Interactors | Protein name | Directionality | Classification | |
|---|---|---|---|---|
| 1 | IFNA1-IFNAR1+IFNAR2 | IFNA1 - | Ligand-Receptor | Signaling by Interferon |
| 2 | IFNA10-IFNAR1+IFNAR2 | IFN10_HUMAN - | Ligand-Receptor | Signaling by Interferon |
| 3 | IFNA14-IFNAR1+IFNAR2 | IFN14_HUMAN - | Ligand-Receptor | Signaling by Interferon |
| 4 | IFNA16-IFNAR1+IFNAR2 | IFN16_HUMAN - | Ligand-Receptor | Signaling by Interferon |
| 5 | IFNA17-IFNAR1+IFNAR2 | IFN17_HUMAN - | Ligand-Receptor | Signaling by Interferon |
| 6 | IFNA2-IFNAR1+IFNAR2 | IFNA2_HUMAN - | Ligand-Receptor | Signaling by Interferon |
| 7 | IFNA21-IFNAR1+IFNAR2 | IFN21_HUMAN - | Ligand-Receptor | Signaling by Interferon |
| 8 | IFNA4-IFNAR1+IFNAR2 | IFNA4_HUMAN - | Ligand-Receptor | Signaling by Interferon |
| 9 | IFNA5-IFNAR1+IFNAR2 | IFNA5_HUMAN - | Ligand-Receptor | Signaling by Interferon |
| 10 | IFNA6-IFNAR1+IFNAR2 | IFNA6_HUMAN - | Ligand-Receptor | Signaling by Interferon |
| 11 | IFNA7-IFNAR1+IFNAR2 | IFNA7_HUMAN - | Ligand-Receptor | Signaling by Interferon |
| 12 | IFNA8-IFNAR1+IFNAR2 | IFNA8_HUMAN - | Ligand-Receptor | Signaling by Interferon |
| 13 | IFNB1-IFNAR1+IFNAR2 | IFNB_HUMAN - | Ligand-Receptor | Signaling by Interferon |
| 14 | IFNE-IFNAR1+IFNAR2 | IFNE_HUMAN - | Ligand-Receptor | Signaling by Interferon |
| 15 | IFNK-IFNAR1+IFNAR2 | IFNK_HUMAN - | Ligand-Receptor | Signaling by Interferon |
| 16 | IFNW1-IFNAR1+IFNAR2 | IFNW1_HUMAN - | Ligand-Receptor | Signaling by Interferon |
| Name | type I interferon-mediated signaling pathway |
| ID | GO_0060337 |
| collection_id | Biological process |
| Exact synonym | type I interferon signaling pathway, type I interferon-activated signaling pathway |
| Description | The series of molecular signals initiated by type I interferon binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families. |
| External URL | |
| Genes | IFNAR2a5-ifnar_humanIFNA8SIN3Aa16-ifnar_humanTRIM65tbk1-ikke-tank_humana2-ifnar_humanIFNA21IFNA17JAK1STAT2IRF7OAS2IFNA2IFNA4tbk1-ikke-nap1_humana21-ifnar_humanTRAF3TBKBP1IFITM3HDAC4AZI2TBK1IFITM1IFITM2a6-ifnar_humana14-ifnar_humana1-ifnar_humanIFNW1a7-ifnar_humanTYK2IFI27MAVSa10-ifnar_humanIFNA6IFNKMYD88w1-ifnar_humanSTAT1IFNA14a8-ifnar_humanIFNB1IFNA16e-ifnar_humantbk1-ikke-sintbad_humanIFNAR1IFNA1IRF3TANKa4-ifnar_humana17-ifnar_humanIFIH1mavs-traf3_humanIFNA10IKBKEIRAK1IFNA5b1-ifnar_humanIFNESP100k-ifnar_humanIFNA7TREX1 |