IL6R report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0042531Biological processpositive regulation of tyrosine phosphorylation of STAT protein
GO_0097191Biological processextrinsic apoptotic signaling pathway
GO_0019221Biological processcytokine-mediated signaling pathway
GO_0010573Biological processvascular endothelial growth factor production
GO_0032722Biological processpositive regulation of chemokine production
GO_0010536Biological processpositive regulation of activation of Janus kinase activity
GO_0006953Biological processacute-phase response
GO_0072126Biological processpositive regulation of glomerular mesangial cell proliferation
GO_0002384Biological processhepatic immune response
GO_0034097Biological processresponse to cytokine
GO_0050829Biological processdefense response to Gram-negative bacterium
GO_0048661Biological processpositive regulation of smooth muscle cell proliferation
GO_0038154Biological processinterleukin-11-mediated signaling pathway
GO_0045669Biological processpositive regulation of osteoblast differentiation
GO_0070120Biological processciliary neurotrophic factor-mediated signaling pathway
GO_0070102Biological processinterleukin-6-mediated signaling pathway
GO_0050731Biological processpositive regulation of peptidyl-tyrosine phosphorylation
GO_0072540Biological processT-helper 17 cell lineage commitment
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0031018Biological processendocrine pancreas development
GO_0002548Biological processmonocyte chemotaxis
GO_0002690Biological processpositive regulation of leukocyte chemotaxis
GO_0032755Biological processpositive regulation of interleukin-6 production
GO_0005896Cellular componentinterleukin-6 receptor complex
GO_0016324Cellular componentapical plasma membrane
GO_0009897Cellular componentexternal side of plasma membrane
GO_0043235Cellular componentreceptor complex
GO_0005576Cellular componentextracellular region
GO_0005886Cellular componentplasma membrane
GO_0070110Cellular componentciliary neurotrophic factor receptor complex
GO_0019970Molecular functioninterleukin-11 binding
GO_0019899Molecular functionenzyme binding
GO_0070119Molecular functionciliary neurotrophic factor binding
GO_0042803Molecular functionprotein homodimerization activity
GO_0004897Molecular functionciliary neurotrophic factor receptor activity
GO_0004915Molecular functioninterleukin-6 receptor activity
GO_0004921Molecular functioninterleukin-11 receptor activity
GO_0005138Molecular functioninterleukin-6 receptor binding
GO_0019981Molecular functioninterleukin-6 binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameIL6R
Protein nameInterleukin 6 receptor
Interleukin-6 receptor subunit alpha (IL-6 receptor subunit alpha) (IL-6R subunit alpha) (IL-6R-alpha) (IL-6RA) (IL-6R 1) (Membrane glycoprotein 80) (gp80) (CD antigen CD126) [Cleaved into: Soluble interleukin-6 receptor subunit alpha (sIL6R)]
SynonymshCG_1810911
DescriptionFUNCTION: Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal . Signal activation necessitate an association with IL6ST. Activation leads to the regulation of the immune response, acute-phase reactions and hematopoiesis . The interaction with membrane-bound IL6R and IL6ST stimulates 'classic signaling', the restricted expression of the IL6R limits classic IL6 signaling to only a few tissues such as the liver and some cells of the immune system. Whereas the binding of IL6 and soluble IL6R to IL6ST stimulates 'trans-signaling'. Alternatively, 'cluster signaling' occurs when membrane-bound IL6:IL6R complexes on transmitter cells activate IL6ST receptors on neighboring receiver cells (Probable). .; FUNCTION: [Isoform 1]: Signaling via the membrane-bound IL6R is mostly regenerative and anti-inflammatory (Probable). Drives naive CD4(+) T cells to the Th17 lineage, through 'cluster signaling' by dendritic cells (By similarity). .; FUNCTION: [Isoform 2]: Soluble form of IL6 receptor (sIL6R) that acts as an agonist of IL6 activity . The IL6:sIL6R complex (hyper-IL6) binds to IL6ST/gp130 on cell surfaces and induces signaling also on cells that do not express membrane-bound IL6R in a process called IL6 'trans-signaling'. sIL6R is causative for the pro-inflammatory properties of IL6 and an important player in the development of chronic inflammatory diseases . In complex with IL6, is required for induction of VEGF production . Plays a protective role during liver injury, being required for maintenance of tissue regeneration (By similarity). 'Trans-signaling' in central nervous system regulates energy and glucose homeostasis (By similarity). .; FUNCTION: [Soluble interleukin-6 receptor subunit alpha]: Soluble form of IL6 receptor (sIL6R) that acts as an agonist of IL6 activity . The IL6:sIL6R complex (hyper-IL6) binds to IL6ST/gp130 on cell surfaces and induces signaling also on cells that do not express membrane-bound IL6R in a process called IL6 'trans-signaling'. sIL6R is causative for the pro-inflammatory properties of IL6 and an important player in the development of chronic inflammatory diseases . In complex with IL6, is required for induction of VEGF production . Plays a protective role during liver injury, being required for maintenance of tissue regeneration (By similarity). 'Trans-signaling' in central nervous system regulates energy and glucose homeostasis (By similarity). .

AccessionsH0Y9B1
ENST00000344086.8 [P08887-2]
H0Y949
P08887
ENST00000368485.8 [P08887-1]
ENST00000515190.1
A0N0L5
D6R9R8
A0A087WTB5
ENST00000512471.1
ENST00000622330.5
ENST00000476006.5