TRADD report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0097191Biological processextrinsic apoptotic signaling pathway
GO_0007169Biological processcell surface receptor protein tyrosine kinase signaling pathway
GO_0007165Biological processsignal transduction
GO_0007249Biological processcanonical NF-kappaB signal transduction
GO_0008625Biological processextrinsic apoptotic signaling pathway via death domain receptors
GO_0051798Biological processpositive regulation of hair follicle development
GO_0051092Biological processpositive regulation of NF-kappaB transcription factor activity
GO_0071356Biological processcellular response to tumor necrosis factor
GO_0030335Biological processpositive regulation of cell migration
GO_0043123Biological processpositive regulation of canonical NF-kappaB signal transduction
GO_0006915Biological processapoptotic process
GO_0050729Biological processpositive regulation of inflammatory response
GO_0043065Biological processpositive regulation of apoptotic process
GO_0033209Biological processtumor necrosis factor-mediated signaling pathway
GO_0002947Cellular componenttumor necrosis factor receptor superfamily complex
GO_0005856Cellular componentcytoskeleton
GO_0043235Cellular componentreceptor complex
GO_0005886Cellular componentplasma membrane
GO_0009898Cellular componentcytoplasmic side of plasma membrane
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0031264Cellular componentdeath-inducing signaling complex
GO_0005634Cellular componentnucleus
GO_0070513Molecular functiondeath domain binding
GO_0060090Molecular functionmolecular adaptor activity
GO_0044877Molecular functionprotein-containing complex binding
GO_0019900Molecular functionkinase binding
GO_0042802Molecular functionidentical protein binding
GO_0005068Molecular functiontransmembrane receptor protein tyrosine kinase adaptor activity
GO_0005164Molecular functiontumor necrosis factor receptor binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTRADD
Protein nameTumor necrosis factor receptor type 1-associated DEATH domain protein (TNFR1-associated DEATH domain protein) (TNFRSF1A-associated via death domain)
Synonyms
DescriptionFUNCTION: Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD . Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B . The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A by TRIP12: acts by interacting with TRIP12, leading to disrupt interaction between TRIP12 and isoform p19ARF/ARF of CDKN2A (By similarity). .

AccessionsQ15628
ENST00000486556.1 [Q15628-2]
ENST00000345057.9 [Q15628-1]