Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| astrocyte | 17 studies | 33% ± 15% | |
| Mueller cell | 5 studies | 26% ± 4% | |
| endothelial cell of lymphatic vessel | 3 studies | 20% ± 1% | |
| epithelial cell | 3 studies | 20% ± 3% | |
| type I pneumocyte | 3 studies | 27% ± 7% | |
| GABAergic neuron | 3 studies | 30% ± 7% | |
| glutamatergic neuron | 3 studies | 19% ± 2% | |
| ependymal cell | 3 studies | 34% ± 14% |
Insufficient scRNA-seq data for expression of TGFB2 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| prostate | 99% | 1128.60 | 243 / 245 | 92% | 9.99 | 460 / 502 |
| brain | 93% | 574.88 | 2468 / 2642 | 89% | 22.21 | 627 / 705 |
| thymus | 98% | 416.32 | 640 / 653 | 75% | 7.61 | 456 / 605 |
| ovary | 99% | 619.98 | 179 / 180 | 73% | 9.06 | 315 / 430 |
| lung | 100% | 771.39 | 576 / 578 | 73% | 7.16 | 841 / 1155 |
| breast | 87% | 567.61 | 398 / 459 | 80% | 12.91 | 893 / 1118 |
| uterus | 99% | 681.51 | 168 / 170 | 57% | 7.12 | 261 / 459 |
| pancreas | 69% | 198.37 | 226 / 328 | 83% | 11.68 | 147 / 178 |
| esophagus | 72% | 237.44 | 1037 / 1445 | 70% | 6.03 | 129 / 183 |
| bladder | 100% | 407.00 | 21 / 21 | 31% | 2.79 | 158 / 504 |
| stomach | 74% | 214.37 | 266 / 359 | 50% | 3.03 | 142 / 286 |
| skin | 85% | 255.99 | 1531 / 1809 | 33% | 3.80 | 158 / 472 |
| kidney | 56% | 125.10 | 50 / 89 | 52% | 3.33 | 472 / 901 |
| intestine | 72% | 346.34 | 691 / 966 | 33% | 2.38 | 176 / 527 |
| blood vessel | 99% | 825.84 | 1328 / 1335 | 0% | 0 | 0 / 0 |
| adipose | 86% | 290.27 | 1040 / 1204 | 0% | 0 | 0 / 0 |
| muscle | 80% | 433.91 | 639 / 803 | 0% | 0 | 0 / 0 |
| adrenal gland | 50% | 81.16 | 130 / 258 | 25% | 1.04 | 57 / 230 |
| heart | 74% | 280.46 | 641 / 861 | 0% | 0 | 0 / 0 |
| spleen | 66% | 114.46 | 159 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 60% | 3.44 | 27 / 45 |
| liver | 8% | 15.98 | 17 / 226 | 28% | 3.87 | 112 / 406 |
| eye | 0% | 0 | 0 / 0 | 8% | 0.36 | 6 / 80 |
| lymph node | 0% | 0 | 0 / 0 | 3% | 0.08 | 1 / 29 |
| peripheral blood | 1% | 1.43 | 5 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0035910 | Biological process | ascending aorta morphogenesis |
| GO_1903701 | Biological process | substantia propria of cornea development |
| GO_0042476 | Biological process | odontogenesis |
| GO_0048103 | Biological process | somatic stem cell division |
| GO_0048566 | Biological process | embryonic digestive tract development |
| GO_0051795 | Biological process | positive regulation of timing of catagen |
| GO_0003149 | Biological process | membranous septum morphogenesis |
| GO_0009792 | Biological process | embryo development ending in birth or egg hatching |
| GO_0003203 | Biological process | endocardial cushion morphogenesis |
| GO_0042416 | Biological process | dopamine biosynthetic process |
| GO_0001666 | Biological process | response to hypoxia |
| GO_1902895 | Biological process | positive regulation of miRNA transcription |
| GO_0001501 | Biological process | skeletal system development |
| GO_0051897 | Biological process | positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction |
| GO_0000902 | Biological process | cell morphogenesis |
| GO_0032909 | Biological process | regulation of transforming growth factor beta2 production |
| GO_1905007 | Biological process | positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation |
| GO_1904888 | Biological process | cranial skeletal system development |
| GO_0051781 | Biological process | positive regulation of cell division |
| GO_0010002 | Biological process | cardioblast differentiation |
| GO_0008285 | Biological process | negative regulation of cell population proliferation |
| GO_0045726 | Biological process | positive regulation of integrin biosynthetic process |
| GO_0010629 | Biological process | negative regulation of gene expression |
| GO_0030855 | Biological process | epithelial cell differentiation |
| GO_0030593 | Biological process | neutrophil chemotaxis |
| GO_0001822 | Biological process | kidney development |
| GO_0060391 | Biological process | positive regulation of SMAD protein signal transduction |
| GO_0051891 | Biological process | positive regulation of cardioblast differentiation |
| GO_0001654 | Biological process | eye development |
| GO_0046580 | Biological process | negative regulation of Ras protein signal transduction |
| GO_0045216 | Biological process | cell-cell junction organization |
| GO_0042060 | Biological process | wound healing |
| GO_0032147 | Biological process | activation of protein kinase activity |
| GO_0030326 | Biological process | embryonic limb morphogenesis |
| GO_1903659 | Biological process | regulation of complement-dependent cytotoxicity |
| GO_0001843 | Biological process | neural tube closure |
| GO_0060412 | Biological process | ventricular septum morphogenesis |
| GO_0003184 | Biological process | pulmonary valve morphogenesis |
| GO_0003007 | Biological process | heart morphogenesis |
| GO_0045787 | Biological process | positive regulation of cell cycle |
| GO_0030308 | Biological process | negative regulation of cell growth |
| GO_0003215 | Biological process | cardiac right ventricle morphogenesis |
| GO_0097191 | Biological process | extrinsic apoptotic signaling pathway |
| GO_0033630 | Biological process | positive regulation of cell adhesion mediated by integrin |
| GO_0003148 | Biological process | outflow tract septum morphogenesis |
| GO_0030097 | Biological process | hemopoiesis |
| GO_0032874 | Biological process | positive regulation of stress-activated MAPK cascade |
| GO_0031069 | Biological process | hair follicle morphogenesis |
| GO_0003181 | Biological process | atrioventricular valve morphogenesis |
| GO_0003179 | Biological process | heart valve morphogenesis |
| GO_0042704 | Biological process | uterine wall breakdown |
| GO_0050714 | Biological process | positive regulation of protein secretion |
| GO_0060038 | Biological process | cardiac muscle cell proliferation |
| GO_0048666 | Biological process | neuron development |
| GO_0060065 | Biological process | uterus development |
| GO_0008584 | Biological process | male gonad development |
| GO_0008284 | Biological process | positive regulation of cell population proliferation |
| GO_0030199 | Biological process | collagen fibril organization |
| GO_0009611 | Biological process | response to wounding |
| GO_0032570 | Biological process | response to progesterone |
| GO_0016477 | Biological process | cell migration |
| GO_0010634 | Biological process | positive regulation of epithelial cell migration |
| GO_0042127 | Biological process | regulation of cell population proliferation |
| GO_0023052 | Biological process | signaling |
| GO_0007435 | Biological process | salivary gland morphogenesis |
| GO_0003274 | Biological process | endocardial cushion fusion |
| GO_0051794 | Biological process | regulation of timing of catagen |
| GO_0001837 | Biological process | epithelial to mesenchymal transition |
| GO_0030307 | Biological process | positive regulation of cell growth |
| GO_0007507 | Biological process | heart development |
| GO_0062009 | Biological process | secondary palate development |
| GO_0060413 | Biological process | atrial septum morphogenesis |
| GO_0048839 | Biological process | inner ear development |
| GO_0050680 | Biological process | negative regulation of epithelial cell proliferation |
| GO_0043525 | Biological process | positive regulation of neuron apoptotic process |
| GO_0060317 | Biological process | cardiac epithelial to mesenchymal transition |
| GO_0016525 | Biological process | negative regulation of angiogenesis |
| GO_0048699 | Biological process | generation of neurons |
| GO_1902256 | Biological process | regulation of apoptotic process involved in outflow tract morphogenesis |
| GO_0001942 | Biological process | hair follicle development |
| GO_0008347 | Biological process | glial cell migration |
| GO_0010718 | Biological process | positive regulation of epithelial to mesenchymal transition |
| GO_0045823 | Biological process | positive regulation of heart contraction |
| GO_0010936 | Biological process | negative regulation of macrophage cytokine production |
| GO_0050778 | Biological process | positive regulation of immune response |
| GO_0003289 | Biological process | atrial septum primum morphogenesis |
| GO_0045747 | Biological process | positive regulation of Notch signaling pathway |
| GO_1905006 | Biological process | negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation |
| GO_0061626 | Biological process | pharyngeal arch artery morphogenesis |
| GO_0003222 | Biological process | ventricular trabecula myocardium morphogenesis |
| GO_0007179 | Biological process | transforming growth factor beta receptor signaling pathway |
| GO_0003407 | Biological process | neural retina development |
| GO_0043025 | Cellular component | neuronal cell body |
| GO_0005576 | Cellular component | extracellular region |
| GO_0031093 | Cellular component | platelet alpha granule lumen |
| GO_0005615 | Cellular component | extracellular space |
| GO_0030424 | Cellular component | axon |
| GO_0062023 | Cellular component | collagen-containing extracellular matrix |
| GO_0034714 | Molecular function | type III transforming growth factor beta receptor binding |
| GO_0001540 | Molecular function | amyloid-beta binding |
| GO_0005102 | Molecular function | signaling receptor binding |
| GO_0005125 | Molecular function | cytokine activity |
| GO_0005114 | Molecular function | type II transforming growth factor beta receptor binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0042803 | Molecular function | protein homodimerization activity |
| GO_0008083 | Molecular function | growth factor activity |
| GO_0005160 | Molecular function | transforming growth factor beta receptor binding |
| Gene name | TGFB2 |
| Protein name | Transforming growth factor beta-2 proprotein (Cetermin) (Glioblastoma-derived T-cell suppressor factor) (G-TSF) [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-2 (TGF-beta-2)] |
| Synonyms | |
| Description | FUNCTION: [Transforming growth factor beta-2 proprotein]: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively. .; FUNCTION: [Latency-associated peptide]: Required to maintain the Transforming growth factor beta-2 (TGF-beta-2) chain in a latent state during storage in extracellular matrix (By similarity). Associates non-covalently with TGF-beta-2 and regulates its activation via interaction with 'milieu molecules', such as LTBP1 and LRRC32/GARP, that control activation of TGF-beta-2 (By similarity). .; FUNCTION: [Transforming growth factor beta-2]: Multifunctional protein that regulates various processes such as angiogenesis and heart development . Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains remain non-covalently linked rendering TGF-beta-2 inactive during storage in extracellular matrix (By similarity). At the same time, LAP chain interacts with 'milieu molecules', such as LTBP1 and LRRC32/GARP, that control activation of TGF-beta-2 and maintain it in a latent state during storage in extracellular milieus (By similarity). Once activated following release of LAP, TGF-beta-2 acts by binding to TGF-beta receptors (TGFBR1 and TGFBR2), which transduce signal (By similarity). . |
| Accessions | ENST00000366930.9 [P61812-1] ENST00000366929.4 [P61812-2] P61812 |
