SMAD4 | OmnibusX

Name	Number of supported studies	Average coverage
endothelial cell	10 studies	25% ± 8%	Explore
astrocyte	8 studies	32% ± 12%	Explore
microglial cell	7 studies	24% ± 8%	Explore
oligodendrocyte	7 studies	24% ± 8%	Explore
epithelial cell	6 studies	32% ± 13%	Explore
oligodendrocyte precursor cell	6 studies	27% ± 11%	Explore
lymphocyte	4 studies	16% ± 0%	Explore
GABAergic neuron	4 studies	35% ± 10%	Explore
macrophage	4 studies	21% ± 3%	Explore
myeloid cell	3 studies	18% ± 2%	Explore
basal cell	3 studies	25% ± 7%	Explore
glutamatergic neuron	3 studies	48% ± 11%	Explore
goblet cell	3 studies	29% ± 11%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	6 studies	34% ± 15%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
prostate	100%	6380.71	245 / 245	100%	26.56	502 / 502
thymus	100%	6590.42	653 / 653	100%	21.46	604 / 605
lung	100%	5496.63	578 / 578	100%	15.17	1153 / 1155
ovary	100%	6818.52	180 / 180	100%	13.56	429 / 430
breast	100%	5956.59	459 / 459	100%	18.46	1113 / 1118
brain	99%	3244.40	2628 / 2642	100%	20.16	705 / 705
kidney	100%	3980.03	89 / 89	99%	16.40	895 / 901
bladder	100%	6002.24	21 / 21	99%	12.60	500 / 504
liver	100%	3054.98	226 / 226	99%	10.87	401 / 406
pancreas	100%	3213.16	328 / 328	98%	12.54	175 / 178
uterus	100%	7204.29	170 / 170	98%	16.09	450 / 459
esophagus	100%	5421.74	1445 / 1445	97%	12.76	178 / 183
intestine	100%	6056.82	966 / 966	97%	10.87	511 / 527
stomach	100%	4304.83	359 / 359	97%	10.84	277 / 286
skin	100%	5081.32	1809 / 1809	96%	14.86	452 / 472
adrenal gland	100%	4270.15	258 / 258	94%	12.02	216 / 230
adipose	100%	5729.92	1204 / 1204	0%	0	0 / 0
blood vessel	100%	5811.38	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	12.24	29 / 29
muscle	100%	6052.89	803 / 803	0%	0	0 / 0
spleen	100%	4729.28	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	15.76	45 / 45
heart	99%	3361.56	851 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	93%	10.22	74 / 80
peripheral blood	82%	2118.30	760 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0006366	Biological process	transcription by RNA polymerase II
GO_0001658	Biological process	branching involved in ureteric bud morphogenesis
GO_0071560	Biological process	cellular response to transforming growth factor beta stimulus
GO_0008283	Biological process	cell population proliferation
GO_0001541	Biological process	ovarian follicle development
GO_0042733	Biological process	embryonic digit morphogenesis
GO_0071559	Biological process	response to transforming growth factor beta
GO_0090090	Biological process	negative regulation of canonical Wnt signaling pathway
GO_0030509	Biological process	BMP signaling pathway
GO_0060395	Biological process	SMAD protein signal transduction
GO_0003220	Biological process	left ventricular cardiac muscle tissue morphogenesis
GO_0001666	Biological process	response to hypoxia
GO_1902895	Biological process	positive regulation of miRNA transcription
GO_0014033	Biological process	neural crest cell differentiation
GO_0048589	Biological process	developmental growth
GO_0048733	Biological process	sebaceous gland development
GO_0032909	Biological process	regulation of transforming growth factor beta2 production
GO_0033686	Biological process	positive regulation of luteinizing hormone secretion
GO_0042177	Biological process	negative regulation of protein catabolic process
GO_0003161	Biological process	cardiac conduction system development
GO_0008285	Biological process	negative regulation of cell population proliferation
GO_0071333	Biological process	cellular response to glucose stimulus
GO_0003190	Biological process	atrioventricular valve formation
GO_0071773	Biological process	cellular response to BMP stimulus
GO_0001701	Biological process	in utero embryonic development
GO_0006357	Biological process	regulation of transcription by RNA polymerase II
GO_0001649	Biological process	osteoblast differentiation
GO_0010628	Biological process	positive regulation of gene expression
GO_0048665	Biological process	neuron fate specification
GO_0060391	Biological process	positive regulation of SMAD protein signal transduction
GO_0072520	Biological process	seminiferous tubule development
GO_1901203	Biological process	positive regulation of extracellular matrix assembly
GO_0006351	Biological process	DNA-templated transcription
GO_0070371	Biological process	ERK1 and ERK2 cascade
GO_0006879	Biological process	intracellular iron ion homeostasis
GO_0003251	Biological process	positive regulation of cell proliferation involved in heart valve morphogenesis
GO_0030325	Biological process	adrenal gland development
GO_0006355	Biological process	regulation of DNA-templated transcription
GO_0060412	Biological process	ventricular septum morphogenesis
GO_0036302	Biological process	atrioventricular canal development
GO_0009653	Biological process	anatomical structure morphogenesis
GO_0046881	Biological process	positive regulation of follicle-stimulating hormone secretion
GO_0061040	Biological process	female gonad morphogenesis
GO_0030308	Biological process	negative regulation of cell growth
GO_0097191	Biological process	extrinsic apoptotic signaling pathway
GO_0003198	Biological process	epithelial to mesenchymal transition involved in endocardial cushion formation
GO_0003148	Biological process	outflow tract septum morphogenesis
GO_0072134	Biological process	nephrogenic mesenchyme morphogenesis
GO_0014898	Biological process	cardiac muscle hypertrophy in response to stress
GO_0010631	Biological process	epithelial cell migration
GO_0032525	Biological process	somite rostral/caudal axis specification
GO_0070373	Biological process	negative regulation of ERK1 and ERK2 cascade
GO_0042118	Biological process	endothelial cell activation
GO_0048382	Biological process	mesendoderm development
GO_0045893	Biological process	positive regulation of DNA-templated transcription
GO_0060065	Biological process	uterus development
GO_0051797	Biological process	regulation of hair follicle development
GO_1905305	Biological process	negative regulation of cardiac myofibril assembly
GO_0007338	Biological process	single fertilization
GO_0048859	Biological process	formation of anatomical boundary
GO_0045892	Biological process	negative regulation of DNA-templated transcription
GO_0010614	Biological process	negative regulation of cardiac muscle hypertrophy
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_0001702	Biological process	gastrulation with mouth forming second
GO_0030511	Biological process	positive regulation of transforming growth factor beta receptor signaling pathway
GO_0032924	Biological process	activin receptor signaling pathway
GO_0001837	Biological process	epithelial to mesenchymal transition
GO_0007283	Biological process	spermatogenesis
GO_0072133	Biological process	metanephric mesenchyme morphogenesis
GO_0062009	Biological process	secondary palate development
GO_0010666	Biological process	positive regulation of cardiac muscle cell apoptotic process
GO_0000122	Biological process	negative regulation of transcription by RNA polymerase II
GO_0060956	Biological process	endocardial cell differentiation
GO_0070102	Biological process	interleukin-6-mediated signaling pathway
GO_0035556	Biological process	intracellular signal transduction
GO_0030154	Biological process	cell differentiation
GO_0003360	Biological process	brainstem development
GO_0010718	Biological process	positive regulation of epithelial to mesenchymal transition
GO_0007179	Biological process	transforming growth factor beta receptor signaling pathway
GO_0007411	Biological process	axon guidance
GO_0005634	Cellular component	nucleus
GO_0071141	Cellular component	SMAD protein complex
GO_0005654	Cellular component	nucleoplasm
GO_0005813	Cellular component	centrosome
GO_0005737	Cellular component	cytoplasm
GO_0000785	Cellular component	chromatin
GO_0005667	Cellular component	transcription regulator complex
GO_0005829	Cellular component	cytosol
GO_0032444	Cellular component	activin responsive factor complex
GO_0071144	Cellular component	heteromeric SMAD protein complex
GO_0001228	Molecular function	DNA-binding transcription activator activity, RNA polymerase II-specific
GO_0001222	Molecular function	transcription corepressor binding
GO_0042802	Molecular function	identical protein binding
GO_0001223	Molecular function	transcription coactivator binding
GO_0000978	Molecular function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0043565	Molecular function	sequence-specific DNA binding
GO_0003682	Molecular function	chromatin binding
GO_0061629	Molecular function	RNA polymerase II-specific DNA-binding transcription factor binding
GO_0046872	Molecular function	metal ion binding
GO_0005518	Molecular function	collagen binding
GO_0000976	Molecular function	transcription cis-regulatory region binding
GO_0003700	Molecular function	DNA-binding transcription factor activity
GO_0005515	Molecular function	protein binding
GO_0043199	Molecular function	sulfate binding
GO_0003677	Molecular function	DNA binding
GO_0042803	Molecular function	protein homodimerization activity
GO_0070412	Molecular function	R-SMAD binding
GO_0000981	Molecular function	DNA-binding transcription factor activity, RNA polymerase II-specific
GO_0031005	Molecular function	filamin binding
GO_0070411	Molecular function	I-SMAD binding

IV. Literature review

[source]

Gene name	SMAD4
Protein name	SMAD4 Mothers against decapentaplegic homolog 4 (MAD homolog 4) (Mothers against DPP homolog 4) (Deletion target in pancreatic carcinoma 4) (SMAD family member 4) (SMAD 4) (Smad4) (hSMAD4) Mothers against decapentaplegic homolog (MAD homolog) (Mothers against DPP homolog) (SMAD family member) SMAD family member 4
Synonyms	MADH4 DPC4
Description	FUNCTION: In muscle physiology, plays a central role in the balance between atrophy and hypertrophy. When recruited by MSTN, promotes atrophy response via phosphorylated SMAD2/4. MSTN decrease causes SMAD4 release and subsequent recruitment by the BMP pathway to promote hypertrophy via phosphorylated SMAD1/5/8. Acts synergistically with SMAD1 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression. Binds to SMAD binding elements (SBEs) (5'-GTCT/AGAC-3') within BMP response element (BMPRE) of cardiac activating regions (By similarity). Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling . Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site; required for synergistic transcriptional activity in response to TGF-beta. May act as a tumor suppressor. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. .
Accessions	ENST00000589941.2 ENST00000398417.6 ENST00000611848.2 Q13485 K7ENG1 Q9BYG6 ENST00000589076.6 ENST00000593223.2 ENST00000590061.2 K7ELK2 K7EL18 K7EIU8 A0A087WUF3 U6BGT8 ENST00000589076.5 A0A024R274 ENST00000589941.1 K7EIJ2 K7EL15 K7ES96 ENST00000342988.8 ENST00000588860.6 ENST00000590061.1 ENST00000588745.5 ENST00000592186.5 ENST00000588860.5 U6BKH8

SMAD4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review