JAK2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006366Biological processtranscription by RNA polymerase II
GO_0030041Biological processactin filament polymerization
GO_0033194Biological processresponse to hydroperoxide
GO_0034050Biological processsymbiont-induced defense-related programmed cell death
GO_0006955Biological processimmune response
GO_0035166Biological processpost-embryonic hemopoiesis
GO_0070671Biological processresponse to interleukin-12
GO_0120162Biological processpositive regulation of cold-induced thermogenesis
GO_0051897Biological processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_2001235Biological processpositive regulation of apoptotic signaling pathway
GO_0006468Biological processprotein phosphorylation
GO_1904707Biological processpositive regulation of vascular associated smooth muscle cell proliferation
GO_1905539Biological processregulation of postsynapse to nucleus signaling pathway
GO_0032740Biological processpositive regulation of interleukin-17 production
GO_0042102Biological processpositive regulation of T cell proliferation
GO_0006919Biological processactivation of cysteine-type endopeptidase activity involved in apoptotic process
GO_0008285Biological processnegative regulation of cell population proliferation
GO_0038156Biological processinterleukin-3-mediated signaling pathway
GO_0045348Biological processpositive regulation of MHC class II biosynthetic process
GO_0071549Biological processcellular response to dexamethasone stimulus
GO_0038043Biological processinterleukin-5-mediated signaling pathway
GO_2000273Biological processpositive regulation of signaling receptor activity
GO_0010811Biological processpositive regulation of cell-substrate adhesion
GO_2000318Biological processpositive regulation of T-helper 17 type immune response
GO_0007165Biological processsignal transduction
GO_0060396Biological processgrowth hormone receptor signaling pathway
GO_0042307Biological processpositive regulation of protein import into nucleus
GO_0060333Biological processtype II interferon-mediated signaling pathway
GO_0060391Biological processpositive regulation of SMAD protein signal transduction
GO_0050727Biological processregulation of inflammatory response
GO_0043687Biological processpost-translational protein modification
GO_0007186Biological processG protein-coupled receptor signaling pathway
GO_0042981Biological processregulation of apoptotic process
GO_0045429Biological processpositive regulation of nitric oxide biosynthetic process
GO_0043392Biological processnegative regulation of DNA binding
GO_0035722Biological processinterleukin-12-mediated signaling pathway
GO_0071222Biological processcellular response to lipopolysaccharide
GO_0010667Biological processnegative regulation of cardiac muscle cell apoptotic process
GO_0008631Biological processintrinsic apoptotic signaling pathway in response to oxidative stress
GO_0046777Biological processprotein autophosphorylation
GO_0032760Biological processpositive regulation of tumor necrosis factor production
GO_0038157Biological processgranulocyte-macrophage colony-stimulating factor signaling pathway
GO_0007259Biological processcell surface receptor signaling pathway via JAK-STAT
GO_0022408Biological processnegative regulation of cell-cell adhesion
GO_0042531Biological processpositive regulation of tyrosine phosphorylation of STAT protein
GO_0097191Biological processextrinsic apoptotic signaling pathway
GO_0070757Biological processinterleukin-35-mediated signaling pathway
GO_0031103Biological processaxon regeneration
GO_0051770Biological processpositive regulation of nitric-oxide synthase biosynthetic process
GO_0036016Biological processcellular response to interleukin-3
GO_0001774Biological processmicroglial cell activation
GO_0060397Biological processgrowth hormone receptor signaling pathway via JAK-STAT
GO_0031959Biological processnuclear receptor-mediated mineralocorticoid signaling pathway
GO_0034612Biological processresponse to tumor necrosis factor
GO_0032024Biological processpositive regulation of insulin secretion
GO_1904037Biological processpositive regulation of epithelial cell apoptotic process
GO_0032731Biological processpositive regulation of interleukin-1 beta production
GO_0061180Biological processmammary gland epithelium development
GO_0045597Biological processpositive regulation of cell differentiation
GO_0007204Biological processpositive regulation of cytosolic calcium ion concentration
GO_1902728Biological processpositive regulation of growth factor dependent skeletal muscle satellite cell proliferation
GO_0046677Biological processresponse to antibiotic
GO_0010572Biological processpositive regulation of platelet activation
GO_0043524Biological processnegative regulation of neuron apoptotic process
GO_0046427Biological processpositive regulation of receptor signaling pathway via JAK-STAT
GO_0033209Biological processtumor necrosis factor-mediated signaling pathway
GO_0070665Biological processpositive regulation of leukocyte proliferation
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0060399Biological processpositive regulation of growth hormone receptor signaling pathway
GO_0019221Biological processcytokine-mediated signaling pathway
GO_0007498Biological processmesoderm development
GO_0042976Biological processactivation of Janus kinase activity
GO_0014075Biological processresponse to amine
GO_0007260Biological processtyrosine phosphorylation of STAT protein
GO_0050804Biological processmodulation of chemical synaptic transmission
GO_0045428Biological processregulation of nitric oxide biosynthetic process
GO_0032819Biological processpositive regulation of natural killer cell proliferation
GO_0038065Biological processcollagen-activated signaling pathway
GO_0007167Biological processenzyme-linked receptor protein signaling pathway
GO_0043410Biological processpositive regulation of MAPK cascade
GO_0006338Biological processchromatin remodeling
GO_0048008Biological processplatelet-derived growth factor receptor signaling pathway
GO_0002250Biological processadaptive immune response
GO_0098586Biological processcellular response to virus
GO_0030218Biological processerythrocyte differentiation
GO_0018108Biological processpeptidyl-tyrosine phosphorylation
GO_0070102Biological processinterleukin-6-mediated signaling pathway
GO_0035556Biological processintracellular signal transduction
GO_0030335Biological processpositive regulation of cell migration
GO_0051142Biological processpositive regulation of NK T cell proliferation
GO_0030154Biological processcell differentiation
GO_1901731Biological processpositive regulation of platelet aggregation
GO_0006915Biological processapoptotic process
GO_0032729Biological processpositive regulation of type II interferon production
GO_0097296Biological processactivation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO_0046425Biological processregulation of receptor signaling pathway via JAK-STAT
GO_0032496Biological processresponse to lipopolysaccharide
GO_0098978Cellular componentglutamatergic synapse
GO_0005856Cellular componentcytoskeleton
GO_0045121Cellular componentmembrane raft
GO_0031234Cellular componentextrinsic component of cytoplasmic side of plasma membrane
GO_0098794Cellular componentpostsynapse
GO_0031904Cellular componentendosome lumen
GO_0005634Cellular componentnucleus
GO_0019897Cellular componentextrinsic component of plasma membrane
GO_0005654Cellular componentnucleoplasm
GO_0030526Cellular componentgranulocyte macrophage colony-stimulating factor receptor complex
GO_0005886Cellular componentplasma membrane
GO_0000791Cellular componenteuchromatin
GO_0005737Cellular componentcytoplasm
GO_0005901Cellular componentcaveola
GO_0072536Cellular componentinterleukin-23 receptor complex
GO_0042022Cellular componentinterleukin-12 receptor complex
GO_0005925Cellular componentfocal adhesion
GO_0005829Cellular componentcytosol
GO_0043548Molecular functionphosphatidylinositol 3-kinase binding
GO_0042802Molecular functionidentical protein binding
GO_0004672Molecular functionprotein kinase activity
GO_0042169Molecular functionSH2 domain binding
GO_0005131Molecular functiongrowth hormone receptor binding
GO_0005524Molecular functionATP binding
GO_0031702Molecular functiontype 1 angiotensin receptor binding
GO_0042393Molecular functionhistone binding
GO_0035401Molecular functionhistone H3Y41 kinase activity
GO_0005102Molecular functionsignaling receptor binding
GO_0046872Molecular functionmetal ion binding
GO_0004715Molecular functionnon-membrane spanning protein tyrosine kinase activity
GO_0004713Molecular functionprotein tyrosine kinase activity
GO_0005515Molecular functionprotein binding
GO_0051428Molecular functionpeptide hormone receptor binding
GO_0019901Molecular functionprotein kinase binding
GO_0043560Molecular functioninsulin receptor substrate binding
GO_0020037Molecular functionheme binding
GO_0033130Molecular functionacetylcholine receptor binding
GO_0005143Molecular functioninterleukin-12 receptor binding

IV. Literature review

[source]
Gene nameJAK2
Protein nameTyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2)
Tyrosine-protein kinase (EC 2.7.10.2)
Janus kinase 2
Janus kinase
Synonyms
DescriptionFUNCTION: Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple interleukins . Following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins . Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, cell stimulation with erythropoietin (EPO) during erythropoiesis leads to JAK2 autophosphorylation, activation, and its association with erythropoietin receptor (EPOR) that becomes phosphorylated in its cytoplasmic domain. Then, STAT5 (STAT5A or STAT5B) is recruited, phosphorylated and activated by JAK2. Once activated, dimerized STAT5 translocates into the nucleus and promotes the transcription of several essential genes involved in the modulation of erythropoiesis. Part of a signaling cascade that is activated by increased cellular retinol and that leads to the activation of STAT5 (STAT5A or STAT5B) . In addition, JAK2 mediates angiotensin-2-induced ARHGEF1 phosphorylation . Plays a role in cell cycle by phosphorylating CDKN1B . Cooperates with TEC through reciprocal phosphorylation to mediate cytokine-driven activation of FOS transcription. In the nucleus, plays a key role in chromatin by specifically mediating phosphorylation of 'Tyr-41' of histone H3 (H3Y41ph), a specific tag that promotes exclusion of CBX5 (HP1 alpha) from chromatin . .

AccessionsA0A1B0GVR5
A9QVL8
A0A1B0GTR9
O60674
Q506Q0
ENST00000636127.1
ENST00000476574.5
Q52R86
Q8IXP2
ENST00000381652.4