PRDX2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0097191Biological processextrinsic apoptotic signaling pathway
GO_0043029Biological processT cell homeostasis
GO_0045454Biological processcell redox homeostasis
GO_0033554Biological processcellular response to stress
GO_0045581Biological processnegative regulation of T cell differentiation
GO_0042098Biological processT cell proliferation
GO_0042744Biological processhydrogen peroxide catabolic process
GO_0043410Biological processpositive regulation of MAPK cascade
GO_0045321Biological processleukocyte activation
GO_0034599Biological processcellular response to oxidative stress
GO_0042981Biological processregulation of apoptotic process
GO_0043066Biological processnegative regulation of apoptotic process
GO_0048538Biological processthymus development
GO_0002536Biological processrespiratory burst involved in inflammatory response
GO_0030194Biological processpositive regulation of blood coagulation
GO_0031665Biological processnegative regulation of lipopolysaccharide-mediated signaling pathway
GO_0002357Biological processdefense response to tumor cell
GO_2001240Biological processnegative regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO_0019430Biological processremoval of superoxide radicals
GO_0006979Biological processresponse to oxidative stress
GO_0010310Biological processregulation of hydrogen peroxide metabolic process
GO_0032496Biological processresponse to lipopolysaccharide
GO_0070062Cellular componentextracellular exosome
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0008379Molecular functionthioredoxin peroxidase activity
GO_0016209Molecular functionantioxidant activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePRDX2
Protein namePeroxiredoxin-2 (EC 1.11.1.24) (Thioredoxin-dependent peroxiredoxin 2)
Peroxiredoxin-2 (EC 1.11.1.24) (Natural killer cell-enhancing factor B) (NKEF-B) (PRP) (Thiol-specific antioxidant protein) (TSA) (Thioredoxin peroxidase 1) (Thioredoxin-dependent peroxide reductase 1) (Thioredoxin-dependent peroxiredoxin 2)
SynonymsNKEFB
TDPX1
HEL-S-2a
hCG_172488
DescriptionFUNCTION: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2). .

FUNCTION: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2). .

FUNCTION: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2). .

AccessionsP32119
V9HW12
A6NIW5
ENST00000334482.9
ENST00000301522.3 [P32119-1]