Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 42 studies | 67% ± 28% | |
fibroblast | 23 studies | 37% ± 16% | |
ciliated cell | 17 studies | 57% ± 19% | |
capillary endothelial cell | 17 studies | 78% ± 22% | |
endothelial cell of artery | 16 studies | 75% ± 20% | |
vein endothelial cell | 15 studies | 71% ± 26% | |
endothelial cell of vascular tree | 15 studies | 77% ± 28% | |
pericyte | 14 studies | 43% ± 27% | |
basal cell | 12 studies | 31% ± 19% | |
epithelial cell | 12 studies | 52% ± 21% | |
goblet cell | 11 studies | 59% ± 23% | |
macrophage | 10 studies | 31% ± 12% | |
type I pneumocyte | 8 studies | 51% ± 19% | |
secretory cell | 8 studies | 42% ± 20% | |
connective tissue cell | 8 studies | 40% ± 17% | |
enterocyte | 8 studies | 57% ± 31% | |
smooth muscle cell | 8 studies | 38% ± 14% | |
monocyte | 7 studies | 39% ± 14% | |
classical monocyte | 7 studies | 30% ± 11% | |
non-classical monocyte | 7 studies | 31% ± 14% | |
club cell | 6 studies | 45% ± 14% | |
platelet | 6 studies | 31% ± 12% | |
abnormal cell | 6 studies | 43% ± 21% | |
mesothelial cell | 6 studies | 40% ± 22% | |
ionocyte | 5 studies | 37% ± 11% | |
respiratory goblet cell | 5 studies | 61% ± 18% | |
plasmablast | 5 studies | 34% ± 7% | |
alveolar macrophage | 4 studies | 22% ± 1% | |
deuterosomal cell | 4 studies | 53% ± 10% | |
dendritic cell | 4 studies | 31% ± 3% | |
glomerular endothelial cell | 4 studies | 97% ± 1% | |
intestinal crypt stem cell | 4 studies | 47% ± 22% | |
transit amplifying cell | 4 studies | 51% ± 17% | |
myofibroblast cell | 4 studies | 29% ± 11% | |
adventitial cell | 4 studies | 21% ± 3% | |
mucus secreting cell | 4 studies | 37% ± 6% | |
myeloid cell | 4 studies | 30% ± 11% | |
brush cell | 4 studies | 35% ± 9% | |
plasma cell | 3 studies | 25% ± 3% | |
squamous epithelial cell | 3 studies | 58% ± 15% | |
plasmacytoid dendritic cell | 3 studies | 33% ± 10% | |
astrocyte | 3 studies | 26% ± 11% | |
progenitor cell | 3 studies | 74% ± 11% | |
type II pneumocyte | 3 studies | 27% ± 5% | |
erythrocyte | 3 studies | 34% ± 22% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
intestine | 98% | 4646.65 | 951 / 966 | 93% | 284.57 | 488 / 527 |
esophagus | 97% | 3527.81 | 1395 / 1445 | 87% | 241.68 | 160 / 183 |
stomach | 94% | 4010.74 | 336 / 359 | 89% | 210.76 | 255 / 286 |
uterus | 100% | 3169.15 | 170 / 170 | 81% | 421.18 | 374 / 459 |
lung | 100% | 10851.35 | 578 / 578 | 73% | 211.98 | 841 / 1155 |
breast | 100% | 7136.71 | 459 / 459 | 66% | 238.66 | 742 / 1118 |
kidney | 99% | 3646.58 | 88 / 89 | 67% | 118.77 | 602 / 901 |
bladder | 90% | 2103.81 | 19 / 21 | 71% | 278.37 | 356 / 504 |
ovary | 62% | 1195.87 | 111 / 180 | 88% | 460.80 | 380 / 430 |
adrenal gland | 100% | 5823.52 | 258 / 258 | 47% | 129.05 | 109 / 230 |
thymus | 98% | 2859.58 | 638 / 653 | 23% | 57.58 | 140 / 605 |
skin | 63% | 1456.57 | 1146 / 1809 | 53% | 185.13 | 251 / 472 |
brain | 87% | 1991.04 | 2307 / 2642 | 14% | 18.98 | 98 / 705 |
adipose | 100% | 7495.27 | 1204 / 1204 | 0% | 0 | 0 / 0 |
spleen | 100% | 14552.88 | 241 / 241 | 0% | 0 | 0 / 0 |
heart | 100% | 3558.28 | 858 / 861 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 96% | 456.49 | 43 / 45 |
pancreas | 7% | 80.28 | 23 / 328 | 84% | 308.00 | 150 / 178 |
prostate | 85% | 1502.19 | 209 / 245 | 3% | 7.13 | 17 / 502 |
muscle | 73% | 1011.37 | 588 / 803 | 0% | 0 | 0 / 0 |
liver | 29% | 1153.28 | 66 / 226 | 40% | 184.94 | 162 / 406 |
blood vessel | 61% | 1355.98 | 813 / 1335 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 45% | 52.47 | 13 / 29 |
peripheral blood | 24% | 1336.94 | 219 / 929 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 18% | 55.18 | 14 / 80 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0097191 | Biological process | extrinsic apoptotic signaling pathway |
GO_0097190 | Biological process | apoptotic signaling pathway |
GO_0045087 | Biological process | innate immune response |
GO_0051607 | Biological process | defense response to virus |
GO_0070269 | Biological process | pyroptotic inflammatory response |
GO_0000122 | Biological process | negative regulation of transcription by RNA polymerase II |
GO_0060337 | Biological process | type I interferon-mediated signaling pathway |
GO_0070936 | Biological process | protein K48-linked ubiquitination |
GO_0006915 | Biological process | apoptotic process |
GO_0046825 | Biological process | regulation of protein export from nucleus |
GO_0044827 | Biological process | modulation by host of viral genome replication |
GO_0043161 | Biological process | proteasome-mediated ubiquitin-dependent protein catabolic process |
GO_0005789 | Cellular component | endoplasmic reticulum membrane |
GO_0005739 | Cellular component | mitochondrion |
GO_0031966 | Cellular component | mitochondrial membrane |
GO_0005637 | Cellular component | nuclear inner membrane |
GO_0005635 | Cellular component | nuclear envelope |
GO_0005741 | Cellular component | mitochondrial outer membrane |
GO_0060090 | Molecular function | molecular adaptor activity |
GO_0042802 | Molecular function | identical protein binding |
GO_0061629 | Molecular function | RNA polymerase II-specific DNA-binding transcription factor binding |
GO_0005521 | Molecular function | lamin binding |
GO_0005515 | Molecular function | protein binding |
GO_0003674 | Molecular function | molecular_function |
Gene name | IFI27 |
Protein name | Interferon alpha-inducible protein 27, mitochondrial Interferon alpha-inducible protein 27 Interferon alpha inducible protein 27 (Interferon alpha-inducible protein 27, mitochondrial) Interferon alpha inducible protein 27 Interferon alpha-inducible protein 27, mitochondrial (p27) (Interferon alpha-induced 11.5 kDa protein) (Interferon-stimulated gene 12a protein) (ISG12(a)) (ISG12A) |
Synonyms | |
Description | FUNCTION: Probable adapter protein involved in different biological processes . Part of the signaling pathways that lead to apoptosis . Involved in type-I interferon-induced apoptosis characterized by a rapid and robust release of cytochrome C from the mitochondria and activation of BAX and caspases 2, 3, 6, 8 and 9 . Also functions in TNFSF10-induced apoptosis . May also have a function in the nucleus, where it may be involved in the interferon-induced negative regulation of the transcriptional activity of NR4A1, NR4A2 and NR4A3 through the enhancement of XPO1-mediated nuclear export of these nuclear receptors . May thereby play a role in the vascular response to injury (By similarity). In the innate immune response, has an antiviral activity towards hepatitis C virus/HCV . May prevent the replication of the virus by recruiting both the hepatitis C virus non-structural protein 5A/NS5A and the ubiquitination machinery via SKP2, promoting the ubiquitin-mediated proteasomal degradation of NS5A . Promotes also virus-induced pyroptosis by activating CASP3 in the mitochondria after 'Lys-6'-linked ubiquitination by TRIM21 . . |
Accessions | ENST00000618863.1 [P40305-3] A0A5H1ZRT4 ENST00000612813.4 [P40305-2] ENST00000621160.5 [P40305-2] ENST00000631302.2 ENST00000626715.2 ENST00000630123.2 ENST00000620396.4 A0A087X035 ENST00000614288.1 A0A348GSI0 ENST00000611954.4 P40305 A0A087X174 ENST00000618321.1 ENST00000615978.4 [P40305-3] ENST00000613997.4 [P40305-2] ENST00000630342.1 A0A087WV79 A0A087WUJ8 ENST00000627111.2 [P40305-2] ENST00000612838.4 [P40305-2] ENST00000616764.5 [P40305-2] ENST00000614204.4 A0A087WZR1 ENST00000618200.4 |