SIN3A | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	10 studies	23% ± 8%	Explore
ciliated cell	5 studies	27% ± 8%	Explore
astrocyte	5 studies	25% ± 8%	Explore
B cell	4 studies	22% ± 4%	Explore
epithelial cell	4 studies	39% ± 10%	Explore
glutamatergic neuron	4 studies	35% ± 12%	Explore
macrophage	4 studies	20% ± 5%	Explore
microglial cell	3 studies	23% ± 2%	Explore
memory B cell	3 studies	17% ± 1%	Explore
lymphocyte	3 studies	23% ± 3%	Explore
basal cell	3 studies	28% ± 13%	Explore
GABAergic neuron	3 studies	33% ± 4%	Explore
pericyte	3 studies	18% ± 4%	Explore
transit amplifying cell	3 studies	31% ± 19%	Explore
neuron	3 studies	21% ± 4%	Explore
oligodendrocyte	3 studies	20% ± 4%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	5 studies	28% ± 8%	Explore
peripheral blood	3 studies	22% ± 2%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	4372.76	1445 / 1445	100%	26.02	183 / 183
ovary	100%	5528.84	180 / 180	100%	24.84	430 / 430
lung	100%	4238.07	578 / 578	100%	22.22	1154 / 1155
breast	100%	5125.20	459 / 459	100%	31.32	1117 / 1118
prostate	100%	4310.21	245 / 245	100%	20.76	501 / 502
thymus	100%	5423.20	653 / 653	100%	25.95	603 / 605
stomach	100%	3341.77	359 / 359	100%	17.60	285 / 286
intestine	100%	4745.35	966 / 966	100%	17.34	525 / 527
bladder	100%	5264.76	21 / 21	100%	16.69	502 / 504
uterus	100%	5774.01	170 / 170	100%	21.88	457 / 459
brain	99%	2372.34	2613 / 2642	100%	20.69	705 / 705
skin	100%	5264.36	1809 / 1809	98%	22.32	464 / 472
kidney	100%	2737.63	89 / 89	98%	15.89	880 / 901
pancreas	98%	1960.35	322 / 328	99%	17.10	176 / 178
adrenal gland	100%	3442.94	258 / 258	94%	13.34	216 / 230
liver	100%	1723.05	225 / 226	88%	9.17	356 / 406
adipose	100%	4678.70	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	20.43	29 / 29
muscle	100%	2475.88	803 / 803	0%	0	0 / 0
spleen	100%	4434.68	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	22.14	45 / 45
ureter	0%	0	0 / 0	100%	10.04	1 / 1
blood vessel	100%	4976.65	1334 / 1335	0%	0	0 / 0
heart	97%	2022.09	832 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	96%	15.42	77 / 80
peripheral blood	95%	2991.56	882 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0002244	Biological process	hematopoietic progenitor cell differentiation
GO_1903351	Biological process	cellular response to dopamine
GO_0071333	Biological process	cellular response to glucose stimulus
GO_0072736	Biological process	cellular response to tert-butyl hydroperoxide
GO_1902455	Biological process	negative regulation of stem cell population maintenance
GO_0010971	Biological process	positive regulation of G2/M transition of mitotic cell cycle
GO_0030516	Biological process	regulation of axon extension
GO_0030512	Biological process	negative regulation of transforming growth factor beta receptor signaling pathway
GO_0001701	Biological process	in utero embryonic development
GO_0000122	Biological process	negative regulation of transcription by RNA polymerase II
GO_0006260	Biological process	DNA replication
GO_0051595	Biological process	response to methylglyoxal
GO_0031507	Biological process	heterochromatin formation
GO_1902459	Biological process	positive regulation of stem cell population maintenance
GO_0060337	Biological process	type I interferon-mediated signaling pathway
GO_0010817	Biological process	regulation of hormone levels
GO_0042754	Biological process	negative regulation of circadian rhythm
GO_0043066	Biological process	negative regulation of apoptotic process
GO_0002218	Biological process	activation of innate immune response
GO_0030336	Biological process	negative regulation of cell migration
GO_1900181	Biological process	negative regulation of protein localization to nucleus
GO_0008104	Biological process	protein localization
GO_0045666	Biological process	positive regulation of neuron differentiation
GO_0021895	Biological process	cerebral cortex neuron differentiation
GO_0002230	Biological process	positive regulation of defense response to virus by host
GO_0048511	Biological process	rhythmic process
GO_0045892	Biological process	negative regulation of DNA-templated transcription
GO_0005730	Cellular component	nucleolus
GO_0000776	Cellular component	kinetochore
GO_0070822	Cellular component	Sin3-type complex
GO_0005654	Cellular component	nucleoplasm
GO_0017053	Cellular component	transcription repressor complex
GO_0000118	Cellular component	histone deacetylase complex
GO_0000785	Cellular component	chromatin
GO_0005634	Cellular component	nucleus
GO_0003677	Molecular function	DNA binding
GO_0003682	Molecular function	chromatin binding
GO_0140416	Molecular function	transcription regulator inhibitor activity
GO_0003714	Molecular function	transcription corepressor activity
GO_0061629	Molecular function	RNA polymerase II-specific DNA-binding transcription factor binding
GO_0003723	Molecular function	RNA binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	SIN3A
Protein name	SIN3 transcription regulator family member A Paired amphipathic helix protein Sin3a (Histone deacetylase complex subunit Sin3a) (Transcriptional corepressor Sin3a)
Synonyms
Description	FUNCTION: Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Involved in the control of the circadian rhythms. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation. Cooperates with FOXK1 to regulate cell cycle progression probably by repressing cell cycle inhibitor genes expression (By similarity). Required for cortical neuron differentiation and callosal axon elongation (By similarity). .
Accessions	ENST00000568431.5 ENST00000567289.5 A0A994J7C5 H3BQ88 A0A994J4B6 H3BMA2 A0A994J4B2 H3BT34 H3BQ76 ENST00000704312.1 ENST00000704302.1 ENST00000704311.1 ENST00000562776.5 ENST00000565264.2 ENST00000360439.8 H3BNZ3 ENST00000394949.8 H3BNA0 ENST00000394947.8 H3BP90 A0A994J7C7 ENST00000568309.5 Q96ST3 H3BQL7 ENST00000704310.1 ENST00000564778.6 ENST00000704304.1 ENST00000570115.5 ENST00000568190.1 ENST00000704305.1

SIN3A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review