Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| peripheral blood | 21 studies | 73% ± 18% | |
| lung | 14 studies | 36% ± 12% | |
| intestine | 5 studies | 31% ± 11% | |
| kidney | 5 studies | 37% ± 26% | |
| bone marrow | 5 studies | 44% ± 25% | |
| lymph node | 5 studies | 57% ± 23% | |
| liver | 4 studies | 44% ± 26% | |
| brain | 4 studies | 33% ± 11% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| lung | 100% | 11593.36 | 578 / 578 | 89% | 26.77 | 1030 / 1155 |
| breast | 72% | 1397.76 | 331 / 459 | 84% | 23.00 | 940 / 1118 |
| stomach | 64% | 1067.10 | 228 / 359 | 73% | 18.90 | 209 / 286 |
| intestine | 65% | 3086.58 | 629 / 966 | 67% | 13.40 | 352 / 527 |
| thymus | 65% | 1529.34 | 424 / 653 | 64% | 22.70 | 385 / 605 |
| bladder | 62% | 1363.29 | 13 / 21 | 55% | 10.68 | 276 / 504 |
| kidney | 36% | 915.70 | 32 / 89 | 78% | 22.69 | 700 / 901 |
| esophagus | 37% | 558.44 | 534 / 1445 | 72% | 13.75 | 132 / 183 |
| prostate | 51% | 888.06 | 125 / 245 | 52% | 7.29 | 260 / 502 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 169.50 | 29 / 29 |
| peripheral blood | 100% | 47965.66 | 929 / 929 | 0% | 0 | 0 / 0 |
| spleen | 100% | 25842.29 | 241 / 241 | 0% | 0 | 0 / 0 |
| uterus | 38% | 522.26 | 64 / 170 | 59% | 10.42 | 273 / 459 |
| adipose | 95% | 3159.10 | 1146 / 1204 | 0% | 0 | 0 / 0 |
| liver | 58% | 855.32 | 130 / 226 | 33% | 4.94 | 132 / 406 |
| brain | 24% | 436.53 | 623 / 2642 | 63% | 9.61 | 444 / 705 |
| pancreas | 10% | 134.93 | 32 / 328 | 76% | 20.07 | 135 / 178 |
| tonsil | 0% | 0 | 0 / 0 | 80% | 29.20 | 36 / 45 |
| skin | 19% | 235.70 | 343 / 1809 | 61% | 21.43 | 286 / 472 |
| adrenal gland | 50% | 625.48 | 129 / 258 | 16% | 1.41 | 37 / 230 |
| ovary | 14% | 193.58 | 25 / 180 | 50% | 5.62 | 217 / 430 |
| blood vessel | 55% | 1311.42 | 732 / 1335 | 0% | 0 | 0 / 0 |
| heart | 29% | 439.54 | 253 / 861 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 15% | 1.70 | 12 / 80 |
| muscle | 1% | 8.37 | 6 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0010468 | Biological process | regulation of gene expression |
| GO_0002639 | Biological process | positive regulation of immunoglobulin production |
| GO_0001779 | Biological process | natural killer cell differentiation |
| GO_0010332 | Biological process | response to gamma radiation |
| GO_0060369 | Biological process | positive regulation of Fc receptor mediated stimulatory signaling pathway |
| GO_0001915 | Biological process | negative regulation of T cell mediated cytotoxicity |
| GO_0001916 | Biological process | positive regulation of T cell mediated cytotoxicity |
| GO_0016311 | Biological process | dephosphorylation |
| GO_0050764 | Biological process | regulation of phagocytosis |
| GO_0031953 | Biological process | negative regulation of protein autophosphorylation |
| GO_0070374 | Biological process | positive regulation of ERK1 and ERK2 cascade |
| GO_0042110 | Biological process | T cell activation |
| GO_0030183 | Biological process | B cell differentiation |
| GO_0051726 | Biological process | regulation of cell cycle |
| GO_0007166 | Biological process | cell surface receptor signaling pathway |
| GO_0042102 | Biological process | positive regulation of T cell proliferation |
| GO_0002244 | Biological process | hematopoietic progenitor cell differentiation |
| GO_0006470 | Biological process | protein dephosphorylation |
| GO_0002925 | Biological process | positive regulation of humoral immune response mediated by circulating immunoglobulin |
| GO_0000165 | Biological process | MAPK cascade |
| GO_0045588 | Biological process | positive regulation of gamma-delta T cell differentiation |
| GO_0032677 | Biological process | regulation of interleukin-8 production |
| GO_0034113 | Biological process | heterotypic cell-cell adhesion |
| GO_0050852 | Biological process | T cell receptor signaling pathway |
| GO_0050857 | Biological process | positive regulation of antigen receptor-mediated signaling pathway |
| GO_0042492 | Biological process | gamma-delta T cell differentiation |
| GO_1904044 | Biological process | response to aldosterone |
| GO_0045060 | Biological process | negative thymic T cell selection |
| GO_0045059 | Biological process | positive thymic T cell selection |
| GO_0044770 | Biological process | cell cycle phase transition |
| GO_0001960 | Biological process | negative regulation of cytokine-mediated signaling pathway |
| GO_0046633 | Biological process | alpha-beta T cell proliferation |
| GO_0032760 | Biological process | positive regulation of tumor necrosis factor production |
| GO_0097191 | Biological process | extrinsic apoptotic signaling pathway |
| GO_2001238 | Biological process | positive regulation of extrinsic apoptotic signaling pathway |
| GO_0006469 | Biological process | negative regulation of protein kinase activity |
| GO_2000473 | Biological process | positive regulation of hematopoietic stem cell migration |
| GO_0032703 | Biological process | negative regulation of interleukin-2 production |
| GO_1904155 | Biological process | DN2 thymocyte differentiation |
| GO_0006933 | Biological process | negative regulation of cell adhesion involved in substrate-bound cell migration |
| GO_0050853 | Biological process | B cell receptor signaling pathway |
| GO_0070373 | Biological process | negative regulation of ERK1 and ERK2 cascade |
| GO_0061097 | Biological process | regulation of protein tyrosine kinase activity |
| GO_0032743 | Biological process | positive regulation of interleukin-2 production |
| GO_0030217 | Biological process | T cell differentiation |
| GO_0030890 | Biological process | positive regulation of B cell proliferation |
| GO_0042100 | Biological process | B cell proliferation |
| GO_0050856 | Biological process | regulation of T cell receptor signaling pathway |
| GO_0050766 | Biological process | positive regulation of phagocytosis |
| GO_0050850 | Biological process | positive regulation of calcium-mediated signaling |
| GO_0048539 | Biological process | bone marrow development |
| GO_0051607 | Biological process | defense response to virus |
| GO_2000648 | Biological process | positive regulation of stem cell proliferation |
| GO_1903979 | Biological process | negative regulation of microglial cell activation |
| GO_0048864 | Biological process | stem cell development |
| GO_0043410 | Biological process | positive regulation of MAPK cascade |
| GO_0051209 | Biological process | release of sequestered calcium ion into cytosol |
| GO_0045860 | Biological process | positive regulation of protein kinase activity |
| GO_0050732 | Biological process | negative regulation of peptidyl-tyrosine phosphorylation |
| GO_0050731 | Biological process | positive regulation of peptidyl-tyrosine phosphorylation |
| GO_0048304 | Biological process | positive regulation of isotype switching to IgG isotypes |
| GO_0046641 | Biological process | positive regulation of alpha-beta T cell proliferation |
| GO_0046425 | Biological process | regulation of receptor signaling pathway via JAK-STAT |
| GO_0007159 | Biological process | leukocyte cell-cell adhesion |
| GO_0045121 | Cellular component | membrane raft |
| GO_0009986 | Cellular component | cell surface |
| GO_0070062 | Cellular component | extracellular exosome |
| GO_0009897 | Cellular component | external side of plasma membrane |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0016020 | Cellular component | membrane |
| GO_0009898 | Cellular component | cytoplasmic side of plasma membrane |
| GO_0032059 | Cellular component | bleb |
| GO_0098857 | Cellular component | membrane microdomain |
| GO_0030667 | Cellular component | secretory granule membrane |
| GO_0005925 | Cellular component | focal adhesion |
| GO_0045202 | Cellular component | synapse |
| GO_0030507 | Molecular function | spectrin binding |
| GO_0005102 | Molecular function | signaling receptor binding |
| GO_0043395 | Molecular function | heparan sulfate proteoglycan binding |
| GO_0008201 | Molecular function | heparin binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0005001 | Molecular function | transmembrane receptor protein tyrosine phosphatase activity |
| GO_0019901 | Molecular function | protein kinase binding |
| GO_0030506 | Molecular function | ankyrin binding |
| GO_0004725 | Molecular function | protein tyrosine phosphatase activity |
| Gene name | PTPRC |
| Protein name | Receptor-type tyrosine-protein phosphatase C Protein tyrosine phosphatase receptor type C CD45 (Leukocyte common antigen) PTPRC protein Receptor-type tyrosine-protein phosphatase C (EC 3.1.3.48) (Leukocyte common antigen) (L-CA) (T200) (CD antigen CD45) CD45 Protein tyrosine phosphatase, receptor type, C (Receptor-type tyrosine-protein phosphatase C) protein-tyrosine-phosphatase (EC 3.1.3.48) CD45 transcript variant T200 leukocyte common antigen |
| Synonyms | CD45 hCG_1811178 |
| Description | FUNCTION: Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity). .; FUNCTION: (Microbial infection) Acts as a receptor for human cytomegalovirus protein UL11 and mediates binding of UL11 to T-cells, leading to reduced induction of tyrosine phosphorylation of multiple signaling proteins upon T-cell receptor stimulation and impaired T-cell proliferation. . |
| Accessions | A0A0G2JPD1 M9MML3 Q0VAE8 A0A140TA57 ENST00000697631.1 [P08575-8] A0A2R8Y5B1 Q6QIQ5 Q6LDN6 ENST00000570609.5 M9MMK8 ENST00000348564.11 [P08575-4] ENST00000571847.5 ENST00000573971.2 ENST00000367379.6 Q6QIR3 ENST00000697633.1 ENST00000418674.1 A0A075B788 ENST00000574718.2 A0A140TA79 ENST00000367367.8 ENST00000573477.5 Q6QIM3 ENST00000575923.5 ENST00000576833.5 A0A140TA59 ENST00000643513.1 ENST00000442510.8 [P08575-3] A0A140TA68 P08575 A0A2R8YE81 A0A0G2JNW2 A0A8V8TMR5 Q6QIN1 ENST00000367364.5 Q6QIN9 Q6Q1P2 ENST00000573298.5 ENST00000530727.5 M9MML4 M9MMK9 A0A140TA77 ENST00000529828.5 E9PKH0 Q9H3X6 ENST00000573679.5 Q6PJK7 ENST00000697632.1 M3ZCP1 ENST00000645247.1 A0A8V8TLH9 ENST00000413409.6 ENST00000574441.5 |
