GSK3A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0097191Biological processextrinsic apoptotic signaling pathway
GO_1901524Biological processregulation of mitophagy
GO_1904227Biological processnegative regulation of glycogen synthase activity, transferring glucose-1-phosphate
GO_0010905Biological processnegative regulation of UDP-glucose catabolic process
GO_1901030Biological processpositive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
GO_0036016Biological processcellular response to interleukin-3
GO_0032869Biological processcellular response to insulin stimulus
GO_2000077Biological processnegative regulation of type B pancreatic cell development
GO_0071879Biological processpositive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway
GO_0141068Biological processautosome genomic imprinting
GO_0005977Biological processglycogen metabolic process
GO_0060079Biological processexcitatory postsynaptic potential
GO_0032436Biological processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO_0033138Biological processpositive regulation of peptidyl-serine phosphorylation
GO_0010628Biological processpositive regulation of gene expression
GO_0018107Biological processpeptidyl-threonine phosphorylation
GO_0032007Biological processnegative regulation of TOR signaling
GO_0003214Biological processcardiac left ventricle morphogenesis
GO_0046627Biological processnegative regulation of insulin receptor signaling pathway
GO_0090090Biological processnegative regulation of canonical Wnt signaling pathway
GO_2000466Biological processnegative regulation of glycogen (starch) synthase activity
GO_0061052Biological processnegative regulation of cell growth involved in cardiac muscle cell development
GO_0045732Biological processpositive regulation of protein catabolic process
GO_0003073Biological processregulation of systemic arterial blood pressure
GO_0008286Biological processinsulin receptor signaling pathway
GO_1902004Biological processpositive regulation of amyloid-beta formation
GO_0030154Biological processcell differentiation
GO_0010508Biological processpositive regulation of autophagy
GO_0097192Biological processextrinsic apoptotic signaling pathway in absence of ligand
GO_0019082Biological processviral protein processing
GO_2000467Biological processpositive regulation of glycogen (starch) synthase activity
GO_0010975Biological processregulation of neuron projection development
GO_0045823Biological processpositive regulation of heart contraction
GO_0031398Biological processpositive regulation of protein ubiquitination
GO_0071385Biological processcellular response to glucocorticoid stimulus
GO_0070507Biological processregulation of microtubule cytoskeleton organization
GO_1903955Biological processpositive regulation of protein targeting to mitochondrion
GO_0016055Biological processWnt signaling pathway
GO_0006468Biological processprotein phosphorylation
GO_0007399Biological processnervous system development
GO_0010800Biological processpositive regulation of peptidyl-threonine phosphorylation
GO_0045719Biological processnegative regulation of glycogen biosynthetic process
GO_0007212Biological processG protein-coupled dopamine receptor signaling pathway
GO_0106071Biological processpositive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO_0016477Biological processcell migration
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0046325Biological processnegative regulation of glucose import
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0071285Biological processcellular response to lithium ion
GO_0005739Cellular componentmitochondrion
GO_0098794Cellular componentpostsynapse
GO_0043025Cellular componentneuronal cell body
GO_0030877Cellular componentbeta-catenin destruction complex
GO_1990635Cellular componentproximal dendrite
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0097440Cellular componentapical dendrite
GO_0030424Cellular componentaxon
GO_0005634Cellular componentnucleus
GO_0106310Molecular functionprotein serine kinase activity
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0005102Molecular functionsignaling receptor binding
GO_0050321Molecular functiontau-protein kinase activity
GO_0034236Molecular functionprotein kinase A catalytic subunit binding
GO_0005524Molecular functionATP binding
GO_0048156Molecular functiontau protein binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameGSK3A
Protein name[tau protein] kinase (EC 2.7.11.26)
Glycogen synthase kinase 3 alpha
Glycogen synthase kinase-3 alpha (GSK-3 alpha) (EC 2.7.11.26) (Serine/threonine-protein kinase GSK3A) (EC 2.7.11.1)
Synonyms
DescriptionFUNCTION: Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), CTNNB1/beta-catenin, APC and AXIN1 . Requires primed phosphorylation of the majority of its substrates . Contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis . Regulates glycogen metabolism in liver, but not in muscle (By similarity). May also mediate the development of insulin resistance by regulating activation of transcription factors . In Wnt signaling, regulates the level and transcriptional activity of nuclear CTNNB1/beta-catenin . Facilitates amyloid precursor protein (APP) processing and the generation of APP-derived amyloid plaques found in Alzheimer disease . May be involved in the regulation of replication in pancreatic beta-cells (By similarity). Is necessary for the establishment of neuronal polarity and axon outgrowth (By similarity). Through phosphorylation of the anti-apoptotic protein MCL1, may control cell apoptosis in response to growth factors deprivation (By similarity). Acts as a regulator of autophagy by mediating phosphorylation of KAT5/TIP60 under starvation conditions which activates KAT5/TIP60 acetyltransferase activity and promotes acetylation of key autophagy regulators, such as ULK1 and RUBCNL/Pacer . Negatively regulates extrinsic apoptotic signaling pathway via death domain receptors. Promotes the formation of an anti-apoptotic complex, made of DDX3X, BRIC2 and GSK3B, at death receptors, including TNFRSF10B. The anti-apoptotic function is most effective with weak apoptotic signals and can be overcome by stronger stimulation (By similarity). Phosphorylates mTORC2 complex component RICTOR at 'Thr-1695' which facilitates FBXW7-mediated ubiquitination and subsequent degradation of RICTOR . .

AccessionsENST00000676537.1
ENST00000678324.1
A0A7I2YQ76
ENST00000678276.1
A8MT37
ENST00000398249.8
A0A7I2V2H8
A0A7I2V5B3
ENST00000222330.8
A0A7I2V2P9
ENST00000679145.1
ENST00000677575.1
ENST00000678427.1
ENST00000677469.1
A0A7I2V2Q4
A0A7I2V3W5
ENST00000677424.1
A0A7I2V2P0
A0A7I2V345
A0A7I2V4Z1
A0A7I2V5D7
ENST00000677751.1
ENST00000678936.1
ENST00000453535.1
A0A7I2YQJ1
ENST00000676724.1
ENST00000678672.1
A0A7I2YQU7
A0A7I2V341
A0A7I2V627
A0A7I2V485
A0A7I2YQV9
A0A7I2V5S8
A0A7I2V418
A0A7I2V2P8
ENST00000679257.1
ENST00000678751.1
A0A7I2V5P6
ENST00000676845.1
ENST00000677735.1
ENST00000678692.1
ENST00000677449.1
ENST00000676676.1
A0A7I2V2J2
A0A7I2V3H9
A0A7I2YQA1
A0A7I2YQA9
A0A7I2V4Q6
ENST00000678524.1
ENST00000678354.1
ENST00000678258.1
ENST00000679338.1
ENST00000677025.1
ENST00000678040.1
A0A7I2V4D4
P49840
A0A7I2V3M8
A0A7I2V442
A0A7I2V553
ENST00000676517.1
A0A7I2V511
ENST00000677371.1
ENST00000676790.1
ENST00000678008.1
ENST00000676603.1
ENST00000679279.1
ENST00000678491.1
A0A7I2V379
A0A7I2V5Q2
A0A7I2YQM8
A0A7I2V4Y3
ENST00000679108.1
ENST00000677702.1