SIVA1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
fibroblast	31 studies	34% ± 14%	Explore
natural killer cell	30 studies	28% ± 13%	Explore
endothelial cell	29 studies	34% ± 14%	Explore
CD8-positive, alpha-beta T cell	29 studies	33% ± 16%	Explore
T cell	26 studies	32% ± 10%	Explore
CD4-positive, alpha-beta T cell	26 studies	32% ± 15%	Explore
B cell	25 studies	29% ± 11%	Explore
pericyte	24 studies	35% ± 13%	Explore
smooth muscle cell	22 studies	37% ± 10%	Explore
macrophage	22 studies	24% ± 9%	Explore
plasmacytoid dendritic cell	21 studies	53% ± 15%	Explore
regulatory T cell	21 studies	30% ± 7%	Explore
conventional dendritic cell	19 studies	26% ± 13%	Explore
non-classical monocyte	19 studies	32% ± 15%	Explore
basal cell	17 studies	33% ± 16%	Explore
ciliated cell	16 studies	49% ± 19%	Explore
epithelial cell	16 studies	42% ± 20%	Explore
classical monocyte	15 studies	28% ± 10%	Explore
naive B cell	15 studies	22% ± 5%	Explore
connective tissue cell	15 studies	37% ± 14%	Explore
gamma-delta T cell	15 studies	32% ± 15%	Explore
memory B cell	15 studies	25% ± 6%	Explore
endothelial cell of lymphatic vessel	14 studies	31% ± 8%	Explore
monocyte	14 studies	27% ± 9%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	14 studies	28% ± 5%	Explore
mature NK T cell	14 studies	23% ± 6%	Explore
mast cell	13 studies	27% ± 7%	Explore
plasma cell	13 studies	36% ± 12%	Explore
myofibroblast cell	13 studies	36% ± 11%	Explore
CD16-positive, CD56-dim natural killer cell, human	12 studies	24% ± 4%	Explore
CD16-negative, CD56-bright natural killer cell, human	12 studies	27% ± 6%	Explore
capillary endothelial cell	12 studies	24% ± 10%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	11 studies	32% ± 5%	Explore
vein endothelial cell	11 studies	30% ± 14%	Explore
CD8-positive, alpha-beta memory T cell	10 studies	31% ± 7%	Explore
abnormal cell	10 studies	31% ± 13%	Explore
endothelial cell of artery	10 studies	25% ± 7%	Explore
mucosal invariant T cell	10 studies	28% ± 5%	Explore
plasmablast	9 studies	45% ± 22%	Explore
secretory cell	9 studies	29% ± 12%	Explore
dendritic cell	9 studies	39% ± 24%	Explore
endothelial cell of vascular tree	9 studies	28% ± 8%	Explore
myeloid cell	9 studies	25% ± 13%	Explore
CD4-positive, alpha-beta memory T cell	8 studies	29% ± 6%	Explore
effector CD8-positive, alpha-beta T cell	8 studies	35% ± 13%	Explore
effector memory CD8-positive, alpha-beta T cell	8 studies	30% ± 10%	Explore
type I pneumocyte	7 studies	28% ± 12%	Explore
type II pneumocyte	7 studies	40% ± 16%	Explore
club cell	7 studies	31% ± 13%	Explore
progenitor cell	7 studies	47% ± 15%	Explore
innate lymphoid cell	7 studies	28% ± 4%	Explore
T follicular helper cell	7 studies	28% ± 3%	Explore
leukocyte	6 studies	31% ± 14%	Explore
goblet cell	6 studies	33% ± 13%	Explore
transit amplifying cell	6 studies	38% ± 19%	Explore
erythrocyte	6 studies	34% ± 23%	Explore
hematopoietic precursor cell	5 studies	45% ± 26%	Explore
exhausted T cell	5 studies	33% ± 3%	Explore
kidney loop of Henle epithelial cell	5 studies	20% ± 3%	Explore
epithelial cell of proximal tubule	5 studies	25% ± 6%	Explore
enteroendocrine cell	5 studies	38% ± 15%	Explore
mesothelial cell	5 studies	42% ± 15%	Explore
precursor B cell	5 studies	30% ± 14%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	34% ± 10%	Explore
respiratory goblet cell	4 studies	32% ± 20%	Explore
enterocyte	4 studies	26% ± 7%	Explore
intestinal crypt stem cell	4 studies	29% ± 12%	Explore
erythroblast	4 studies	44% ± 22%	Explore
hematopoietic stem cell	4 studies	32% ± 9%	Explore
pro-B cell	4 studies	36% ± 3%	Explore
immature B cell	4 studies	30% ± 18%	Explore
muscle cell	4 studies	32% ± 16%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	32% ± 5%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	34% ± 9%	Explore
T-helper 17 cell	4 studies	35% ± 21%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	24% ± 4%	Explore
deuterosomal cell	3 studies	46% ± 2%	Explore
duct epithelial cell	3 studies	24% ± 6%	Explore
ionocyte	3 studies	27% ± 3%	Explore
precursor cell	3 studies	47% ± 11%	Explore
pancreatic A cell	3 studies	45% ± 6%	Explore
type B pancreatic cell	3 studies	51% ± 16%	Explore
mononuclear phagocyte	3 studies	34% ± 17%	Explore
glomerular endothelial cell	3 studies	24% ± 2%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	40% ± 10%	Explore
renal alpha-intercalated cell	3 studies	37% ± 8%	Explore
neural crest cell	3 studies	48% ± 9%	Explore
common myeloid progenitor	3 studies	35% ± 13%	Explore
lymphocyte	3 studies	42% ± 13%	Explore
megakaryocyte	3 studies	17% ± 1%	Explore
alveolar macrophage	3 studies	19% ± 0%	Explore
intraepithelial lymphocyte	3 studies	34% ± 12%	Explore
Mueller cell	3 studies	26% ± 7%	Explore
germinal center B cell	3 studies	26% ± 8%	Explore
intermediate monocyte	3 studies	43% ± 17%	Explore
CD4-positive helper T cell	3 studies	28% ± 8%	Explore
myoepithelial cell	3 studies	36% ± 11%	Explore
neuron	3 studies	29% ± 11%	Explore
oligodendrocyte precursor cell	3 studies	25% ± 7%	Explore
granulocyte	3 studies	32% ± 10%	Explore
granulocyte monocyte progenitor cell	3 studies	51% ± 31%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	40% ± 20%	Explore
glial cell	3 studies	36% ± 20%	Explore
group 3 innate lymphoid cell	3 studies	42% ± 14%	Explore
keratinocyte	3 studies	19% ± 2%	Explore
T-helper 1 cell	3 studies	33% ± 5%	Explore
double negative thymocyte	3 studies	50% ± 29%	Explore
CD4-positive, alpha-beta cytotoxic T cell	3 studies	33% ± 4%	Explore
hepatocyte	3 studies	42% ± 24%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	16 studies	31% ± 12%	Explore
peripheral blood	16 studies	29% ± 8%	Explore
intestine	8 studies	32% ± 15%	Explore
kidney	7 studies	29% ± 6%	Explore
liver	7 studies	29% ± 21%	Explore
lymph node	6 studies	29% ± 10%	Explore
brain	5 studies	19% ± 3%	Explore
bone marrow	4 studies	25% ± 5%	Explore
uterus	4 studies	38% ± 13%	Explore
breast	4 studies	27% ± 6%	Explore
pancreas	3 studies	43% ± 15%	Explore
eye	3 studies	25% ± 5%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	2867.99	1445 / 1445	100%	31.14	183 / 183
ovary	100%	2885.72	180 / 180	100%	43.44	430 / 430
uterus	100%	2887.22	170 / 170	100%	66.14	459 / 459
thymus	100%	2963.36	653 / 653	100%	60.55	604 / 605
intestine	100%	2921.60	966 / 966	99%	46.92	524 / 527
prostate	100%	2898.20	245 / 245	99%	35.95	499 / 502
brain	99%	1379.49	2623 / 2642	100%	28.83	704 / 705
kidney	100%	2247.07	89 / 89	99%	26.03	890 / 901
adrenal gland	100%	2026.14	258 / 258	99%	33.90	227 / 230
stomach	100%	2421.41	359 / 359	99%	36.39	282 / 286
bladder	100%	2767.57	21 / 21	98%	51.28	496 / 504
lung	99%	2250.43	575 / 578	99%	42.84	1142 / 1155
pancreas	100%	1872.38	328 / 328	98%	33.78	175 / 178
liver	100%	2923.27	226 / 226	98%	32.23	399 / 406
skin	100%	2274.59	1809 / 1809	98%	32.50	463 / 472
breast	100%	2739.30	459 / 459	98%	32.98	1095 / 1118
eye	0%	0	0 / 0	100%	31.86	80 / 80
lymph node	0%	0	0 / 0	100%	58.64	29 / 29
muscle	100%	3129.97	803 / 803	0%	0	0 / 0
spleen	100%	2810.08	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	55.00	45 / 45
ureter	0%	0	0 / 0	100%	64.95	1 / 1
blood vessel	100%	4313.55	1334 / 1335	0%	0	0 / 0
adipose	100%	2592.97	1203 / 1204	0%	0	0 / 0
heart	99%	2062.74	852 / 861	0%	0	0 / 0
peripheral blood	86%	1305.15	801 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

IV. Literature review

[source]

Gene name	SIVA1
Protein name	Apoptosis regulatory protein Siva (CD27-binding protein) (CD27BP) SIVA1 apoptosis inducing factor Apoptosis regulatory protein Siva
Synonyms	SIVA
Description	FUNCTION: Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl-x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis. . FUNCTION: Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl-x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis. . FUNCTION: Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl-x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis. .
Accessions	B4DTY2 ENST00000347067.9 [O15304-2] ENST00000329967.11 [O15304-1] ENST00000535554.4 O15304 G3V439 G3V3U1 H0YJN1 ENST00000556195.2 ENST00000553810.5 ENST00000553819.5

GO_0097191	Biological process	extrinsic apoptotic signaling pathway
GO_0046718	Biological process	symbiont entry into host cell
GO_0005654	Cellular component	nucleoplasm
GO_0005737	Cellular component	cytoplasm
GO_0005164	Molecular function	tumor necrosis factor receptor binding
GO_0005175	Molecular function	CD27 receptor binding
GO_0005515	Molecular function	protein binding
GO_0001618	Molecular function	virus receptor activity
GO_0046872	Molecular function	metal ion binding

SIVA1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review