IFI27 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0097191Biological processextrinsic apoptotic signaling pathway
GO_0097190Biological processapoptotic signaling pathway
GO_0045087Biological processinnate immune response
GO_0051607Biological processdefense response to virus
GO_0070269Biological processpyroptotic inflammatory response
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0060337Biological processtype I interferon-mediated signaling pathway
GO_0070936Biological processprotein K48-linked ubiquitination
GO_0006915Biological processapoptotic process
GO_0046825Biological processregulation of protein export from nucleus
GO_0044827Biological processmodulation by host of viral genome replication
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005739Cellular componentmitochondrion
GO_0031966Cellular componentmitochondrial membrane
GO_0005637Cellular componentnuclear inner membrane
GO_0005635Cellular componentnuclear envelope
GO_0005741Cellular componentmitochondrial outer membrane
GO_0060090Molecular functionmolecular adaptor activity
GO_0042802Molecular functionidentical protein binding
GO_0061629Molecular functionRNA polymerase II-specific DNA-binding transcription factor binding
GO_0005521Molecular functionlamin binding
GO_0005515Molecular functionprotein binding
GO_0003674Molecular functionmolecular_function

IV. Literature review

[source]
Gene nameIFI27
Protein nameInterferon alpha-inducible protein 27, mitochondrial
Interferon alpha-inducible protein 27
Interferon alpha inducible protein 27 (Interferon alpha-inducible protein 27, mitochondrial)
Interferon alpha inducible protein 27
Interferon alpha-inducible protein 27, mitochondrial (p27) (Interferon alpha-induced 11.5 kDa protein) (Interferon-stimulated gene 12a protein) (ISG12(a)) (ISG12A)
Synonyms
DescriptionFUNCTION: Probable adapter protein involved in different biological processes . Part of the signaling pathways that lead to apoptosis . Involved in type-I interferon-induced apoptosis characterized by a rapid and robust release of cytochrome C from the mitochondria and activation of BAX and caspases 2, 3, 6, 8 and 9 . Also functions in TNFSF10-induced apoptosis . May also have a function in the nucleus, where it may be involved in the interferon-induced negative regulation of the transcriptional activity of NR4A1, NR4A2 and NR4A3 through the enhancement of XPO1-mediated nuclear export of these nuclear receptors . May thereby play a role in the vascular response to injury (By similarity). In the innate immune response, has an antiviral activity towards hepatitis C virus/HCV . May prevent the replication of the virus by recruiting both the hepatitis C virus non-structural protein 5A/NS5A and the ubiquitination machinery via SKP2, promoting the ubiquitin-mediated proteasomal degradation of NS5A . Promotes also virus-induced pyroptosis by activating CASP3 in the mitochondria after 'Lys-6'-linked ubiquitination by TRIM21 . .

AccessionsENST00000618863.1 [P40305-3]
A0A5H1ZRT4
ENST00000612813.4 [P40305-2]
ENST00000621160.5 [P40305-2]
ENST00000631302.2
ENST00000626715.2
ENST00000630123.2
ENST00000620396.4
A0A087X035
ENST00000614288.1
A0A348GSI0
ENST00000611954.4
P40305
A0A087X174
ENST00000618321.1
ENST00000615978.4 [P40305-3]
ENST00000613997.4 [P40305-2]
ENST00000630342.1
A0A087WV79
A0A087WUJ8
ENST00000627111.2 [P40305-2]
ENST00000612838.4 [P40305-2]
ENST00000616764.5 [P40305-2]
ENST00000614204.4
A0A087WZR1
ENST00000618200.4