PDPK1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0097191Biological processextrinsic apoptotic signaling pathway
GO_0018105Biological processpeptidyl-serine phosphorylation
GO_2000352Biological processnegative regulation of endothelial cell apoptotic process
GO_0006469Biological processnegative regulation of protein kinase activity
GO_0032148Biological processactivation of protein kinase B activity
GO_0032869Biological processcellular response to insulin stimulus
GO_0030512Biological processnegative regulation of transforming growth factor beta receptor signaling pathway
GO_0019722Biological processcalcium-mediated signaling
GO_0043536Biological processpositive regulation of blood vessel endothelial cell migration
GO_0045766Biological processpositive regulation of angiogenesis
GO_0071364Biological processcellular response to epidermal growth factor stimulus
GO_0048009Biological processinsulin-like growth factor receptor signaling pathway
GO_0031295Biological processT cell costimulation
GO_0043304Biological processregulation of mast cell degranulation
GO_0018107Biological processpeptidyl-threonine phosphorylation
GO_1905564Biological processpositive regulation of vascular endothelial cell proliferation
GO_1903672Biological processpositive regulation of sprouting angiogenesis
GO_0030036Biological processactin cytoskeleton organization
GO_0006972Biological processhyperosmotic response
GO_1903078Biological processpositive regulation of protein localization to plasma membrane
GO_0035556Biological processintracellular signal transduction
GO_0008286Biological processinsulin receptor signaling pathway
GO_0003323Biological processtype B pancreatic cell development
GO_0034122Biological processnegative regulation of toll-like receptor signaling pathway
GO_0007173Biological processepidermal growth factor receptor signaling pathway
GO_0051281Biological processpositive regulation of release of sequestered calcium ion into cytosol
GO_0051897Biological processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0010518Biological processpositive regulation of phospholipase activity
GO_0010667Biological processnegative regulation of cardiac muscle cell apoptotic process
GO_0006468Biological processprotein phosphorylation
GO_0043122Biological processregulation of canonical NF-kappaB signal transduction
GO_0046777Biological processprotein autophosphorylation
GO_0016477Biological processcell migration
GO_0005886Cellular componentplasma membrane
GO_0031410Cellular componentcytoplasmic vesicle
GO_0005925Cellular componentfocal adhesion
GO_0005829Cellular componentcytosol
GO_0014069Cellular componentpostsynaptic density
GO_0005737Cellular componentcytoplasm
GO_0042995Cellular componentcell projection
GO_0005634Cellular componentnucleus
GO_0016004Molecular functionphospholipase activator activity
GO_0106310Molecular functionprotein serine kinase activity
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0043274Molecular functionphospholipase binding
GO_0005524Molecular functionATP binding
GO_0004676Molecular function3-phosphoinositide-dependent protein kinase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePDPK1
Protein name3-phosphoinositide-dependent protein kinase 1 (hPDK1) (EC 2.7.11.1)
non-specific serine/threonine protein kinase (EC 2.7.11.1)
3-phosphoinositide dependent protein kinase 1
3-phosphoinositide-dependent protein kinase 1 (EC 2.7.11.1)
SynonymsPDK1
DescriptionFUNCTION: Serine/threonine kinase which acts as a master kinase, phosphorylating and activating a subgroup of the AGC family of protein kinases. Its targets include: protein kinase B (PKB/AKT1, PKB/AKT2, PKB/AKT3), p70 ribosomal protein S6 kinase (RPS6KB1), p90 ribosomal protein S6 kinase (RPS6KA1, RPS6KA2 and RPS6KA3), cyclic AMP-dependent protein kinase (PRKACA), protein kinase C (PRKCD and PRKCZ), serum and glucocorticoid-inducible kinase (SGK1, SGK2 and SGK3), p21-activated kinase-1 (PAK1), protein kinase PKN (PKN1 and PKN2). Plays a central role in the transduction of signals from insulin by providing the activating phosphorylation to PKB/AKT1, thus propagating the signal to downstream targets controlling cell proliferation and survival, as well as glucose and amino acid uptake and storage. Negatively regulates the TGF-beta-induced signaling by: modulating the association of SMAD3 and SMAD7 with TGF-beta receptor, phosphorylating SMAD2, SMAD3, SMAD4 and SMAD7, preventing the nuclear translocation of SMAD3 and SMAD4 and the translocation of SMAD7 from the nucleus to the cytoplasm in response to TGF-beta. Activates PPARG transcriptional activity and promotes adipocyte differentiation. Activates the NF-kappa-B pathway via phosphorylation of IKKB. The tyrosine phosphorylated form is crucial for the regulation of focal adhesions by angiotensin II. Controls proliferation, survival, and growth of developing pancreatic cells. Participates in the regulation of Ca(2+) entry and Ca(2+)-activated K(+) channels of mast cells. Essential for the motility of vascular endothelial cells (ECs) and is involved in the regulation of their chemotaxis. Plays a critical role in cardiac homeostasis by serving as a dual effector for cell survival and beta-adrenergic response. Plays an important role during thymocyte development by regulating the expression of key nutrient receptors on the surface of pre-T cells and mediating Notch-induced cell growth and proliferative responses. Provides negative feedback inhibition to toll-like receptor-mediated NF-kappa-B activation in macrophages. Isoform 3 is catalytically inactive. .

AccessionsH3BPR5
ENST00000441549.7 [O15530-5]
H3BNV5
ENST00000566659.1
H3BQA3
ENST00000492021.6
E9PER6
ENST00000474706.6
ENST00000478708.2
H3BPW1
ENST00000268673.11 [O15530-4]
ENST00000342085.9 [O15530-1]
ENST00000389224.7
H3BQ10
ENST00000461815.1
O15530