
GO_0048340	Biological process	paraxial mesoderm morphogenesis
GO_0009653	Biological process	anatomical structure morphogenesis
GO_0048617	Biological process	embryonic foregut morphogenesis
GO_0030308	Biological process	negative regulation of cell growth
GO_0097191	Biological process	extrinsic apoptotic signaling pathway
GO_0051091	Biological process	positive regulation of DNA-binding transcription factor activity
GO_0090263	Biological process	positive regulation of canonical Wnt signaling pathway
GO_0051496	Biological process	positive regulation of stress fiber assembly
GO_0032332	Biological process	positive regulation of chondrocyte differentiation
GO_0001889	Biological process	liver development
GO_0050776	Biological process	regulation of immune response
GO_0032731	Biological process	positive regulation of interleukin-1 beta production
GO_0007492	Biological process	endoderm development
GO_0045893	Biological process	positive regulation of DNA-templated transcription
GO_0050678	Biological process	regulation of epithelial cell proliferation
GO_0045668	Biological process	negative regulation of osteoblast differentiation
GO_0051894	Biological process	positive regulation of focal adhesion assembly
GO_0001756	Biological process	somitogenesis
GO_0038092	Biological process	nodal signaling pathway
GO_0016202	Biological process	regulation of striated muscle tissue development
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_1903243	Biological process	negative regulation of cardiac muscle hypertrophy in response to stress
GO_0032924	Biological process	activin receptor signaling pathway
GO_0060039	Biological process	pericardium development
GO_1902893	Biological process	regulation of miRNA transcription
GO_0000122	Biological process	negative regulation of transcription by RNA polymerase II
GO_0002520	Biological process	immune system development
GO_0098586	Biological process	cellular response to virus
GO_0009880	Biological process	embryonic pattern specification
GO_0030335	Biological process	positive regulation of cell migration
GO_0030154	Biological process	cell differentiation
GO_0010718	Biological process	positive regulation of epithelial to mesenchymal transition
GO_0060290	Biological process	transdifferentiation
GO_0002076	Biological process	osteoblast development
GO_0007179	Biological process	transforming growth factor beta receptor signaling pathway
GO_0030501	Biological process	positive regulation of bone mineralization
GO_1990776	Biological process	response to angiotensin
GO_0051481	Biological process	negative regulation of cytosolic calcium ion concentration
GO_0031053	Biological process	primary miRNA processing
GO_0005634	Cellular component	nucleus
GO_0071141	Cellular component	SMAD protein complex
GO_0005654	Cellular component	nucleoplasm
GO_0043235	Cellular component	receptor complex
GO_0005886	Cellular component	plasma membrane
GO_0005737	Cellular component	cytoplasm
GO_0000785	Cellular component	chromatin
GO_0005667	Cellular component	transcription regulator complex
GO_0005637	Cellular component	nuclear inner membrane
GO_0005829	Cellular component	cytosol
GO_0071144	Cellular component	heteromeric SMAD protein complex
GO_0140297	Molecular function	DNA-binding transcription factor binding
GO_0001228	Molecular function	DNA-binding transcription activator activity, RNA polymerase II-specific
GO_0001222	Molecular function	transcription corepressor binding
GO_0031625	Molecular function	ubiquitin protein ligase binding
GO_0042802	Molecular function	identical protein binding
GO_0001223	Molecular function	transcription coactivator binding
GO_0008270	Molecular function	zinc ion binding
GO_0031490	Molecular function	chromatin DNA binding
GO_0000978	Molecular function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_1990841	Molecular function	promoter-specific chromatin binding
GO_0043565	Molecular function	sequence-specific DNA binding
GO_0061629	Molecular function	RNA polymerase II-specific DNA-binding transcription factor binding
GO_0070410	Molecular function	co-SMAD binding
GO_0019902	Molecular function	phosphatase binding
GO_0017151	Molecular function	DEAD/H-box RNA helicase binding
GO_0001217	Molecular function	DNA-binding transcription repressor activity
GO_0005518	Molecular function	collagen binding
GO_0043130	Molecular function	ubiquitin binding
GO_0035259	Molecular function	nuclear glucocorticoid receptor binding
GO_0000987	Molecular function	cis-regulatory region sequence-specific DNA binding
GO_0000976	Molecular function	transcription cis-regulatory region binding
GO_0003700	Molecular function	DNA-binding transcription factor activity
GO_0005515	Molecular function	protein binding
GO_0003677	Molecular function	DNA binding
GO_0042803	Molecular function	protein homodimerization activity
GO_0070412	Molecular function	R-SMAD binding
GO_0016922	Molecular function	nuclear receptor binding
GO_0043425	Molecular function	bHLH transcription factor binding
GO_0000981	Molecular function	DNA-binding transcription factor activity, RNA polymerase II-specific
GO_0031962	Molecular function	nuclear mineralocorticoid receptor binding
GO_0019901	Molecular function	protein kinase binding
GO_0008013	Molecular function	beta-catenin binding
GO_0032810	Molecular function	sterol response element binding
GO_0070411	Molecular function	I-SMAD binding
GO_0005160	Molecular function	transforming growth factor beta receptor binding

IV. Literature review

[source]

Gene name	SMAD3
Protein name	Mothers against decapentaplegic homolog (MAD homolog) (Mothers against DPP homolog) (SMAD family member) SMAD family member 3 Mothers against decapentaplegic homolog 3 (MAD homolog 3) (Mad3) (Mothers against DPP homolog 3) (hMAD-3) (JV15-2) (SMAD family member 3) (SMAD 3) (Smad3) (hSMAD3)
Synonyms	MADH3
Description	FUNCTION: Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. .
Accessions	ENST00000540846.6 [P84022-3] ENST00000537194.6 [P84022-4] ENST00000558739.1 ENST00000681239.1 [P84022-3] ENST00000558739.2 [P84022-3] H3BVD1 ENST00000558894.5 H0YKE2 ENST00000679624.1 [P84022-3] ENST00000558428.5 ENST00000560424.2 H0YNV1 ENST00000558827.2 [P84022-4] H0YMP2 ENST00000558827.1 P84022 ENST00000559460.6 [P84022-3] H3BQ00 ENST00000559092.1 ENST00000559460.5 ENST00000560175.5 H3BP09 H0YMY0 ENST00000327367.9 [P84022-1] ENST00000439724.7 [P84022-2] H0YL71 ENST00000558428.6 [P84022-4]

SMAD3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review