SFRP1 | OmnibusX

Name	Number of supported studies	Average coverage
fibroblast	14 studies	31% ± 13%	Explore
connective tissue cell	9 studies	40% ± 19%	Explore
smooth muscle cell	5 studies	29% ± 12%	Explore
kidney loop of Henle epithelial cell	4 studies	31% ± 11%	Explore
endothelial cell of lymphatic vessel	3 studies	17% ± 1%	Explore
endothelial cell	3 studies	29% ± 14%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	59% ± 14%	Explore
retinal pigment epithelial cell	3 studies	41% ± 10%	Explore
adventitial cell	3 studies	24% ± 5%	Explore
basal cell	3 studies	57% ± 28%	Explore
myoepithelial cell	3 studies	51% ± 7%	Explore
progenitor cell of mammary luminal epithelium	3 studies	67% ± 25%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
breast	3 studies	30% ± 5%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
prostate	97%	7239.75	238 / 245	95%	60.16	479 / 502
breast	100%	16722.23	457 / 459	67%	133.37	751 / 1118
uterus	98%	11714.63	167 / 170	64%	68.36	292 / 459
skin	90%	8428.12	1631 / 1809	67%	281.97	317 / 472
ovary	96%	4921.49	173 / 180	36%	18.85	154 / 430
esophagus	93%	2892.84	1345 / 1445	31%	24.59	57 / 183
kidney	100%	10593.49	89 / 89	16%	7.04	142 / 901
bladder	86%	3717.05	18 / 21	19%	8.53	95 / 504
adipose	96%	4934.03	1155 / 1204	0%	0	0 / 0
brain	58%	1363.57	1526 / 2642	35%	10.76	249 / 705
adrenal gland	32%	574.79	83 / 258	61%	44.70	140 / 230
blood vessel	91%	6424.43	1212 / 1335	0%	0	0 / 0
intestine	77%	2941.99	745 / 966	10%	3.14	51 / 527
stomach	62%	4210.27	223 / 359	17%	7.25	50 / 286
heart	71%	3156.95	608 / 861	0%	0	0 / 0
thymus	47%	986.46	308 / 653	16%	31.02	99 / 605
eye	0%	0	0 / 0	59%	20.21	47 / 80
spleen	54%	1361.14	131 / 241	0%	0	0 / 0
lung	26%	592.84	152 / 578	22%	13.04	257 / 1155
pancreas	3%	43.80	11 / 328	45%	19.19	80 / 178
tonsil	0%	0	0 / 0	33%	26.77	15 / 45
muscle	5%	84.50	38 / 803	0%	0	0 / 0
liver	2%	28.12	5 / 226	2%	0.55	9 / 406
peripheral blood	0%	15.27	3 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0071560	Biological process	cellular response to transforming growth factor beta stimulus
GO_0060527	Biological process	prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
GO_0048147	Biological process	negative regulation of fibroblast proliferation
GO_0033689	Biological process	negative regulation of osteoblast proliferation
GO_0044345	Biological process	stromal-epithelial cell signaling involved in prostate gland development
GO_0071392	Biological process	cellular response to estradiol stimulus
GO_1902043	Biological process	positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO_0030514	Biological process	negative regulation of BMP signaling pathway
GO_0009267	Biological process	cellular response to starvation
GO_0090090	Biological process	negative regulation of canonical Wnt signaling pathway
GO_0046676	Biological process	negative regulation of insulin secretion
GO_2000271	Biological process	positive regulation of fibroblast apoptotic process
GO_0030509	Biological process	BMP signaling pathway
GO_0060218	Biological process	hematopoietic stem cell differentiation
GO_0043066	Biological process	negative regulation of apoptotic process
GO_0060766	Biological process	negative regulation of androgen receptor signaling pathway
GO_0046851	Biological process	negative regulation of bone remodeling
GO_0009410	Biological process	response to xenobiotic stimulus
GO_0030279	Biological process	negative regulation of ossification
GO_0002244	Biological process	hematopoietic progenitor cell differentiation
GO_0001657	Biological process	ureteric bud development
GO_0008285	Biological process	negative regulation of cell population proliferation
GO_2000270	Biological process	negative regulation of fibroblast apoptotic process
GO_0071773	Biological process	cellular response to BMP stimulus
GO_0043547	Biological process	positive regulation of GTPase activity
GO_0010629	Biological process	negative regulation of gene expression
GO_0001649	Biological process	osteoblast differentiation
GO_1904956	Biological process	regulation of midbrain dopaminergic neuron differentiation
GO_0071347	Biological process	cellular response to interleukin-1
GO_2000041	Biological process	negative regulation of planar cell polarity pathway involved in axis elongation
GO_0045765	Biological process	regulation of angiogenesis
GO_0050679	Biological process	positive regulation of epithelial cell proliferation
GO_0010975	Biological process	regulation of neuron projection development
GO_0030336	Biological process	negative regulation of cell migration
GO_0035567	Biological process	non-canonical Wnt signaling pathway
GO_0090246	Biological process	convergent extension involved in somitogenesis
GO_0048546	Biological process	digestive tract morphogenesis
GO_2000052	Biological process	positive regulation of non-canonical Wnt signaling pathway
GO_0030177	Biological process	positive regulation of Wnt signaling pathway
GO_0030308	Biological process	negative regulation of cell growth
GO_0071380	Biological process	cellular response to prostaglandin E stimulus
GO_0097191	Biological process	extrinsic apoptotic signaling pathway
GO_0030316	Biological process	osteoclast differentiation
GO_0090263	Biological process	positive regulation of canonical Wnt signaling pathway
GO_0003402	Biological process	planar cell polarity pathway involved in axis elongation
GO_0051496	Biological process	positive regulation of stress fiber assembly
GO_0014034	Biological process	neural crest cell fate commitment
GO_0071391	Biological process	cellular response to estrogen stimulus
GO_0071363	Biological process	cellular response to growth factor stimulus
GO_0009950	Biological process	dorsal/ventral axis specification
GO_0045893	Biological process	positive regulation of DNA-templated transcription
GO_0010564	Biological process	regulation of cell cycle process
GO_0045668	Biological process	negative regulation of osteoblast differentiation
GO_0051894	Biological process	positive regulation of focal adhesion assembly
GO_0008584	Biological process	male gonad development
GO_0008284	Biological process	positive regulation of cell population proliferation
GO_1904692	Biological process	positive regulation of type B pancreatic cell proliferation
GO_0090244	Biological process	Wnt signaling pathway involved in somitogenesis
GO_0060687	Biological process	regulation of branching involved in prostate gland morphogenesis
GO_0043065	Biological process	positive regulation of apoptotic process
GO_0045578	Biological process	negative regulation of B cell differentiation
GO_0045892	Biological process	negative regulation of DNA-templated transcription
GO_0035019	Biological process	somatic stem cell population maintenance
GO_0060346	Biological process	bone trabecula formation
GO_0030307	Biological process	positive regulation of cell growth
GO_0071305	Biological process	cellular response to vitamin D
GO_0071504	Biological process	cellular response to heparin
GO_0001954	Biological process	positive regulation of cell-matrix adhesion
GO_0014070	Biological process	response to organic cyclic compound
GO_0071542	Biological process	dopaminergic neuron differentiation
GO_0050680	Biological process	negative regulation of epithelial cell proliferation
GO_0060070	Biological process	canonical Wnt signaling pathway
GO_0090179	Biological process	planar cell polarity pathway involved in neural tube closure
GO_0045880	Biological process	positive regulation of smoothened signaling pathway
GO_0050732	Biological process	negative regulation of peptidyl-tyrosine phosphorylation
GO_0030178	Biological process	negative regulation of Wnt signaling pathway
GO_0071356	Biological process	cellular response to tumor necrosis factor
GO_0010719	Biological process	negative regulation of epithelial to mesenchymal transition
GO_0071481	Biological process	cellular response to X-ray
GO_0045600	Biological process	positive regulation of fat cell differentiation
GO_0008585	Biological process	female gonad development
GO_0044344	Biological process	cellular response to fibroblast growth factor stimulus
GO_0045671	Biological process	negative regulation of osteoclast differentiation
GO_0071456	Biological process	cellular response to hypoxia
GO_0009986	Cellular component	cell surface
GO_0005576	Cellular component	extracellular region
GO_0070062	Cellular component	extracellular exosome
GO_0005615	Cellular component	extracellular space
GO_0005886	Cellular component	plasma membrane
GO_0062023	Cellular component	collagen-containing extracellular matrix
GO_0005829	Cellular component	cytosol
GO_0042802	Molecular function	identical protein binding
GO_0008201	Molecular function	heparin binding
GO_0004197	Molecular function	cysteine-type endopeptidase activity
GO_0005515	Molecular function	protein binding
GO_0017147	Molecular function	Wnt-protein binding
GO_0005109	Molecular function	frizzled binding

Gene name	SFRP1
Protein name	Secreted frizzled-related protein 1 (FRP-1) (sFRP-1) (Secreted apoptosis-related protein 2) (SARP-2) SFRP1 protein Secreted frizzled related protein 1 (Secreted frizzled-related protein 1, isoform CRA_a) (cDNA FLJ45402 fis, clone BRHIP3029409, moderately similar to Homo sapiens secreted frizzled-related protein 1 (SFRP1))
Synonyms	SARP2 FRP FRP1 hCG_2044540
Description	FUNCTION: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP1 decreases intracellular beta-catenin levels (By similarity). Has antiproliferative effects on vascular cells, in vitro and in vivo, and can induce, in vivo, an angiogenic response. In vascular cell cycle, delays the G1 phase and entry into the S phase (By similarity). In kidney development, inhibits tubule formation and bud growth in metanephroi (By similarity). Inhibits WNT1/WNT4-mediated TCF-dependent transcription. .
Accessions	Q6ZSL4 ENST00000379845.3 Q05DS5 ENST00000220772.8 Q8N474

SFRP1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review